Search Results - "Fahad, Ahmed S"

Ultrasonically-guided flow focusing generates precise emulsion droplets for high-throughput single cell analyses by Lagerman, Colton E., López Acevedo, Sheila N., Fahad, Ahmed S., Hailemariam, Amen T., Madan, Bharat, DeKosky, Brandon J.

“…Emulsion-based techniques have dramatically advanced our understanding of single-cell biology and complex single-cell features over the past two decades. Most…”
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Prevalence of Propionibacterium acnes in Intervertebral Discs of Patients Undergoing Lumbar Microdiscectomy: A Prospective Cross-Sectional Study by Capoor, Manu N, Ruzicka, Filip, Machackova, Tana, Jancalek, Radim, Smrcka, Martin, Schmitz, Jonathan E, Hermanova, Marketa, Sana, Jiri, Michu, Elleni, Baird, John C, Ahmed, Fahad S, Maca, Karel, Lipina, Radim, Alamin, Todd F, Coscia, Michael F, Stonemetz, Jerry L, Witham, Timothy, Ehrlich, Garth D, Gokaslan, Ziya L, Mavrommatis, Konstantinos, Birkenmaier, Christof, Fischetti, Vincent A, Slaby, Ondrej

“…The relationship between intervertebral disc degeneration and chronic infection by Propionibacterium acnes is controversial with contradictory evidence…”
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Pro-Inflammatory and Neurotrophic Factor Responses of Cells Derived from Degenerative Human Intervertebral Discs to the Opportunistic Pathogen Cutibacterium acnes by Capoor, Manu N, Konieczna, Anna, McDowell, Andrew, Ruzicka, Filip, Smrcka, Martin, Jancalek, Radim, Maca, Karel, Lujc, Michael, Ahmed, Fahad S, Birkenmaier, Christof, Dudli, Stefan, Slaby, Ondrej

“…Previously, we proposed the hypothesis that similarities in the inflammatory response observed in acne vulgaris and degenerative disc disease (DDD), especially…”
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Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site by Banach, Bailey B., Pletnev, Sergei, Olia, Adam S., Xu, Kai, Zhang, Baoshan, Rawi, Reda, Bylund, Tatsiana, Doria-Rose, Nicole A., Nguyen, Thuy Duong, Fahad, Ahmed S., Lee, Myungjin, Lin, Bob C., Liu, Tracy, Louder, Mark K., Madan, Bharat, McKee, Krisha, O’Dell, Sijy, Sastry, Mallika, Schön, Arne, Bui, Natalie, Shen, Chen-Hsiang, Wolfe, Jacy R., Chuang, Gwo-Yu, Mascola, John R., Kwong, Peter D., DeKosky, Brandon J.

“…The HIV-1 fusion peptide (FP) represents a promising vaccine target, but global FP sequence diversity among circulating strains has limited anti-FP antibodies…”
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Mapping monoclonal anti-SARS-CoV-2 antibody repertoires against diverse coronavirus antigens by de Souza, Matheus Oliveira, Madan, Bharat, Teng, I-Ting, Huang, Aric, Liu, Lihong, Fahad, Ahmed S., Lopez Acevedo, Sheila N., Pan, Xiaoli, Sastry, Mallika, Gutierrez-Gonzalez, Matias, Yin, Michael T., Zhou, Tongqing, Ho, David D., Kwong, Peter D., DeKosky, Brandon J.

“…Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have emerged continuously, challenging the effectiveness of vaccines, diagnostics, and…”
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Is the "Common Cold" Our Greatest Ally in the Battle Against SARS-CoV-2? by Capoor, Manu N, Ahmed, Fahad S, McDowell, Andrew, Slaby, Ondrej

“…The discovery of T-cell responses to SARS-CoV-2 in non-infected individuals indicates cross-reactive immune memory from prior exposure to human coronaviruses…”
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Cell activation-based screening of natively paired human T cell receptor repertoires by Fahad, Ahmed S., Chung, Cheng Yu, López Acevedo, Sheila N., Boyle, Nicoleen, Madan, Bharat, Gutiérrez-González, Matías F., Matus-Nicodemos, Rodrigo, Laflin, Amy D., Ladi, Rukmini R., Zhou, John, Wolfe, Jacy, Llewellyn-Lacey, Sian, Koup, Richard A., Douek, Daniel C., Balfour, Henry H., Price, David A., DeKosky, Brandon J.

