Search Results - "Fais, Stefano"

Scientific Discoveries Supporting Theories in Science: From Thinking to Practice by Fais, Stefano

“…The idea to propose this ambitious title for a Special Issue in the came, on one hand, from my personal experience in research in medicine, lasting 41 years,…”
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NK cell-released exosomes: Natural nanobullets against tumors by Fais, Stefano

“…We have recently reported that human natural killer (NK) cells release exosomes that express both NK-cell markers and cytotoxic molecules. Similar results were…”
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The Diagnostic and Prognostic Value of Plasmatic Exosome Count in Cancer Patients and in Patients with Other Pathologies by Fais, Stefano, Logozzi, Mariantonia

“…The extent of both scientific articles and reviews on extracellular vesicles (EVs) has grown impressively over the last few decades [...]…”
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Drug repurposing for anticancer therapies. A lesson from proton pump inhibitors by Spugnini, Enrico Pierluigi, Fais, Stefano

“…: Worldwide, the annual expenditure on anticancer drugs is grossly calculated to be in the order of US$100 billion, and is expected to escalate up to $150…”
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Exosomes: the future of biomarkers in medicine by Properzi, Francesca, Logozzi, Mariantonia, Fais, Stefano

“…Exosomes are nanovesicles secreted into the extracellular environment upon internal vesicle fusion with the plasma membrane. The molecular content of exosomes…”
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Extracellular acidity and increased exosome release as key phenotypes of malignant tumors by Logozzi, Mariantonia, Spugnini, Enrico, Mizzoni, Davide, Di Raimo, Rossella, Fais, Stefano

“…The tumor milieu is characteristically acidic as a consequence of the fermentative metabolism of glucose that results in massive accumulation of lactic acid…”
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The Potentiality of Plant-Derived Nanovesicles in Human Health-A Comparison with Human Exosomes and Artificial Nanoparticles by Logozzi, Mariantonia, Di Raimo, Rossella, Mizzoni, Davide, Fais, Stefano

“…Research in science and medicine is witnessing a massive increases in literature concerning extracellular vesicles (EVs). From a morphological point of view,…”
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Nanovesicles from Organic Agriculture-Derived Fruits and Vegetables: Characterization and Functional Antioxidant Content by Logozzi, Mariantonia, Di Raimo, Rossella, Mizzoni, Davide, Fais, Stefano

“…Dietary consumption of fruits and vegetables is related to a risk reduction in a series of leading human diseases, probably due to the plants’ antioxidant…”
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The key role of extracellular vesicles in the metastatic process by Zhao, Hongyun, Achreja, Abhinav, Iessi, Elisabetta, Logozzi, Mariantonia, Mizzoni, Davide, Di Raimo, Rossella, Nagrath, Deepak, Fais, Stefano

“…Extracellular vesicles (EVs), including exosomes, have a key role in the paracrine communication between organs and compartments. EVs shuttle virtually all…”
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Increased PSA expression on prostate cancer exosomes in in vitro condition and in cancer patients by Logozzi, Mariantonia, Angelini, Daniela F., Iessi, Elisabetta, Mizzoni, Davide, Di Raimo, Rossella, Federici, Cristina, Lugini, Luana, Borsellino, Giovanna, Gentilucci, Alessandro, Pierella, Federico, Marzio, Vittorio, Sciarra, Alessandro, Battistini, Luca, Fais, Stefano

“…Prostate specific antigen (PSA) test is the most common, clinically validated test for the diagnosis of prostate cancer (PCa). While neoplastic lesions of the…”
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Microenvironment acidity as a major determinant of tumor chemoresistance: Proton pump inhibitors (PPIs) as a novel therapeutic approach by Taylor, Sophie, Spugnini, Enrico Pierluigi, Assaraf, Yehuda G, Azzarito, Tommaso, Rauch, Cyril, Fais, Stefano

