Search Results - "Faje, Alexander"

Immunotherapy and hypophysitis: clinical presentation, treatment, and biologic insights by Faje, Alexander

“…Introduction Advances in immunotherapy have transformed the management of metastatic melanoma and generated encouraging results in the treatment of other…”
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High‐dose glucocorticoids for the treatment of ipilimumab‐induced hypophysitis is associated with reduced survival in patients with melanoma by Faje, Alexander T., Lawrence, Donald, Flaherty, Keith, Freedman, Christine, Fadden, Riley, Rubin, Krista, Cohen, Justine, Sullivan, Ryan J.

“…BACKGROUND It remains unclear whether high doses of glucocorticoids have a negative impact on the efficacy of checkpoint inhibitors. To control for the…”
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Ipilimumab-Induced Hypophysitis: A Detailed Longitudinal Analysis in a Large Cohort of Patients With Metastatic Melanoma by Faje, Alexander T, Sullivan, Ryan, Lawrence, Donald, Tritos, Nicholas A, Fadden, Riley, Klibanski, Anne, Nachtigall, Lisa

“…Context: Ipilimumab (Ipi) is approved by the Food and Drug Administration for the treatment of unresectable or metastatic melanoma. Little is known about…”
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Pituitary Complications of Checkpoint Inhibitor Use by Chamorro-Pareja, Natalia, Faje, Alexander T, Miller, Karen K

“…Abstract Immune checkpoint inhibitors have revolutionized cancer therapy but are associated with a risk of endocrine immune-related adverse events, including…”
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Chronic lymphocytic leukemia, a rare cause of pituitary stalk thickening by Faje, Alexander

“…This case highlights a rare presentation of chronic lymphocytic leukemia (CLL). CNS involvement by CLL is rare, and only 5 cases with pituitary or hypothalamic…”
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Hypophysitis secondary to nivolumab and pembrolizumab is a clinical entity distinct from ipilimumab-associated hypophysitis by Faje, Alexander, Reynolds, Kerry, Zubiri, Leyre, Lawrence, Donald, Cohen, Justine V, Sullivan, Ryan J, Nachtigall, Lisa, Tritos, Nicholas

“…Objective Little has been published describing hypophysitis after nivolumab or pembrolizumab treatment. We aimed to (i) assess the risk of hypophysitis…”
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Hyponatremia and other electrolyte abnormalities in patients receiving immune checkpoint inhibitors by Seethapathy, Harish, Rusibamayila, Nifasha, Chute, Donald F, Lee, Meghan, Strohbehn, Ian, Zubiri, Leyre, Faje, Alexander T, Reynolds, Kerry L, Jhaveri, Kenar D, Sise, Meghan E

“…Abstract Background Hyponatremia due to endocrinopathies such as adrenal insufficiency and hypothyroidism has been reported in patients receiving immune…”
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Fracture risk and areal bone mineral density in adolescent females with anorexia nervosa by Faje, Alexander T., Fazeli, Pouneh K., Miller, Karen K., Katzman, Debra K., Ebrahimi, Seda, Lee, Hang, Mendes, Nara, Snelgrove, Deirdre, Meenaghan, Erinne, Misra, Madhusmita, Klibanski, Anne

“…ABSTRACT Objective To (i) compare fracture prevalence in adolescent females with anorexia nervosa (AN) versus normal‐weight controls and (ii) examine whether…”
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Red and White Blood Cell Counts Are Associated With Bone Marrow Adipose Tissue, Bone Mineral Density, and Bone Microarchitecture in Premenopausal Women by Polineni, Sai, Resulaj, Megi, Faje, Alexander T, Meenaghan, Erinne, Bredella, Miriam A, Bouxsein, Mary, Lee, Hang, MacDougald, Ormond A, Klibanski, Anne, Fazeli, Pouneh K

“…ABSTRACT Bone marrow adipose tissue (BMAT) resides within the bone marrow microenvironment where its function remains poorly understood. BMAT is elevated in…”
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Reply to emergency management of immune‐related hypophysitis: Collaboration between specialists is essential to achieve optimal outcomes by Faje, Alexander T., Sullivan, Ryan J.

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Adolescent Girls With Anorexia Nervosa Have Impaired Cortical and Trabecular Microarchitecture and Lower Estimated Bone Strength at the Distal Radius by Faje, Alexander T, Karim, Lamya, Taylor, Alex, Lee, Hang, Miller, Karen K, Mendes, Nara, Meenaghan, Erinne, Goldstein, Mark A, Bouxsein, Mary L, Misra, Madhusmita, Klibanski, Anne

“…Context: Adolescents with anorexia nervosa (AN) have low areal bone mineral density (aBMD) at both cortical and trabecular sites, and recent data show impaired…”
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Low Plasma Oxytocin Levels and Increased Psychopathology in Hypopituitary Men With Diabetes Insipidus by Aulinas, Anna, Plessow, Franziska, Asanza, Elisa, Silva, Lisseth, Marengi, Dean A, Fan, WuQiang, Abedi, Parisa, Verbalis, Joseph, Tritos, Nicholas A, Nachtigall, Lisa, Faje, Alexander T, Miller, Karen K, Lawson, Elizabeth A

