Search Results - "Faircloth, G. T."

Ecteinascidin-743 (ET-743), a natural marine compound, with a unique mechanism of action by Erba, E, Bergamaschi, D, Bassano, L, Damia, G, Ronzoni, S, Faircloth, G.T, D'Incalci, M

“…The mode of action of Ecteinascidin-743 (ET-743), a marine tetrahydroisoquinoline alkaloid isolated from Ecteinascidia turbinata, which has shown very potent…”
Get full text

Aplidine, a new anticancer agent of marine origin, inhibits vascular endothelial growth factor (VEGF) secretion and blocks VEGF-VEGFR-1 ( ) autocrine loop in human leukemia cells MOLT-4 by Broggini, M, Marchini, S V, Galliera, E, Borsotti, P, Taraboletti, G, Erba, E, Sironi, M, Jimeno, J, Faircloth, G T, Giavazzi, R, D'Incalci, M

“…The mechanism by which aplidine, a marine natural product in early clinical development as an anticancer agent, induces cell growth inhibition and apoptosis…”
Get full text

Antiangiogenic activity of aplidine, a new agent of marine origin by TARABOLETTI, G, POLI, M, DOSSI, R, MANENTI, L, BORSOTTI, P, FAIRCLOTH, G. T, BROGGINI, M, D'INCALCI, M, RIBATTI, D, GIAVAZZI, R

“…The antineoplastic compound aplidine, a new marine-derived depsipeptide, has shown preclinical activity in vitro on haematological and solid tumour cell lines…”
Get full text

Effect of Aplidin in acute lymphoblastic leukaemia cells by ERBA, E, SERAFINI, M, BIONDI, A, D'INCALCI, M, GAIPA, G, TOGNON, G, MARCHINI, S, CELLI, N, ROTILIO, D, BROGGINI, M, JIMENO, J, FAIRCLOTH, G. T

“…The cytotoxic effect of Aplidin was investigated on fresh leukaemia cells derived from children with B-cell-precursor (BCP) acute lymphoblastic leukaemia (ALL)…”
Get full text

High antitumour activity of ET743 against human tumour xenografts from melanoma, non-small-cell lung and ovarian cancer by Hendriks, H. R., Fiebig, H. H., Giavazzi, R., Langdon, S. P., Jimeno, J. M., Faircloth, G. T.

“…Background: Ecteinascidin-743 (ET743) is a novel antitumour agent originating from the Caribbean tunicate Ecteinascidia turbinata. It has potent cytotoxic and…”
Get full text

Molecular characterisation of two human cancer cell lines selected in vitro for their chemotherapeutic drug resistance to ET-743 by Marchini, S., Marrazzo, E., Bonomi, R., Chiorino, G., Zaffaroni, M., Weissbach, L., Hornicek, F.J., Broggini, M., Faircloth, G.T., D’Incalci, M.

“…ET-743 (Yondelis TM, Trabectedin) isolated from the tunicate Ecteinascidia turbinata, is being tested in phase II clinical trials in Europe and the United…”
Get full text

In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells by DEPENBROCK, H, PETER, R, FAIRCLOTH, G. T, MANZANARES, I, JIMENO, J, HANAUSKE, A. R

“…Aplidine is a new marine anti-cancer depsipeptide isolated from the Mediterranean tunicate Aplidium albicans. We have evaluated its antiproliferative action…”
Get full text

In vitro interaction between ecteinascidin 743 (ET-743) and radiation, in relation to its cell cycle effects by SIMOENS, C, KORST, A. E. C, DE POOTER, C. M. J, LAMBRECHTS, H. A. J, PATTYN, G. G. O, FAIRCLOTH, G. T, LARDON, F, VERMORKEN, J. B

“…Ecteinascidin 743 (ET-743) is a new marine-derived agent with promising activity against a number of solid tumours. In four human tumour cell lines, the…”
Get full text

The combination of yondelis and cisplatin is synergistic against human tumor xenografts by D'Incalci, M., Colombo, T., Ubezio, P., Nicoletti, I., Giavazzi, R., Erba, E., Ferrarese, L., Meco, D., Riccardi, R., Sessa, C., Cavallini, E., Jimeno, J., Faircloth, G.T.

