Search Results - "Fairlamb, A.H"

A 7.1 kb linear DNA molecule of Theileria parva has scrambled rDNA sequences and open reading frames for mitochondrially encoded proteins by Kairo, A., Fairlamb, A.H., Gobright, E., Nene, V.

“…Theileria parva, an intralymphocytic protozoan parasite of cattle, contains a linear 7.1 kb DNA element with terminal inverted repeat sequences. The molecule…”
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Increased levels of thiols protect antimony unresponsive Leishmania donovani field isolates against reactive oxygen species generated by trivalent antimony by Mandal, G, Wyllie, S, Singh, N, Sundar, S, Fairlamb, A H, Chatterjee, M

“…The current trend of antimony (Sb) unresponsiveness in the Indian subcontinent is a major impediment to effective chemotherapy of visceral leishmaniasis (VL)…”
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Fexinidazole for the treatment of human African trypanosomiasis by Fairlamb, A H

“…On November 15, 2018, Fexinidazole Winthrop received a positive opinion from the European Medicines Agency (EMA) (under Article 58) for treatment of…”
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SURFACE RECEPTORS AND TRANSPORTERS OF TRYPANOSOMA BRUCEI by Borst, P, Fairlamb, A. H

“…African trypanosomes combine antigenic variation of their surface coat with the ability to take up nutrients from their mammalian hosts. Uptake of small…”
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Cloning, expression and reconstitution of the trypanothione-dependent peroxidase system of Crithidia fasciculata by Tetaud, Emmanuel, Fairlamb, Alan H.

“…As a consequence of aerobic metabolism, trypanosomatids are exposed to reactive oxygen intermediates such as superoxide, hydrogen peroxide and the hydroxyl…”
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Characterization of kinetoplast DNA networks from the insect trypanosome Crithidia luciliae by Weislogel, P O, Hoeijmakers, J H, Fairlamb, A H, Kleisen, C M, Borst, P

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Purification of glutathionylspermidine and trypanothione synthetases from crithidia fasciculata by Smith, K., Fairlamb, A.H., Nadeau, K., Bradley, M., Walsh, C.

“…Two enzymes involved in the biosynthesis of the trypanosomatid‐specific dithiol trypanothione‐glutathionylspermidine (Gsp) synthetase and trypanothione (TSH)…”
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Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases by Shames, S.L, Fairlamb, A.H, Cerami, A, Walsh, C.T

“…Trypanothione reductase from Crithidia fasciculata has been purified ca. 1400-fold to homogeneity in an overall yield of 60%. The pure enzyme showed a pH…”
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Characterisation of pentamidine-resistant Trypanosoma brucei brucei by Berger, Bradley J., Carter, Nicola S., Fairlamb, Alan H.

“…Following selection in vitro by exposure to increasing concentrations of the aromatic diamidine pentamidine, a Trypanosoma brucei brucei clone has been…”
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Synthesis and enzymology of modified N-benzyloxycarbonyl-L-cysteinylglycyl-3,3-dimethylaminopropylamide disulphides as alternative substrates for trypanothione reductase from Trypanosoma cruzi. 3 by Yuen, C.T, Garforth, J, Besheya, T, Jaouhari, R, McKie, J.H, Fairlamb, A.H, Douglas, K.T

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Novel biochemical pathways in parasitic protozoa by Fairlamb, A H

“…Throughout evolution, enzymes and their metabolites have been highly conserved. Parasites are no exception to this and differ most markedly by the absence of…”
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Diamine auxotrophy in a eukaryotic parasite by Ariyanayagam, M R, Tetaud, E, Fairlamb, A H

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Levels of polyamines, glutathione and glutathione-spermidine conjugates during growth of the insect trypanosomatid Crithidia fasciculata by Shim, H, Fairlamb, A.H

“…Laboratory of Medical Biochemistry, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA ABSTRACT SUMMARY: Levels of the polyamines spermidine…”
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Specificity of Ethanolamine Transport and Its Further Metabolism in Trypanosoma brucei by Rifkin, Mary R., Strobos, Carolyn A.M., Fairlamb, Alan H.

“…Ethanolamine is found in trypanosomes as an integral component of the variant surface glycoprotein (VSG) and the membrane phospholipid phosphatidylethanolamine…”
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In vivo effects of difluoromethylornithine on trypanothione and polyamine levels in bloodstream forms of Trypanosoma brucei by Fairlamb, A H, Henderson, G B, Bacchi, C J, Cerami, A

“…The effect of D,L-alpha-difluoromethylornithine (DFMO) on thiol and polyamine levels in Trypanosoma brucei was investigated by isolating trypanosomes from…”
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Identification of a novel, thiol-containing co-factor essential for glutathione reductase enzyme activity in trypanosomatids by Fairlamb, A H, Cerami, A

“…Soluble extracts of Trypanosoma brucei, T. cruzi, Leishmania mexicana and Crithidia fasciculata contain a novel enzyme capable of reducing oxidized glutathione…”
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Characterization of the peptide substrate specificity of glutathionylspermidine synthetase from Crithidia fasciculata by Craecker, S. de, Verbruggen, C, Rajan, P.K, Smith, K, Haemers, A, Fairlamb, A.H

“…Trypanothione, a metabolite specific to trypanosomatid parasites, is enzymatically synthesized from spermidine and glutathione by the consecutive action of the…”
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Trypanothione dependent peroxide metabolism in Crithidia fasciculata and Trypanosoma brucei by Henderson, G B, Fairlamb, A H, Cerami, A

“…A trypanothione-dependent peroxidase activity has been identified in the insect trypanosomatid Crithidia fasciculata and in the mammalian trypanosome…”
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The Biochemical Basis of Arsenical–Diamidine Crossresistance in African Trypanosomes by Barrett, M.P., Fairlamb, A.H.

“…Resistance to currently used drugs is a serious problem in most fields of antimicrobial chemotherapy. Crossresistance between two of the major classes of drug…”
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Biochemical changes associated with alpha-difluoromethylornithine uptake and resistance in Trypanosoma brucei by Bellofatto, V, Fairlamb, A H, Henderson, G B, Cross, G A

“…Procyclic Trypanosoma brucei grown in semi-defined media are sensitive to alpha-difluoromethylornithine (DFMO) (EC50 100 microM), an inhibitor of ornithine…”
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