Search Results - "Faham, S."

Predicting allosteric mutants that increase activity of a major antibiotic resistance enzyme by Latallo, M J, Cortina, G A, Faham, S, Nakamoto, R K, Kasson, P M

“…The CTX-M family of beta lactamases mediate broad-spectrum antibiotic resistance and are present in the majority of drug-resistant Gram-negative bacterial…”
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Clinical and genetic characteristics of 15 families with hereditary hypophosphatemia: Novel Mutations in PHEX and SLC34A3 by Acar, Sezer, BinEssa, Huda A, Demir, Korcan, Al-Rijjal, Roua A, Zou, Minjing, Çatli, Gönül, Anık, Ahmet, Al-Enezi, Anwar F, Özışık, Seçil, Al-Faham, Manar S A, Abacı, Ayhan, Dündar, Bumin, Kattan, Walaa E, Alsagob, Maysoon, Kavukçu, Salih, Tamimi, Hamdi E, Meyer, Brian F, Böber, Ece, Shi, Yufei

“…Hereditary hypophosphatemia is a group of rare renal phosphate wasting disorders. The diagnosis is based on clinical, radiological, and biochemical features,…”
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Bicelle crystallization: a new method for crystallizing membrane proteins yields a monomeric bacteriorhodopsin structure by Faham, Salem, Bowie, James U

“…Obtaining crystals of membrane proteins that diffract to high resolution remains a major stumbling block in structure determination. Here we present a new…”
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Molecular Analysis of Congenital Hypothyroidism in Saudi Arabia: SLC26A7 Mutation Is a Novel Defect in Thyroid Dyshormonogenesis by Zou, Minjing, Alzahrani, Ali S, Al-Odaib, Ali, Alqahtani, Mohammad A, Babiker, Omer, Al-Rijjal, Roua A, BinEssa, Huda A, Kattan, Walaa E, Al-Enezi, Anwar F, Al Qarni, Ali, Al-Faham, Manar S A, Baitei, Essa Y, Alsagheir, Afaf, Meyer, Brian F, Shi, Yufei

“…Abstract Context Congenital hypothyroidism (CH) is the most common neonatal endocrine disorder, affecting one in 3000 to 4000 newborns. Since the introduction…”
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Heparin Structure and Interactions with Basic Fibroblast Growth Factor by Faham, S., Hileman, R. E., Fromm, J. R., Linhardt, R. J., Rees, D. C.

“…Crystal structures of heparin-derived tetra- and hexasaccharides complexed with basic fibroblast growth factor (bFGF) were determined at resolutions of 1.9 and…”
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Polymerization of the SAM domain of TEL in leukemogenesis and transcriptional repression by Kim, Chongwoo A., Phillips, Martin L., Kim, Woojae, Gingery, Mari, Tran, Hoang H., Robinson, Michael A., Faham, Salem, Bowie, James U.

“…TEL is a transcriptional repressor that is a frequent target of chromosomal translocations in a large number of hematalogical malignancies. These…”
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Functional analysis of 22 splice-site mutations in the PHEX, the causative gene in X-linked dominant hypophosphatemic rickets by BinEssa, Huda A., Zou, Minjing, Al-Enezi, Anwar F., Alomrani, Basma, Al-Faham, Manar S.A., Al-Rijjal, Roua A., Meyer, Brian F., Shi, Yufei

“…X-linked hypophosphatemic rickets (XLH) is caused by inactivating mutations in the PHEX gene and is the most common form of hereditary rickets. The splice-site…”
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Three-Dimensional Structures of Acidic and Basic Fibroblast Growth Factors by Zhu, X., Komiya, H., Chirino, A., Faham, S., Fox, G. M., Arakawa, T., Hsu, B. T., Rees, D. C.

