Search Results - "Fajardo, J Eduardo"

A Designer Quest for the Achilles' Heel of Influenza by Fajardo, J Eduardo, Fiser, Andras

“…Monoclonal antibodies are attractive but, in certain applications, limited therapeutic modalities due to their large size and high specificity. In this issue…”
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Chi3l1 Is a Modulator of Glioma Stem Cell States and a Therapeutic Target in Glioblastoma by Guetta-Terrier, Charlotte, Karambizi, David, Akosman, Bedia, Zepecki, John P, Chen, Jia-Shu, Kamle, Suchitra, Fajardo, J Eduardo, Fiser, Andras, Singh, Ritambhara, Toms, Steven A, Lee, Chun Geun, Elias, Jack A, Tapinos, Nikos

“…Chitinase 3-like 1 (Chi3l1) is a secreted protein that is highly expressed in glioblastoma. Here, we show that Chi3l1 alters the state of glioma stem cells…”
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Genetic resistance to purine nucleoside phosphorylase inhibition in Plasmodium falciparum by Ducati, Rodrigo G., Namanja-Magliano, Hilda A., Harijan, Rajesh K., Fajardo, J. Eduardo, Fiser, Andras, Daily, Johanna P., Schramm, Vern L.

“…Plasmodium falciparum causes the most lethal form of human malaria and is a global health concern. The parasite responds to antimalarial therapies by…”
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Assessment of chemical‐crosslink‐assisted protein structure modeling in CASP13 by Fajardo, J. Eduardo, Shrestha, Rojan, Gil, Nelson, Belsom, Adam, Crivelli, Silvia N., Czaplewski, Cezary, Fidelis, Krzysztof, Grudinin, Sergei, Karasikov, Mikhail, Karczyńska, Agnieszka S., Kryshtafovych, Andriy, Leitner, Alexander, Liwo, Adam, Lubecka, Emilia A., Monastyrskyy, Bohdan, Pagès, Guillaume, Rappsilber, Juri, Sieradzan, Adam K., Sikorska, Celina, Trabjerg, Esben, Fiser, Andras

“…With the advance of experimental procedures obtaining chemical crosslinking information is becoming a fast and routine practice. Information on crosslinks can…”
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Comparative protein structure modeling by combining multiple templates and optimizing sequence-to-structure alignments by Fernandez-Fuentes, Narcis, Rai, Brajesh K., Madrid-Aliste, Carlos J., Eduardo Fajardo, J., Fiser, András

“…Motivation: Two major bottlenecks in advancing comparative protein structure modeling are the efficient combination of multiple template structures and the…”
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PSI-2: Structural Genomics to Cover Protein Domain Family Space by Dessailly, Benoît H., Nair, Rajesh, Jaroszewski, Lukasz, Fajardo, J. Eduardo, Kouranov, Andrei, Lee, David, Fiser, Andras, Godzik, Adam, Rost, Burkhard, Orengo, Christine

“…One major objective of structural genomics efforts, including the NIH-funded Protein Structure Initiative (PSI), has been to increase the structural coverage…”
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miRNA-mediated loss of m6A increases nascent translation in glioblastoma by Zepecki, John P, Karambizi, David, Fajardo, J Eduardo, Snyder, Kristin M, Guetta-Terrier, Charlotte, Tang, Oliver Y, Chen, Jia-Shu, Sarkar, Atom, Fiser, Andras, Toms, Steven A, Tapinos, Nikos

“…Within the glioblastoma cellular niche, glioma stem cells (GSCs) can give rise to differentiated glioma cells (DGCs) and, when necessary, DGCs can reciprocally…”
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Optimal selection of suitable templates in protein interface prediction by Grudman, Steven, Fajardo, J Eduardo, Fiser, Andras

“…Abstract Motivation Molecular-level classification of protein–protein interfaces can greatly assist in functional characterization and rational drug design…”
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INTERCAAT: identifying interface residues between macromolecules by Grudman, Steven, Fajardo, J Eduardo, Fiser, Andras

“…Abstract Summary The Interface Contact definition with Adaptable Atom Types (INTERCAAT) was developed to determine the atomic interactions between molecules…”
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Discovery of receptor‐ligand interfaces in the immunoglobulin superfamily by Gil, Nelson, Fajardo, Eduardo J., Fiser, Andras

