Search Results - "Fairbanks, CA"

Spinal delivery of analgesics in experimental models of pain and analgesia by Fairbanks, Carolyn A

“…Systemic administration of analgesics can lead to serious adverse side effects compromising therapeutic benefit in some patients. Information coding pain…”
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Agmatine Reverses Pain Induced by Inflammation, Neuropathy, and Spinal Cord Injury by Fairbanks, Carolyn A., Schreiber, Kristin L., Brewer, Kori L., Yu, Chen-Guang, Stone, Laura S., Kitto, Kelley F., Nguyen, H. Oanh, Grocholski, Brent M., Shoeman, Don W., Kehl, Lois J., Regunathan, Soundararajan, Reis, Donald J., Yezierski, Robert P., Wilcox, George L.

“…Antagonists of glutamate receptors of the N-methyl-D-aspartate subclass (NMDAR) or inhibitors of nitric oxide synthase (NOS) prevent nervous system plasticity…”
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Spinal antinociceptive synergism between morphine and clonidine persists in mice made acutely or chronically tolerant to morphine by Fairbanks, C A, Wilcox, G L

“…Morphine (Mor) tolerance has been attributed to a reduction of opioid-adrenergic antinociceptive synergy at the spinal level. The present experiments tested…”
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Effects of agmatine, interleukin-10, and cyclosporin on spontaneous pain behavior after excitotoxic spinal cord injury in rats by Yu, Chen-Guang, Fairbanks, Carolyn A, Wilcox, George L, Yezierski, Robert P

“…Intraspinal injection of the AMPA/metabotropic receptor agonist quisqualic acid (QUIS) results in a pathophysiology that leads to excessive grooming behavior,…”
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Disruption of nNOS‐PSD95 protein–protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents by Florio, SK, Loh, C, Huang, SM, Iwamaye, AE, Kitto, KF, Fowler, KW, Treiberg, JA, Hayflick, JS, Walker, JM, Fairbanks, CA, Lai, Y

“…Background and purpose:  Post‐synaptic density protein 95 (PSD95) contains three PSD95/Dosophilia disc large/ZO‐1 homology domains and links neuronal nitric…”
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Acute tolerance to spinally administered morphine compares mechanistically with chronically induced morphine tolerance by Fairbanks, C A, Wilcox, G L

“…The mechanistic similarity between acutely and chronically induced morphine tolerance has been previously proposed but remains largely unexplored. Our…”
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Spinal plasticity of acute opioid tolerance by Fairbanks, C A, Wilcox, G L

“…Spinal acute opioid tolerance remains mechanistically undercharacterized. Expanded clinical use of direct spinal administration of opioids and other analgesics…”
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Pharmacological profiles of alpha 2 adrenergic receptor agonists identified using genetically altered mice and isobolographic analysis by Fairbanks, Carolyn A, Stone, Laura S, Wilcox, George L

“…Endogenous, descending noradrenergic fibers impose analgesic control over spinal afferent circuitry mediating the rostrad transmission of pain signals. These…”
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alpha(2C)-Adrenergic receptors mediate spinal analgesia and adrenergic-opioid synergy by Fairbanks, Carolyn A, Stone, Laura S, Kitto, Kelley F, Nguyen, H Oanh, Posthumus, Ivan J, Wilcox, George L

“…The alpha(2A)-adrenergic receptor (AR) subtype mediates antinociception induced by the alpha(2)AR agonists clonidine, dexmedetomidine, norepinephrine, and…”
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Transcutaneous electrical nerve stimulation activates peripherally located alpha-2A adrenergic receptors by King, Ellen W., Audette, Katherine, Athman, Gwendolyn A., Nguyen, H. Oanh X., Sluka, Kathleen A., Fairbanks, Carolyn A.

