Search Results - "Faisal, Saima"
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Spectrum and prevalence of BRCA1/2 germline mutations in Pakistani breast cancer patients: results from a large comprehensive study
Published in Hereditary cancer in clinical practice (11-09-2019)“…Pathogenic germline mutations in and ( ) account for the majority of hereditary breast and/or ovarian cancers worldwide. To refine the spectrum of mutations…”
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High prevalence and predominance of BRCA1 germline mutations in Pakistani triple-negative breast cancer patients
Published in BMC cancer (23-08-2016)“…Women harboring BRCA1/2 germline mutations have high lifetime risk of developing breast/ovarian cancer. The recommendation to pursue BRCA1/2 testing is based…”
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The Impact of Culture and Sociological and Psychological Issues on Muslim Patients With Breast Cancer in Pakistan
Published in Cancer nursing (01-07-2009)“…Breast cancer is the most common form of cancer in Muslim women in Pakistan. The impact of the initial diagnosis, culture, religion, and psychosocial and…”
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Constitutional CHEK2 mutations are infrequent in early-onset and familial breast/ovarian cancer patients from Pakistan
Published in BMC cancer (27-06-2013)“…Less than 20% of Pakistani women with early-onset or familial breast/ovarian cancer harbor germ line mutations in the high-penetrance genes BRCA1, BRCA2 and…”
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5
Patterns of cancer cell sphere formation in primary cultures of human oral tongue squamous cell carcinoma and neck nodes
Published in Cancer cell international (21-12-2014)“…Recently a sub-population of cells with stem cell characteristics, reported to be associated with initiation, growth, spread and recurrence, has been…”
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Deleterious RAD51C germline mutations rarely predispose to breast and ovarian cancer in Pakistan
Published in Breast cancer research and treatment (01-06-2014)“…RAD51C plays a key role in homologous recombination-mediated DNA repair and maintenance of genomic stability. Biallelic RAD51C mutations cause Fanconi anemia,…”
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Constitutional CHEK2mutations are infrequent in early-onset and familial breast/ovarian cancer patients from Pakistan
Published in BMC cancer (27-06-2013)“…Background Less than 20% of Pakistani women with early-onset or familial breast/ovarian cancer harbor germ line mutations in the high-penetrance genes BRCA1,…”
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Identification of the deleterious 2080insA BRCA1 mutation in a male renal cell carcinoma patient from a family with multiple cancer diagnoses from Pakistan
Published in Familial cancer (01-12-2011)“…Pathogenic germ line mutations in the BRCA1 and BRCA2 genes confer elevated risk of breast and ovarian cancer in females and have a link with variety of…”
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