“…Yondelis™ (trabectidin, ET-743) is a marine natural product that has shown activity both in preclinical systems and in human malignancies such as soft tissue…”
Get full text

In vitro cytotoxicity of aplidin and crossresistance with other cytotoxic drugs in childhood leukemic and normal bone marrow and blood samples: a rational basis for clinical development by BRESTERS, D, BROEKHUIZEN, A. J. F, KAAIJK, P, FAIRCLOTH, G. T, JIMENO, J, KASPERS, G. J. L

“…To determine the potential of aplidin as a cytotoxic agent in pediatric leukemia, we tested bone marrow (BM) and peripheral blood (PB) samples (n=72) of…”
Get full text

The unique biological features of the marine product Yondelis (ET-743, trabectedin) are shared by its analog ET-637, which lacks the C ring by Erba, E, Cavallaro, E, Damia, G, Mantovani, R, Di Silvio, A, Di Francesco, A M, Riccardi, R, Cuevas, C, Faircloth, G T, D'Incalci, M

“…It was previously suggested that the peculiar mechanism of action of the novel anticancer drug Yondelis (ET-743, trabectedin) was due to part of the molecule,…”
Get more information

Evaluation of the use of in vitro methodologies as tools for screening new compounds for potential in vivo toxicity by Luber-Narod, J, Smith, B, Grant, W, Jimeno, J.M, López-Lázaro, L, Faircloth, G.T

“…Our laboratory has begun work on an in vitro screening system designed to determine which experimental drugs are most likely to be safe candidates for…”
Get full text

Cytotoxicity and neurocytotoxicity of new marine anticancer agents evaluated using in vitro assays by GELDOF, A. A, MASTBERGEN, S. C, HENRAR, R. E. C, FAIRCLOTH, G. T

“…New classes of anticancer drugs, isolated from marine organisms, have been shown to possess cytotoxic activity against multiple tumor types. Aplidine, didemnin…”
Get full text

Immunosuppressive Cyclolignans by Gordaliza, Marina, Faircloth, Glynn T, Castro, Ma Angeles, Miguel del Corral, José M, López-Vázquez, Ma Luisa, San Feliciano, Arturo

“…The immunosuppressive activity of several lactonic, nonlactonic, and heterocycle-fused cyclolignans has been demonstrated for the first time by use of a…”
Get full text

Unique pattern of ET‐743 activity in different cellular systems with defined deficiencies in DNA‐repair pathways by Damia, Giovanna, Silvestri, Simonetta, Carrassa, Laura, Filiberti, Laura, Faircloth, Glynn T., Liberi, Giordano, Foiani, Marco, D'Incalci, Maurizio

“…The cytotoxic activity of ecteinascidin 743 (ET‐743), a natural product derived from the marine tunicate Ecteinascidia turbinata that exhibits potent…”
Get full text

Changes in gene expression profile induced by the anticancer agent Aplidine in Molt-4 leukemic cell lines by Marchini, S, Chiorino, G, Faircloth, G T, D'Incalci, M

“…Microarray technique was employed to study differences in gene expression profile induced by Aplidine treatment in the Molt-4 human leukemic T cell line…”
Get more information

Differential subcellular distribution of bioactive human chorionic gonadotropin in pseudopregnant rat ovary by Gilligan, A, Kawamura, H, Faircloth, G T, Vaitukaitis, J L

“…The subcellular metabolism of internalized hCG was examined by monitoring the distribution of bioactive and immunoreactive hCG in subcellular fractions of…”
Get more information

Metabolism of luteinizing hormone by the pseudopregnant rat ovary by Rorke, E A, Faircloth, G T, Vaitukaitis, J L

“…Ovarian metabolism of highly purified human LH (hLH) was studied in pseudopregnant rats. The animals were injected with 1.0 microgram (11.1 IU) hLH, iv, and…”
Get more information

In vivo immunosuppressive activity of some cyclolignans by Gordaliza, Marina, Castro, MaAngeles, Miguel del Corral, JoséMa, López-Vázquez, MaLuisa, San Feliciano, Arturo, Faircloth, Glynn T.

“…Several podophyllotoxin-related cyclolignans, either lacking the lactone ring or the methylenedioxy grouping, have been prepared and evaluated for their…”
Get full text

New acetylenic alcohols from the sponge Cribrochalina vasculum by Gunasekera, Sarath P, Faircloth, Glynn T

Get full text