“…Members of the fibroblast growth factor (FGF) family of proteins stimulate the proliferation and differentiation of a variety of cell types through…”
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The Crystal Structure of Mouse VDAC1 at 2.3 Å Resolution Reveals Mechanistic Insights into Metabolite Gating by Ujwal, Rachna, Cascio, Duilio, Colletier, Jacques-Philippe, Faham, Salem, Zhang, Jun, Toro, Ligia, Ping, Peipei, Abramson, Jeff

“…The voltage-dependent anion channel (VDAC) constitutes the major pathway for the entry and exit of metabolites across the outer membrane of the mitochondria…”
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Crystal Structure of a Sodium Galactose Transporter Reveals Mechanistic Insights into Na⁺/Sugar Symport by Faham, Salem, Watanabe, Akira, Besserer, Gabriel Mercado, Cascio, Duilio, Specht, Alexandre, Hirayama, Bruce A, Wright, Ernest M, Abramson, Jeff

“…Membrane transporters that use energy stored in sodium gradients to drive nutrients into cells constitute a major class of proteins. We report the crystal…”
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Predicting allosteric mutants that increase activity of a major antibiotic resistance enzymeElectronic supplementary information (ESI) available. See DOI: 10.1039/c7sc02676e by Latallo, M. J, Cortina, G. A, Faham, S, Nakamoto, R. K, Kasson, P. M

“…The CTX-M family of beta lactamases mediate broad-spectrum antibiotic resistance and are present in the majority of drug-resistant Gram-negative bacterial…”
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Predicting allosteric mutants that increase activity of a major antibiotic resistance enzyme† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc02676e Click here for additional data file by Latallo, M. J., Cortina, G. A., Faham, S., Nakamoto, R. K., Kasson, P. M.

“…Allosteric mutations increasing k cat in a beta lactamase act by changing conformational ensembles of active-site residues identified by machine learning. The…”
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An Architectural Framework That May Lie at the Core of the Postsynaptic Density by Baron, Marisa K., Boeckers, Tobias M., Vaida, Bianca, Faham, Salem, Gingery, Mari, Sawaya, Michael R., Salyer, Danielle, Gundelfinger, Eckart D., Bowie, James U.

“…The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling…”
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The Evolution of Transmembrane Helix Kinks and the Structural Diversity of G Protein-Coupled Receptors by Yohannan, Sarah, Faham, Salem, Yang, Duan, Whitelegge, Julian P., Bowie, James U.

“…One of the hallmarks of membrane protein structure is the high frequency of transmembrane helix kinks, which commonly occur at proline residues. Because the…”
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Side-chain Contributions to Membrane Protein Structure and Stability by Faham, Salem, Yang, Duan, Bare, Emiko, Yohannan, Sarah, Whitelegge, Julian P., Bowie, James U.

“…The molecular forces that stabilize membrane protein structure are poorly understood. To investigate these forces we introduced alanine substitutions at 24…”
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Crystallization of bacteriorhodopsin from bicelle formulations at room temperature by Faham, Salem, Boulting, Gabriella L., Massey, Elizabeth A., Yohannan, Sarah, Yang, Dawn, Bowie, James U.

“…We showed previously that high‐quality crystals of bacteriorhodopsin (bR) from Halobacterium salinarum can be obtained from bicelle‐forming DMPC/CHAPSO…”
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Proline substitutions are not easily accommodated in a membrane protein by Yohannan, Sarah, Yang, Duan, Faham, Salem, Boulting, Gabriella, Whitelegge, Julian, Bowie, James U

“…Proline residues are relatively common in transmembrane helices. This suggests that proline substitutions may be readily tolerated in membrane proteins, even…”
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Formaldehyde ferredoxin oxidoreductase from Pyrococcus furiosus: the 1.85 A resolution crystal structure and its mechanistic implications by Hu, Y, Faham, S, Roy, R, Adams, M W, Rees, D C

“…Crystal structures of formaldehyde ferredoxin oxidoreductase (FOR), a tungstopterin-containing protein from the hyperthermophilic archaeon Pyrococcus furiosus,…”
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Diversity does make a difference: fibroblast growth factor-heparin interactions by Faham, Salem, Linhardt, Robert J, Rees, Douglas C

“…Fibroblast growth factors (FGFs) are members of a protein family with a broad range of biological activities. The best characterized FGFs interact with two…”
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Monomeric structure of the human EphB2 sterile alpha motif domain by Thanos, C D, Faham, S, Goodwill, K E, Cascio, D, Phillips, M, Bowie, J U

“…The sterile alpha motif (SAM) domain is a protein module found in many diverse signaling proteins. SAM domains in some systems have been shown to…”
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