“…Adoptive immune therapies based on the transfer of antigen-specific T cells have been used successfully to treat various cancers and viral infections, but…”
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Large-scale antibody immune response mapping of splenic B cells and bone marrow plasma cells in a transgenic mouse model by Pan, Xiaoli, López Acevedo, Sheila N, Cuziol, Camille, De Tavernier, Evelyn, Fahad, Ahmed S, Longjam, Priyobarta S, Rao, Sambasiva P, Aguilera-Rodríguez, David, Rezé, Mathilde, Bricault, Christine A, Gutiérrez-González, Matías F, de Souza, Matheus Oliveira, DiNapoli, Joshua M, Vigne, Emmanuelle, Shahsavarian, Melody A, DeKosky, Brandon J

“…Molecular characterization of antibody immunity and human antibody discovery is mainly carried out using peripheral memory B cells, and occasionally…”
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Importance of Propionibacterium acnes hemolytic activity in human intervertebral discs: A microbiological study by Capoor, Manu N, Ruzicka, Filip, Sandhu, Gurpreet, Rollason, Jess, Mavrommatis, Konstantinos, Ahmed, Fahad S, Schmitz, Jonathan E, Raz, Assaf, Brüggemann, Holger, Lambert, Peter A, Fischetti, Vincent A, Slaby, Ondrej

“…Most patients with chronic lower back pain (CLBP) exhibit degenerative disc disease. Disc specimens obtained during initial therapeutic discectomies are often…”
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Prothrombin Time and Activated Partial Thromboplastin Time Testing: A Comparative Effectiveness Study in a Million-Patient Sample by Capoor, Manu N, Stonemetz, Jerry L, Baird, John C, Ahmed, Fahad S, Awan, Ahsan, Birkenmaier, Christof, Inchiosa, Jr, Mario A, Magid, Steven K, McGoldrick, Kathryn, Molmenti, Ernesto, Naqvi, Sajjad, Parker, Stephen D, Pothula, S M, Shander, Aryeh, Steen, R Grant, Urban, Michael K, Wall, Judith, Fischetti, Vincent A

“…A substantial fraction of all American healthcare expenditures are potentially wasted, and practices that are not evidence-based could contribute to such…”
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The achievement of non-high-density lipoprotein cholesterol target in patients with very high atherosclerotic cardiovascular disease risk stratified by triglyceride levels despite statin-controlled low-density lipoprotein cholesterol by Al-Sabti, Hilal, Al-Hinai, Ali T, Al-Zakwani, Ibrahim, Al-Hashmi, Khamis, Al Mahmeed, Wael, Arafah, Mohamed, Shehab, Abdullah, Al Tamimi, Omer, Al Awadhi, Mahmoud, Al Herz, Shorook, Al Anazi, Faisal, Al Nemer, Khalid, Metwally, Othman, Alkhadra, Akram, Fakhry, Mohammed, Elghetany, Hossam, Medani, Abdel Razak, Yusufali, Afzal Hussein, Al Jassim, Obaid, Al Hallaq, Omar, Baslaib, Fahad Omar Ahmed S, Amin, Haitham, Al-Waili, Khalid, Al-Rasadi, Khalid

“…The achievement of non-high-density lipoprotein cholesterol target in patients with very high atherosclerotic cardiovascular disease risk stratified by…”
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Strategies to Screen Anti-AQP4 Antibodies from Yeast Surface Display Libraries by Huang, Aric, Jin, Wei, Fahad, Ahmed S., Mussman, Brooklyn K., Nicchia, Grazia Paola, Madan, Bharat, de Souza, Matheus Oliveira, Griffin, J. Daniel, Bennett, Jeffrey L., Frigeri, Antonio, Berkland, Cory J., DeKosky, Brandon J.

“…A rapid and effective method to identify disease-specific antibodies from clinical patients is important for understanding autoimmune diseases and for the…”
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Sheep as a Potential Model of Intradiscal Infection by the Bacterium Cutibacterium acnes by Coscia, Erin C, Abutaleb, Nader S, Hostetter, Bradley, Seleem, Mohamed N, Breur, Gert J, McCain, Robyn R, Crain, Christa J, Slaby, Ondrej, Capoor, Manu N, McDowell, Andrew, Ahmed, Fahad S, Vijayanpillai, Viju, Narayanan, Sanjeev K, Coscia, Michael F

“…The anaerobic bacterium has been increasingly linked to the development of degenerative disc disease (DDD), although causality is yet to be conclusively…”
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Mapping the Future of Migration and Climate Change Science by Nawyn, Stephanie, He, Linlang, Chen, Jiquan, Axelrod, Mark, Irfan, Furqan, Ahmed, Fahad S., Walker, Mary Anne

“…The scholarship on migration and climate change has been rapidly developed over recent decades, moving away from apocalyptic predictions of mass displacement…”
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A review of microscopy-based evidence for the association of Propionibacterium acnes biofilms in degenerative disc disease and other diseased human tissue by Capoor, Manu N., Birkenmaier, Christof, Wang, Jeffrey C., McDowell, Andrew, Ahmed, Fahad S., Brüggemann, Holger, Coscia, Erin, Davies, David G., Ohrt-Nissen, Soren, Raz, Assaf, Ruzicka, Filip, Schmitz, Jonathan E., Fischetti, Vincent A., Slaby, Ondrej