“…Abstract Despite the major progresses in biomedical research and the development of novel therapeutics and treatment strategies, cancer is still among the…”
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Microenvironmental pH and Exosome Levels Interplay in Human Cancer Cell Lines of Different Histotypes by Logozzi, Mariantonia, Mizzoni, Davide, Angelini, Daniela F, Di Raimo, Rossella, Falchi, Mario, Battistini, Luca, Fais, Stefano

“…Exosomes are extracellular nanovesicles primarily involved in the pathogenesis of many diseases including cancer. This study was set out from recent evidence…”
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Unexpected Discoveries Should Be Reconsidered in Science-A Look to the Past? by Foletti, Alberto, Fais, Stefano

“…From the past, we know how much "serendipity" has played a pivotal role in scientific discoveries. The definition of serendipity implies the finding of one…”
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Soma-to-germline transmission of RNA in mice xenografted with human tumour cells: possible transport by exosomes by Cossetti, Cristina, Lugini, Luana, Astrologo, Letizia, Saggio, Isabella, Fais, Stefano, Spadafora, Corrado

“…Mendelian laws provide the universal founding paradigm for the mechanism of genetic inheritance through which characters are segregated and assorted. In recent…”
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Exosome release and low pH belong to a framework of resistance of human melanoma cells to cisplatin by Federici, Cristina, Petrucci, Francesco, Caimi, Stefano, Cesolini, Albino, Logozzi, Mariantonia, Borghi, Martina, D'Ilio, Sonia, Lugini, Luana, Violante, Nicola, Azzarito, Tommaso, Majorani, Costanza, Brambilla, Daria, Fais, Stefano

“…Intrinsic resistance to cytotoxic drugs has been a main issue in cancer therapy for decades. Microenvironmental acidity is a simple while highly efficient…”
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Proposal to Consider Chemical/Physical Microenvironment as a New Therapeutic Off-Target Approach by Giuliani, Alessandro, Fais, Stefano

“…The molecular revolution could lead drug discovery from chance observation to the rational design of new classes of drugs that could simultaneously be more…”
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On the Choice of the Extracellular Vesicles for Therapeutic Purposes by Campanella, Claudia, Caruso Bavisotto, Celeste, Logozzi, Mariantonia, Marino Gammazza, Antonella, Mizzoni, Davide, Cappello, Francesco, Fais, Stefano

“…Extracellular vesicles (EVs) are lipid membrane vesicles released by all human cells and are widely recognized to be involved in many cellular processes, both…”
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Immune surveillance properties of human NK cell-derived exosomes by Lugini, Luana, Cecchetti, Serena, Huber, Veronica, Luciani, Francesca, Macchia, Gianfranco, Spadaro, Francesca, Paris, Luisa, Abalsamo, Laura, Colone, Marisa, Molinari, Agnese, Podo, Franca, Rivoltini, Licia, Ramoni, Carlo, Fais, Stefano

“…Exosomes are nanovesicles released by normal and tumor cells, which are detectable in cell culture supernatant and human biological fluids, such as plasma…”
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Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells by Parolini, Isabella, Federici, Cristina, Raggi, Carla, Lugini, Luana, Palleschi, Simonetta, De Milito, Angelo, Coscia, Carolina, Iessi, Elisabetta, Logozzi, Mariantonia, Molinari, Agnese, Colone, Marisa, Tatti, Massimo, Sargiacomo, Massimo, Fais, Stefano

“…Exosomes secreted by normal and cancer cells carry and deliver a variety of molecules. To date, mechanisms referring to tumor exosome trafficking, including…”
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A Role of Tumor-Released Exosomes in Paracrine Dissemination and Metastasis by Spugnini, Enrico Pierluigi, Logozzi, Mariantonia, Di Raimo, Rossella, Mizzoni, Davide, Fais, Stefano

“…Metastatic diffusion is thought to be a multi-step phenomenon involving the release of cells from the primary tumor and their diffusion through the body…”
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