Search Results - "Fairhurst, Rick M."

Haemoglobinopathies and the clinical epidemiology of malaria: a systematic review and meta-analysis by Taylor, Steve M, Dr, Parobek, Christian M, BS, Fairhurst, Rick M, MD

“…Summary Background Haemoglobinopathies can reduce the risk of malaria syndromes. We aimed to quantify the relation between different haemoglobin mutations and…”
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Origins of the current outbreak of multidrug-resistant malaria in southeast Asia: a retrospective genetic study by Amato, Roberto, Pearson, Richard D, Almagro-Garcia, Jacob, Amaratunga, Chanaki, Lim, Pharath, Suon, Seila, Sreng, Sokunthea, Drury, Eleanor, Stalker, Jim, Miotto, Olivo, Fairhurst, Rick M, Kwiatkowski, Dominic P

“…Antimalarial resistance is rapidly spreading across parts of southeast Asia where dihydroartemisinin–piperaquine is used as first-line treatment for Plasmodium…”
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Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study by Amaratunga, Chanaki, PhD, Lim, Pharath, PhD, Suon, Seila, MD, Sreng, Sokunthea, Mao, Sivanna, MD, Sopha, Chantha, MD, Sam, Baramey, MD, Dek, Dalin, BA, Try, Vorleak, BA, Amato, Roberto, PhD, Blessborn, Daniel, PhD, Song, Lijiang, PhD, Tullo, Gregory S, BS, Fay, Michael P, PhD, Anderson, Jennifer M, PhD, Tarning, Joel, PhD, Fairhurst, Rick M, Dr

“…Summary Background Artemisinin resistance in Plasmodium falciparum threatens to reduce the efficacy of artemisinin combination therapies (ACTs), thus…”
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Genetic markers associated with dihydroartemisinin–piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype–phenotype association study by Amato, Roberto, Dr, Lim, Pharath, MD, Miotto, Olivo, PhD, Amaratunga, Chanaki, PhD, Dek, Dalin, MSc, Pearson, Richard D, PhD, Almagro-Garcia, Jacob, MSc, Neal, Aaron T, PhD, Sreng, Sokunthea, Suon, Seila, MD, Drury, Eleanor, BSc[Hons], Jyothi, Dushyanth, MPhil, Stalker, Jim, MA, Kwiatkowski, Dominic P, FRCP, Fairhurst, Rick M, Dr

“…Summary Background As the prevalence of artemisinin-resistant Plasmodium falciparum malaria increases in the Greater Mekong subregion, emerging resistance to…”
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Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies by Witkowski, Benoit, PhD, Amaratunga, Chanaki, PhD, Khim, Nimol, MSc, Sreng, Sokunthea, Chim, Pheaktra, Kim, Saorin, Lim, Pharath, MD, Mao, Sivanna, MD, Sopha, Chantha, MD, Sam, Baramey, MD, Anderson, Jennifer M, PhD, Duong, Socheat, Prof, Chuor, Char Meng, MD, Taylor, Walter R J, MD, Suon, Seila, MD, Mercereau-Puijalon, Odile, PhD, Fairhurst, Rick M, Dr, Menard, Didier, Dr

“…Summary Background Artemisinin resistance in Plasmodium falciparum lengthens parasite clearance half-life during artemisinin monotherapy or artemisinin-based…”
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Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine by Ross, Leila S., Dhingra, Satish K., Mok, Sachel, Yeo, Tomas, Wicht, Kathryn J., Kümpornsin, Krittikorn, Takala-Harrison, Shannon, Witkowski, Benoit, Fairhurst, Rick M., Ariey, Frederic, Menard, Didier, Fidock, David A.

“…The widely used antimalarial combination therapy dihydroartemisinin + piperaquine (DHA + PPQ) has failed in Cambodia. Here, we perform a genomic analysis that…”
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Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival by Mok, Sachel, Stokes, Barbara H., Gnädig, Nina F., Ross, Leila S., Yeo, Tomas, Amaratunga, Chanaki, Allman, Erik, Solyakov, Lev, Bottrill, Andrew R., Tripathi, Jaishree, Fairhurst, Rick M., Llinás, Manuel, Bozdech, Zbynek, Tobin, Andrew B., Fidock, David A.

“…The emergence and spread of artemisinin resistance, driven by mutations in Plasmodium falciparum K13, has compromised antimalarial efficacy and threatens the…”
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Hemoglobinopathies: slicing the Gordian knot of Plasmodium falciparum malaria pathogenesis by Taylor, Steve M, Cerami, Carla, Fairhurst, Rick M

“…Plasmodium falciparum malaria kills over 500,000 children every year and has been a scourge of humans for millennia. Owing to the co-evolution of humans and P…”
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Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum by Bopp, Selina, Magistrado, Pamela, Wong, Wesley, Schaffner, Stephen F., Mukherjee, Angana, Lim, Pharath, Dhorda, Mehul, Amaratunga, Chanaki, Woodrow, Charles J., Ashley, Elizabeth A., White, Nicholas J., Dondorp, Arjen M., Fairhurst, Rick M., Ariey, Frederic, Menard, Didier, Wirth, Dyann F., Volkman, Sarah K.