“…Purpose Recent research shows an increasing recognition that organisms not traditionally considered infectious in nature contribute to disease processes…”
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Propionibacterium acnes biofilm is present in intervertebral discs of patients undergoing microdiscectomy by Capoor, Manu N, Ruzicka, Filip, Schmitz, Jonathan E, James, Garth A, Machackova, Tana, Jancalek, Radim, Smrcka, Martin, Lipina, Radim, Ahmed, Fahad S, Alamin, Todd F, Anand, Neel, Baird, John C, Bhatia, Nitin, Demir-Deviren, Sibel, Eastlack, Robert K, Fisher, Steve, Garfin, Steven R, Gogia, Jaspaul S, Gokaslan, Ziya L, Kuo, Calvin C, Lee, Yu-Po, Mavrommatis, Konstantinos, Michu, Elleni, Noskova, Hana, Raz, Assaf, Sana, Jiri, Shamie, A Nick, Stewart, Philip S, Stonemetz, Jerry L, Wang, Jeffrey C, Witham, Timothy F, Coscia, Michael F, Birkenmaier, Christof, Fischetti, Vincent A, Slaby, Ondrej

“…In previous studies, Propionibacterium acnes was cultured from intervertebral disc tissue of ~25% of patients undergoing microdiscectomy, suggesting a possible…”
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Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes by Zhou, Tongqing, Teng, I-Ting, Olia, Adam S., Cerutti, Gabriele, Gorman, Jason, Nazzari, Alexandra, Shi, Wei, Tsybovsky, Yaroslav, Wang, Lingshu, Wang, Shuishu, Zhang, Baoshan, Zhang, Yi, Katsamba, Phinikoula S., Petrova, Yuliya, Banach, Bailey B., Fahad, Ahmed S., Liu, Lihong, Lopez Acevedo, Sheila N., Madan, Bharat, Oliveira de Souza, Matheus, Pan, Xiaoli, Wang, Pengfei, Wolfe, Jacy R., Yin, Michael, Ho, David D., Phung, Emily, DiPiazza, Anthony, Chang, Lauren A., Abiona, Olubukola M., Corbett, Kizzmekia S., DeKosky, Brandon J., Graham, Barney S., Mascola, John R., Misasi, John, Ruckwardt, Tracy, Sullivan, Nancy J., Shapiro, Lawrence, Kwong, Peter D.

“…Biotin-labeled molecular probes, comprising specific regions of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike, would be helpful in the…”
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Highly protective antimalarial antibodies via precision library generation and yeast display screening by Banach, Bailey B, Tripathi, Prabhanshu, Da Silva Pereira, Lais, Gorman, Jason, Nguyen, Thuy Duong, Dillon, Marlon, Fahad, Ahmed S, Kiyuka, Patience K, Madan, Bharat, Wolfe, Jacy R, Bonilla, Brian, Flynn, Barbara, Francica, Joseph R, Hurlburt, Nicholas K, Kisalu, Neville K, Liu, Tracy, Ou, Li, Rawi, Reda, Schön, Arne, Shen, Chen-Hsiang, Teng, I-Ting, Zhang, Baoshan, Pancera, Marie, Idris, Azza H, Seder, Robert A, Kwong, Peter D, DeKosky, Brandon J

“…The monoclonal antibody CIS43 targets the Plasmodium falciparum circumsporozoite protein (PfCSP) and prevents malaria infection in humans for up to 9 mo…”
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Quality Control: Chain Pairing Precision and Monitoring of Cross-Sample Contamination: A Method by the AIRR Community by Chung, Cheng-Yu, Gutiérrez-González, Matías, López Acevedo, Sheila N, Fahad, Ahmed S, DeKosky, Brandon J

“…New approaches in high-throughput analysis of immune receptor repertoires are enabling major advances in immunology and for the discovery of precision…”
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Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody by Madan, Bharat, Zhang, Baoshan, Xu, Kai, Chao, Cara W., O’Dell, Sijy, Wolfe, Jacy R., Chuang, Gwo-Yu, Fahad, Ahmed S., Geng, Hui, Kong, Rui, Louder, Mark K., Nguyen, Thuy Duong, Rawi, Reda, Schön, Arne, Sheng, Zizhang, Nimrania, Rajani, Wang, Yiran, Zhou, Tongqing, Lin, Bob C., Doria-Rose, Nicole A., Shapiro, Lawrence, Kwong, Peter D., DeKosky, Brandon J.

“…Vaccine-based elicitation of broadly neutralizing antibodies holds great promise for preventing HIV-1 transmission. However, the key biophysical markers of…”
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