“…Cell‐surface‐anchored immunoglobulin superfamily (IgSF) proteins are widespread throughout the human proteome, forming crucial components of diverse biological…”
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MMM: a sequence-to-structure alignment protocol by Rai, Brajesh K., Madrid-Aliste, Carlos J., Fajardo, J. Eduardo, Fiser, András

“…Motivation: Accurate alignment of a target sequence to a template structure continues to be a bottleneck in producing good quality comparative protein…”
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Protein structure based prediction of catalytic residues by Fajardo, J Eduardo, Fiser, Andras

“…Worldwide structural genomics projects continue to release new protein structures at an unprecedented pace, so far nearly 6000, but only about 60% of these…”
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Transactivation of Abl by the Crk II adapter protein requires a PNAY sequence in the Crk C-terminal SH3 domain by REICHMAN, Charles, SINGH, Kamalendra, YAN LIU, SINGH, Sukhwinder, HONG LI, FAJARDO, J. Eduardo, FISER, Andras, BIRGE, Raymond B

“…To gain a better understanding of how Crk II regulates the function of the Abl tyrosine kinase, we explored the function of the C-terminal linker and SH3…”
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Homology-based annotation yields 1,042 new candidate genes in the Drosophila melanogaster genome by Gaasterland, Terry, Gopal, Shuba, Schroeder, Mark, Pieper, Ursula, Sczyrba, Alexander, Aytekin-Kurban, Gulriz, Bekiranov, Stefan, Eduardo Fajardo, J, Eswar, Narayanan, Sanchez, Roberto, Sali, Andrej

“…The approach to annotating a genome critically affects the number and accuracy of genes identified in the genome sequence. Genome annotation based on stringent…”
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Crk at the Quarter Century Mark: Perspectives in Signaling and Cancer by Kumar, Sushil, Fajardo, J. Eduardo, Birge, Raymond B., Sriram, Ganapathy

“…ABSTRACT The Crk adaptor protein, discovered 25 years ago as the transforming gene (v‐crk) product encoded by the CT10 avian retrovirus, has made a great…”
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A Novel Role for the Immunophilin FKBP52 in Copper Transport by Sanokawa-Akakura, Reiko, Dai, Huachang, Akakura, Shin, Weinstein, David, Fajardo, J Eduardo, Lang, Steven E, Wadsworth, Scott, Siekierka, John, Birge, Raymond B

“…FK506-binding protein 52 (FKBP52) is an immunophilin that possesses peptidylprolyl cis/trans -isomerase (PPIase) activity and is a component of a subclass of…”
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Assessment of chemical‐crosslink‐assisted protein structure modeling in CASP13 by Fajardo, J. Eduardo, Shrestha, Rojan, Gil, Nelson, Belsom, Adam, Crivelli, Silvia N., Czaplewski, Cezary, Fidelis, Krzysztof, Grudinin, Sergei, Karasikov, Mikhail, Karczyńska, Agnieszka S., Kryshtafovych, Andriy, Leitner, Alexander, Liwo, Adam, Lubecka, Emilia A., Monastyrskyy, Bohdan, Pagès, Guillaume, Rappsilber, Juri, Sieradzan, Adam K., Sikorska, Celina, Trabjerg, Esben, Fiser, Andras

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Nuc-ErbB3 regulates H3K27me3 levels and HMT activity to establish epigenetic repression during peripheral myelination by Ness, Jennifer K., Skiles, Amanda A., Yap, Eng-Hui, Fajardo, Eduardo J., Fiser, Andras, Tapinos, Nikos

“…Nuc‐ErbB3 an alternative transcript from the ErbB3 locus binds to a specific DNA motif and associates with Schwann cell chromatin. Here we generated a…”
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M4T: a comparative protein structure modeling server by Fernandez-Fuentes, Narcis, Madrid-Aliste, Carlos J, Rai, Brajesh Kumar, Fajardo, J. Eduardo, Fiser, András

“…Multiple Mapping Method with Multiple Templates (M4T) (http://www.fiserlab.org/servers/m4t) is a fully automated comparative protein structure modeling server…”
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Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II by ZVARA, Agnes, FAJARDO, J. Eduardo, ESCALANTE, Marcela, COTTON, Graham, MUIR, Tom, KIRSCH, Kathrin H, BIRGE, Raymond B

“…The Crk II adaptor protein encodes an SH2/SH3-domain containing adaptor protein with an SH2-SH3-SH3 domain structure that transmits signals from tyrosine…”
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