Search Results - "Fahien, L A"

Regulation of insulin release by factors that also modify glutamate dehydrogenase by Fahien, L A, MacDonald, M J, Kmiotek, E H, Mertz, R J, Fahien, C M

“…Leucine and monomethyl succinate initiate insulin release, and glutamine potentiates leucine-induced insulin release. Alanine enhances and malate inhibits…”
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Glutamate-malate metabolism in liver mitochondria. A model constructed on the basis of mitochondrial levels of enzymes, specificity, dissociation constants, and stoichiometry of hetero-enzyme complexes by FAHIEN, L. A, TELLER, J. K

“…The level of aspartate aminotransferase in liver mitochondria was found to be approximately 140 microM, or 2-3 orders of magnitude higher than its dissociation…”
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Glutamate Is Not a Messenger in Insulin Secretion by MacDonald, Michael J., Fahien, Leonard A.

“…Experiments do not support a recent claim that glutamate formed from the amination of citric acid cycle-derived α-ketoglutarate is a messenger in…”
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Regulation of malate dehydrogenase activity by glutamate, citrate, alpha-ketoglutarate, and multienzyme interaction by Fahien, L A, Kmiotek, E H, MacDonald, M J, Fibich, B, Mandic, M

“…Binding experiments indicate that mitochondrial aspartate aminotransferase can associate with the alpha-ketoglutarate dehydrogenase complex and that…”
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Kinetics and regulation of hepatoma mitochondrial NAD(P) malic enzyme by TELLER, J. K, FAHIEN, L. A, DAVIS, J. W

“…Kinetic studies of Morris 7777 hepatoma mitochondrial NAD(P) malic enzyme were consistent with an ordered mechanism where NAD adds to the enzyme before malate…”
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Interactions between pyruvate carboxylase and other mitochondrial enzymes by Fahien, L.A., Davis, J.W., Laboy, J.

“…Although pyruvate carboxylase associated with both mitochondrial aspartate aminotransferase and malate dehydrogenase, it had a higher affinity for the…”
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Kinetic Advantages of Hetero-Enzyme Complexes with Glutamate Dehydrogenase and the α-Ketoglutarate Dehydrogenase Complex by Fahien, L A, MacDonald, M J, Teller, J K, Fibich, B, Fahien, C M

“…We have found previously (Fahien, L. A., Kmiotek, E. H., MacDonald, M. J., Fibich, B., and Mandic, M. (1988) J. Biol. Chem. 263, 10687–10697) that…”
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Glyceraldehyde phosphate and methyl esters of succinic acid: two new potent insulin secretagogues by MACDONALD, M. J, FAHIEN, L. A

“…We discovered that two physiologically occurring metabolic intermediates, glyceraldehyde phosphate and succinate, are potent insulin secretagogues. No other…”
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Interactions among mitochondrial aspartate aminotransferase, malate dehydrogenase, and the inner mitochondrial membrane from heart, hepatoma, and liver by Teller, J K, Fahien, L A, Valdivia, E

“…The inner mitochondrial membranes from bovine heart, rat liver, and Morris hepatoma 7777 all bound the mitochondrial isozymes of aspartate aminotransferase and…”
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Glucose regulates leucine-induced insulin release and the expression of the branched chain ketoacid dehydrogenase E1 alpha subunit gene in pancreatic islets by MacDonald, M J, McKenzie, D I, Kaysen, J H, Walker, T M, Moran, S M, Fahien, L A, Towle, H C

“…Much evidence has accumulated to support the idea that leucine can stimulate insulin release by allosterically activating glutamate dehydrogenase thus…”
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Novel effects of insulin secretagogues on capacitation of insulin release and survival of cultured pancreatic islets by MacDonald, M J, Fahien, L A, McKenzie, D I, Moran, S M

“…Agents that stimulate insulin release from fresh pancreatic islets were tested for their ability to capacitate pancreatic islets to secrete insulin and to…”
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Effect of esters of succinic acid and other citric acid cycle intermediates on insulin release and inositol phosphate formation by pancreatic islets by MacDonald, M J, Fahien, L A, Mertz, R J, Rana, R S

“…Esters of carboxylic acids are permeable to cells and once inside the cell are hydrolyzed to carboxylic acids. Methyl and ethyl esters of succinate and other…”
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Proteolysis as a probe of ligand-associated conformational changes in rat carbamyl phosphate synthetase I by Marshall, M, Fahien, L A

“…Elastase, V8 protease, subtilisin, trypsin, and chymotrypsin all cleaved the 1462-residue polypeptide of rat carbamyl phosphate synthetase I in segment C…”
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Regulation of glutamate dehydrogenase by Mg2+ and magnification of leucine activation by Mg2 by Fahien, L A, Teller, J K, Macdonald, M J, Fahien, C M

“…In the presence of Mg2+, pure glutamate dehydrogenase is more reactive with NADPH than with NADH and is markedly activated by elevations in the ADP/ATP ratio…”
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Precipitation of complexes between glutamate dehydrogenase and mitochondrial enzymes by Fahien, L.A, Kmiotek, E

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Effect of aspartate on complexes between glutamate dehydrogenase and various aminotransferases by Fahien, L.A, Hsu, S.L, Kmiotek, E

“…In previous studies it was found that: (a) aspartate aminotransferase increases the aspartate dehydrogenase activity of glutamate dehydrogenase; (b) the…”
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Regulation of aminotransferase-glutamate dehydrogenase interactions by carbamyl phosphate synthase-I, Mg2+ plus leucine versus citrate and malate by Fahien, L A, Kmiotek, E H, Woldegiorgis, G, Evenson, M, Shrago, E, Marshall, M

“…Citrate, malate, and high levels of ATP dissociate the mitochondrial aspartate aminotransferase-glutamate dehydrogenase complex and have an inhibitory effect…”
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Effect of NADH-X on Cytosolic Glycerol-3-phosphate Dehydrogenase by Prabhakar, Prakash, Laboy, José I., Wang, Jianbo, Budker, Tatyana, Din, Zafeeer Z., Chobanian, Michael, Fahien, Leonard A.

“…At pH 7.05 NADH-X prepared by incubating NADH with glyceraldehyde-3-phosphate dehydrogenase (E.C. 1.2.1.12) was a potent noncompetitive inhibitor, with respect…”
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Effects of chlorpromazine on glutamate dehydrogenase by Fahien, L A, Shemisa, O

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Modifications of glutamate dehydrogenase by various drugs which affect behavior by Shemisa, O A, Fahien, L A

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