“…Multidrug resistant Plasmodium falciparum in Southeast Asia endangers regional malaria elimination and threatens to spread to other malaria endemic areas…”
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The Threat of Artemisinin-Resistant Malaria by Dondorp, Arjen M, Fairhurst, Rick M, Slutsker, Laurence, MacArthur, John R, M.D, Joel G. Breman, Guerin, Philippe J, Wellems, Thomas E, Ringwald, Pascal, Newman, Robert D, Plowe, Christopher V

“…Since the 1970s, when Chinese researchers demonstrated the artemisinins' antimalarial potency, artemisinin-based combination therapy has become key to malaria…”
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Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study by Amaratunga, Chanaki, PhD, Sreng, Sokunthea, Suon, Seila, MD, Phelps, Erika S, BA, Stepniewska, Kasia, PhD, Lim, Pharath, MD, Zhou, Chongjun, MD, Mao, Sivanna, MD, Anderson, Jennifer M, PhD, Lindegardh, Niklas, PhD, Jiang, Hongying, PhD, Song, Jianping, Prof, Su, Xin-zhuan, PhD, White, Nicholas J, Prof, Dondorp, Arjen M, Prof, Anderson, Tim JC, Prof, Fay, Michael P, PhD, Mu, Jianbing, MD, Duong, Socheat, Prof, Fairhurst, Rick M, Dr

“…Summary Background Artemisinin-resistant Plasmodium falciparum has been reported in Pailin, western Cambodia, detected as a slow parasite clearance rate in…”
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Analysis of Plasmodium vivax schizont transcriptomes from field isolates reveals heterogeneity of expression of genes involved in host-parasite interactions by Siegel, Sasha V., Chappell, Lia, Hostetler, Jessica B., Amaratunga, Chanaki, Suon, Seila, Böhme, Ulrike, Berriman, Matthew, Fairhurst, Rick M., Rayner, Julian C.

“…Plasmodium vivax gene regulation remains difficult to study due to the lack of a robust in vitro culture method, low parasite densities in peripheral…”
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Functional Comparison of Plasmodium falciparum Transmission-Blocking Vaccine Candidates by the Standard Membrane-Feeding Assay by Miura, Kazutoyo, Takashima, Eizo, Deng, Bingbing, Tullo, Gregory, Diouf, Ababacar, Moretz, Samuel E, Nikolaeva, Daria, Diakite, Mahamadou, Fairhurst, Rick M, Fay, Michael P, Long, Carole A, Tsuboi, Takafumi

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Enhancing blockade of Plasmodium falciparum erythrocyte invasion: assessing combinations of antibodies against PfRH5 and other merozoite antigens by Williams, Andrew R, Douglas, Alexander D, Miura, Kazutoyo, Illingworth, Joseph J, Choudhary, Prateek, Murungi, Linda M, Furze, Julie M, Diouf, Ababacar, Miotto, Olivo, Crosnier, Cécile, Wright, Gavin J, Kwiatkowski, Dominic P, Fairhurst, Rick M, Long, Carole A, Draper, Simon J

“…No vaccine has yet proven effective against the blood-stages of Plasmodium falciparum, which cause the symptoms and severe manifestations of malaria. We…”
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Immunoscreening of Plasmodium falciparum proteins expressed in a wheat germ cell-free system reveals a novel malaria vaccine candidate by Morita, Masayuki, Takashima, Eizo, Ito, Daisuke, Miura, Kazutoyo, Thongkukiatkul, Amporn, Diouf, Ababacar, Fairhurst, Rick M., Diakite, Mahamadou, Long, Carole A., Torii, Motomi, Tsuboi, Takafumi

“…The number of malaria vaccine candidates in preclinical and clinical development is limited. To identify novel blood-stage malaria vaccine candidates, we…”
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Plasmodium falciparum picks (on) EPCR by Aird, William C., Mosnier, Laurent O., Fairhurst, Rick M.

“…Of all the outcomes of Plasmodium falciparum infection, the coma of cerebral malaria (CM) is particularly deadly. Malariologists have long wondered how some…”
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A barcode of organellar genome polymorphisms identifies the geographic origin of Plasmodium falciparum strains by Preston, Mark D., Campino, Susana, Assefa, Samuel A., Echeverry, Diego F., Ocholla, Harold, Amambua-Ngwa, Alfred, Stewart, Lindsay B., Conway, David J., Borrmann, Steffen, Michon, Pascal, Zongo, Issaka, Ouédraogo, Jean-Bosco, Djimde, Abdoulaye A., Doumbo, Ogobara K., Nosten, Francois, Pain, Arnab, Bousema, Teun, Drakeley, Chris J., Fairhurst, Rick M., Sutherland, Colin J., Roper, Cally, Clark, Taane G.

“…Malaria is a major public health problem that is actively being addressed in a global eradication campaign. Increased population mobility through international…”
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Artemisinin-Resistant Malaria: Research Challenges, Opportunities, and Public Health Implications by FAIRHURST, Rick M, NAYYAR, Gaurvika M. L, BREMAN, Joel G, HALLETT, Rachel, VENNERSTROM, Jonathan L, DUONG, Socheat, RINGWALD, Pascal, WELLEMS, Thomas E, PLOWE, Christopher V, DONDORP, Arjen M

“…Artemisinin-based combination therapies are the most effective drugs to treat Plasmodium falciparum malaria. Reduced sensitivity to artemisinin monotherapy,…”
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A Library of Plasmodium vivax Recombinant Merozoite Proteins Reveals New Vaccine Candidates and Protein-Protein Interactions by Hostetler, Jessica B, Sharma, Sumana, Bartholdson, S Josefin, Wright, Gavin J, Fairhurst, Rick M, Rayner, Julian C

“…A vaccine targeting Plasmodium vivax will be an essential component of any comprehensive malaria elimination program, but major gaps in our understanding of P…”
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PfEMP1’s Magical Embrace of EPCR by Fairhurst, Rick M.

“…Since discovering PfEMP1 virulence proteins in Plasmodium falciparum, malariologists have struggled to reconcile their limitless sequence diversity with their…”
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