“…The alpha 2A and alpha 2C adrenergic receptor (AR) subtypes mediate antinociception when activated by the endogenous ligand norepinephrine. These receptors…”
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Pharmacodynamic and pharmacokinetic studies of agmatine after spinal administration in the mouse by Roberts, John C, Grocholski, Brent M, Kitto, Kelley F, Fairbanks, Carolyn A

“…Agmatine is an endogenous decarboxylation product of arginine that has been previously shown to antagonize the N-methyl-d-aspartate (NMDA) receptor and inhibit…”
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Supraspinally administered agmatine prevents the development of supraspinal morphine analgesic tolerance by Kitto, Kelley F., Fairbanks, Carolyn A.

“…We have determined the effect of intracerebroventricularly (i.c.v.) administered decarboxylated arginine (agmatine) on supraspinally induced chronic morphine…”
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Spinal analgesic actions of the new endogenous opioid peptides endomorphin-1 and -2 by Stone, Laura S, Fairbanks, Carolyn A, Laughlin, Tinna M, Nguyen, H Oanh, Bushy, Tina M, Wessendorf, Martin W, Wilcox, George L

“…TWO highly-selective μ-opioid receptor agonists, endomorphin-1 and -2, were recently purified from bovine brain and are postulated to be endogenous μ-opioid…”
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Release of tritiated agmatine from spinal synaptosomes by Goracke-Postle, Cory J, Nguyen, Hoang Oanh X, Stone, Laura S, Fairbanks, Carolyn A

“…Intrathecal agmatine (decarboxylated arginine) moderates induction of neuropathic pain, spinal cord injury, and opioid tolerance in rodents. An endogenous…”
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Developmental shift of vanilloid receptor 1 (VR1) terminals into deeper regions of the superficial dorsal horn: correlation with a shift from TrkA to Ret expression by dorsal root ganglion neurons by Guo, A., Simone, D. A., Stone, L. S., Fairbanks, C. A., Wang, J., Elde, R.

“…The cloned vanilloid receptor VR1 can be activated by capsaicin and by thermal stimuli. The pattern of nerve terminals that contain VR1 in adult rat spinal…”
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Agmatine improves locomotor function and reduces tissue damage following spinal cord injury by Yu, Chen Guang, Marcillo, Alex E, Fairbanks, Carolyn A, Wilcox, George L, Yezierski, Robert P

“…Clinically effective drug treatments for spinal cord injury (SCI) remain unavailable. Agmatine, an NMDA receptor antagonist and inhibitor of nitric oxide…”
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Neuropharmacokinetic and Dynamic Studies of Agmatine (Decarboxylated Arginine) by NGUYEN, H OANH X., GORACKE-POSTLE, CORY J., KAMINSKI, LORI L., OVERLAND, AARON C., MORGAN, ANDREW D., FAIRBANKS, CAROLYN A.

“…: Agmatine has been previously proposed to represent a novel neurotransmitter. One of the criteria required to test that hypothesis is that the exogenously…”
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Transgenic mice possessing increased numbers of nociceptors do not exhibit increased behavioral sensitivity in models of inflammatory and neuropathic pain by Zwick, Melissa, Molliver, Derek C, Lindsay, Jessica, Fairbanks, Carolyn A, Sengoku, Tomoko, Albers, Kathryn M, Davis, Brian M

“…At least two classes of nociceptors can be distinguished based on their growth factor requirements: glial cell-line derived neurotrophic factor (GDNF)- and…”
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Moxonidine, a mixed alpha(2)-adrenergic and imidazoline receptor agonist, identifies a novel adrenergic target for spinal analgesia by Stone, Laura S, Fairbanks, Carolyn A, Wilcox, George L

“…Moxonidine is a mixed alpha(2)-adrenergic and imidazoline receptor agonist with an improved side effect profile compared to clonidine. Intrathecal (i.t.)…”
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Experimental animal models of muscle pain and analgesia by Kehl, Lois J, Fairbanks, Carolyn A

“…Muscle pain is a prevalent clinical problem but can be difficult to treat because relatively little is known about nervous system mechanisms that mediate and…”
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