Search Results - "Fain, Gordon L."

Lamprey vision: Photoreceptors and organization of the retina by Fain, Gordon L.

“…The lamprey is an important non-model vertebrate because it is an agnathan or jawless vertebrate and belongs to the superclass cyclostomata, a group that split…”
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Elevated energy requirement of cone photoreceptors by Ingram, Norianne T., Fain, Gordon L., Sampath, Alapakkam P.

“…We have used recent measurements of mammalian cone light responses and voltage-gated currents to calculate cone ATP utilization and compare it to that of rods…”
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Why are rods more sensitive than cones? by Ingram, Norianne T., Sampath, Alapakkam P., Fain, Gordon L.

“…One hundred and fifty years ago Max Schultze first proposed the duplex theory of vision, that vertebrate eyes have two types of photoreceptor cells with…”
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Single-Photon Sensitivity of Lamprey Rods with Cone-like Outer Segments by Morshedian, Ala, Fain, Gordon L.

“…Most vertebrates have a duplex retina containing rods for dim light vision and cones for bright lights and color detection. Photoreceptors like cones are…”
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Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in Müller Glial Cells by Morshedian, Ala, Kaylor, Joanna J., Ng, Sze Yin, Tsan, Avian, Frederiksen, Rikard, Xu, Tongzhou, Yuan, Lily, Sampath, Alapakkam P., Radu, Roxana A., Fain, Gordon L., Travis, Gabriel H.

“…While rods in the mammalian retina regenerate rhodopsin through a well-characterized pathway in cells of the retinal pigment epithelium (RPE), cone visual…”
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Phototransduction and the Evolution of Photoreceptors by Fain, Gordon L., Hardie, Roger, Laughlin, Simon B.

“…Photoreceptors in metazoans can be grouped into two classes, with their photoreceptive membrane derived either from cilia or microvilli. Both classes use some…”
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Light adaptation and the evolution of vertebrate photoreceptors by Morshedian, Ala, Fain, Gordon L.

“…Key Points Lamprey are cyclostomes, a group of vertebrates that diverged from lines leading to jawed vertebrates (including mammals) in the late Cambrian,…”
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Genetic manipulation of rod-cone differences in mouse retina by Morshedian, Ala, Jiang, Zhichun, Radu, Roxana A, Fain, Gordon L, Sampath, Alapakkam P

“…Though rod and cone photoreceptors use similar phototransduction mechanisms, previous model calculations have indicated that the most important differences in…”
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ATP Consumption by Mammalian Rod Photoreceptors in Darkness and in Light by Okawa, Haruhisa, Sampath, Alapakkam P., Laughlin, Simon B., Fain, Gordon L.

“…Why do vertebrates use rods and cones that hyperpolarize, when in insect eyes a single depolarizing photoreceptor can function at all light levels [1, 2]? We…”
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The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx by Wang, Tian, Reingruber, Jürgen, Woodruff, Michael L., Majumder, Anurima, Camarena, Andres, Artemyev, Nikolai O., Fain, Gordon L., Chen, Jeannie

“…The retinal degeneration model rd10 contains a missense mutation of the catalytic PDE6 β subunit, which hydrolyzes cGMP in response to light. This model…”
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Rod Photoreceptors Avoid Saturation in Bright Light by the Movement of the G Protein Transducin by Frederiksen, Rikard, Morshedian, Ala, Tripathy, Sonia A, Xu, Tongzhou, Travis, Gabriel H, Fain, Gordon L, Sampath, Alapakkam P

“…Rod photoreceptors can be saturated by exposure to bright background light, so that no flash superimposed on the background can elicit a detectable response…”
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Phototransduction: Making the Chromophore to See Through the Murk by Fain, Gordon L.

“…A candidate gene approach has finally identified the 3,4-dehydrogenase that converts vitamin A1 into vitamin A2 to supply the chromophore for rhodopsin that…”
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A kinetic analysis of mouse rod and cone photoreceptor responses by Reingruber, Jürgen, Ingram, Norianne T., Griffis, Khris G., Fain, Gordon L.

“…Key points Most vertebrate eyes have rods for dim‐light vision and cones for brighter light and higher temporal sensitivity. Rods evolved from cone‐like…”
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Role of recoverin in rod photoreceptor light adaptation by Morshedian, Ala, Woodruff, Michael L., Fain, Gordon L.

“…Key points Recoverin is a small molecular‐weight, calcium‐binding protein in rod outer segments that can modulate the rate of rhodopsin phosphorylation. We…”
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A Novel Role for UNC119 as an Enhancer of Synaptic Transmission by Fehlhaber, Katherine E, Majumder, Anurima, Boyd, Kimberly K, Griffis, Khris G, Artemyev, Nikolai O, Fain, Gordon L, Sampath, Alapakkam P

“…Mammalian UNC119 is a ciliary trafficking chaperone highly expressed in the inner segment of retinal photoreceptors. Previous research has shown that UNC119…”
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Blue light regenerates functional visual pigments in mammals through a retinyl-phospholipid intermediate by Kaylor, Joanna J., Xu, Tongzhou, Ingram, Norianne T., Tsan, Avian, Hakobyan, Hayk, Fain, Gordon L., Travis, Gabriel H.

“…The light absorbing chromophore in opsin visual pigments is the protonated Schiff base of 11- cis- retinaldehyde (11cRAL). Absorption of a photon isomerizes…”
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Detection of single photons by toad and mouse rods by Reingruber, Jürgen, Pahlberg, Johan, Woodruff, Michael L., Sampath, Alapakkam P., Fain, Gordon L., Holcman, David

“…Amphibian and mammalian rods can both detect single photons of light even though they differ greatly in physical dimensions, mammalian rods being much smaller…”
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Why photoreceptors die (and why they don't) by Fain, Gordon L.

“…Light can kill the photoreceptors of the eye, not only very bright direct sunlight, but more moderate illumination if the light is present continuously. Recent…”
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The mechanism of genetically inherited night blindness by Fain, Gordon L

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Channel modulation and the mechanism of light adaptation in mouse rods by Chen, Jeannie, Woodruff, Michael L, Wang, Tian, Concepcion, Francis A, Tranchina, Daniel, Fain, Gordon L

“…Vertebrate photoreceptors are thought to adapt to light by a change in Ca(2+), which is postulated to mediate modulation of (1) excited rhodopsin (Rh*) by…”
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