“…Abstract Context Oxytocin (OT) and vasopressin share anatomical pathways of synthesis and secretion, and patients with central diabetes insipidus (CDI)…”
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Treatment With a Ghrelin Agonist in Outpatient Women With Anorexia Nervosa: A Randomized Clinical Trial by Fazeli, Pouneh K, Lawson, Elizabeth A, Faje, Alexander T, Eddy, Kamryn T, Lee, Hang, Fiedorek, Fred T, Breggia, Anne, Gaal, Ildiko M, DeSanti, Rebecca, Klibanski, Anne

“…To assess the effects of relamorelin-an agonist of the appetite-stimulating hormone ghrelin, which has effects on gastric emptying-on (1) weight gain and (2)…”
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The treatment of hyperprolactinemia in postmenopausal women with prolactin-secreting microadenomas: Cons by Faje, Alexander T., Klibanski, Anne

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Accuracy of Late-Night Salivary Cortisol in Evaluating Postoperative Remission and Recurrence in Cushing's Disease by Amlashi, Fatemeh G, Swearingen, Brooke, Faje, Alexander T, Nachtigall, Lisa B, Miller, Karen K, Klibanski, Anne, Biller, Beverly M.K, Tritos, Nicholas A

“…Context: Late-night salivary cortisol (LNSC) is well-validated in the diagnosis of Cushing's disease (CD). The accuracy of LNSC during follow-up of patients…”
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Changes in marrow adipose tissue with short-term changes in weight in premenopausal women with anorexia nervosa by Fazeli, Pouneh K, Faje, Alexander T, Bredella, Miriam A, Polineni, Sai, Russell, Stephen, Resulaj, Megi, Rosen, Clifford J, Klibanski, Anne

“…Objective In anorexia nervosa, a psychiatric disease characterized by self-induced starvation and a model of chronic undernutrition, levels of subcutaneous…”
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Bone density, body composition, and psychopathology of anorexia nervosa spectrum disorders in DSM‐IV vs DSM‐5 by Schorr, Melanie, Thomas, Jennifer J., Eddy, Kamryn T., Dichtel, Laura E., Lawson, Elizabeth A., Meenaghan, Erinne, Lederfine Paskal, Margaret, Fazeli, Pouneh K., Faje, Alexander T., Misra, Madhusmita, Klibanski, Anne, Miller, Karen K.

“…ABSTRACT Objective DSM‐5 revised the diagnostic criteria for anorexia nervosa (AN) by eliminating the amenorrhea requirement, liberalizing weight and…”
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Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa by Fazeli, Pouneh K, Faje, Alexander T, Cross, Ela J, Lee, Hang, Rosen, Clifford J, Bouxsein, Mary L, Klibanski, Anne

“…Abstract Background Anorexia nervosa (AN) is a psychiatric disorder characterized by self-induced starvation and low body weight. Women with AN have impaired…”
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Temporal Trends and Outcomes Among Patients Admitted for Immune‐Related Adverse Events: A Single‐Center Retrospective Cohort Study from 2011 to 2018 by Molina, Gabriel E., Zubiri, Leyre, Cohen, Justine V., Durbin, Sienna M., Petrillo, Laura, Allen, Ian M., Murciano‐Goroff, Yonina R., Dougan, Michael, Thomas, Molly F., Faje, Alexander T., Rengarajan, Michelle, Guidon, Amanda C., Chen, Steven T., Okin, Daniel, Medoff, Benjamin D., Nasrallah, Mazen, Kohler, Minna J., Schoenfeld, Sara R., Karp Leaf, Rebecca S., Sise, Meghan E., Neilan, Tomas G., Zlotoff, Daniel A., Farmer, Jocelyn R., Mooradian, Meghan J., Bardia, Aditya, Mai, Minh, Sullivan, Ryan J., Semenov, Yevgeniy R., Villani, Alexandra Chloé, Reynolds, Kerry L.

“…Background The aim of this study was to characterize severe immune‐related adverse events (irAEs) seen among hospitalized patients and to examine risk factors…”
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Differences in Trabecular Plate and Rod Structure in Premenopausal Women Across the Weight Spectrum by Schorr, Melanie, Fazeli, Pouneh K, Bachmann, Katherine N, Faje, Alexander T, Meenaghan, Erinne, Kimball, Allison, Singhal, Vibha, Ebrahimi, Seda, Gleysteen, Suzanne, Mickley, Diane, Eddy, Kamryn T, Misra, Madhusmita, Klibanski, Anne, Miller, Karen K

“…Abstract Context Premenopausal women with anorexia nervosa (AN) and obesity (OB) have elevated fracture risk. More plate-like and axially aligned trabecular…”
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