Search Results - "Fagone, Evelina"

Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: the role of class I P110 isoforms by Conte, Enrico, Fruciano, Mary, Fagone, Evelina, Gili, Elisa, Caraci, Filippo, Iemmolo, Maria, Crimi, Nunzio, Vancheri, Carlo

“…Idiopathic pulmonary fibrosis (IPF) is a progressive fibroproliferative disease characterized by an accumulation of fibroblasts and myofibroblasts in the…”
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Reactive oxygen species are required for maintenance and differentiation of primary lung fibroblasts in idiopathic pulmonary fibrosis by Bocchino, Marialuisa, Agnese, Savina, Fagone, Evelina, Svegliati, Silvia, Grieco, Domenico, Vancheri, Carlo, Gabrielli, Armando, Sanduzzi, Alessandro, Avvedimento, Enrico V

“…Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal illness whose pathogenesis remains poorly understood. Recent evidence suggests oxidative stress…”
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Reciprocal Interplay Between Astrocytes and CD4+ Cells Affects Blood-Brain Barrier and Neuronal Function in Response to β Amyloid by Spampinato, Simona Federica, Merlo, Sara, Fagone, Evelina, Fruciano, Mary, Sano, Yasuteru, Kanda, Takashi, Sortino, Maria Angela

“…Background: In Alzheimer’s disease (AD) neuronal degeneration is associated with gliosis and infiltration of peripheral blood mononuclear cells (PBMCs), which…”
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Astrocytes Modify Migration of PBMCs Induced by β-Amyloid in a Blood-Brain Barrier in vitro Model by Spampinato, Simona Federica, Merlo, Sara, Fagone, Evelina, Fruciano, Mary, Barbagallo, Cristina, Kanda, Takashi, Sano, Yasuteru, Purrello, Michele, Vancheri, Carlo, Ragusa, Marco, Sortino, Maria Angela

“…The brain is protected by the blood-brain barrier (BBB), constituted by endothelial cells supported by pericytes and astrocytes. In Alzheimer's disease a…”
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Clinical and Prognostic Significance of p-ANCA Positivity in Idiopathic Pulmonary Fibrosis: A Retrospective Observational Study by Libra, Alessandro, Muscato, Giuseppe, Ielo, Giuseppe, Spicuzza, Lucia, Palmucci, Stefano, Fagone, Evelina, Fruciano, Mary, Gili, Elisa, Sambataro, Gianluca, Vancheri, Carlo

“…Perinuclear Anti Neutrophil Cytoplasmic Antibody (p-ANCA) is a serological marker of Microscopic Polyangiitis (MPA), a vasculitis associated with lung…”
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Patients with Interstitial Lung Disease Secondary to Autoimmune Diseases: How to Recognize Them? by Sambataro, Domenico, Sambataro, Gianluca, Pignataro, Francesca, Zanframundo, Giovanni, Codullo, Veronica, Fagone, Evelina, Martorana, Emanuele, Ferro, Francesco, Orlandi, Martina, Del Papa, Nicoletta, Cavagna, Lorenzo, Malatino, Lorenzo, Colaci, Michele, Vancheri, Carlo

“…The diagnostic assessment of patients with Interstitial Lung Disease (ILD) can be challenging due to the large number of possible causes. Moreover, the…”
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Myositis-Specific and Myositis-Associated Antibodies in Fibromyalgia Patients: A Prospective Study by Sambataro, Gianluca, Orlandi, Martina, Fagone, Evelina, Fruciano, Mary, Gili, Elisa, Libra, Alessandro, Palmucci, Stefano, Vancheri, Carlo, Malatino, Lorenzo, Colaci, Michele, Sambataro, Domenico

“…Fibromyalgia (FM) is a common rheumatologic disorder characterised by widespread muscular pain. Myalgia is also a common clinical feature in Connective Tissue…”
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Nailfold Videocapillaroscopy is a Useful Tool to Recognize Definite Forms of Systemic Sclerosis and Idiopathic Inflammatory Myositis in Interstitial Lung Disease Patients by Sambataro, Domenico, Sambataro, Gianluca, Libra, Alessandro, Vignigni, Giovanna, Pino, Fabio, Fagone, Evelina, Fruciano, Mary, Gili, Elisa, Pignataro, Francesca, Del Papa, Nicoletta, Vancheri, Carlo

“…Nailfold videocapillaroscopy (NVC) is an easy tool used for the assessment of patients with Raynaud's phenomenon (RP) as possibly associated with systemic…”
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16,16-Dimethyl Prostaglandin E2 Efficacy on Prevention and Protection from Bleomycin-Induced Lung Injury and Fibrosis by Failla, Marco, Genovese, Tiziana, Mazzon, Emanuela, Fruciano, Mary, Fagone, Evelina, Gili, Elisa, Barera, Annalisa, La Rosa, Cristina, Conte, Enrico, Crimi, Nunzio, Cuzzocrea, Salvatore, Vancheri, Carlo

“…In this study, we evaluated the protective effect and therapeutic potential of the prostaglandin E(2) (PGE(2)) synthetic analog 16,16-dimethyl-PGE(2)…”
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The Arg/Arg polymorphism of the ADRB2 is associated with the severity of allergic asthma by Scichilone, Nicola, MD, Caponetto, Chiara, MD, Fagone, Evelina, PhD, Benfante, Alida, MD, Paternò, Alessandra, PhD, Heffler, Enrico, MD, Crimi, Nunzio, MD, Vancheri, Carlo, MD

“…Characteristic Mild/moderate Severe P value Sex: M/F 25/26 14/19  Age (y) 49 ± 11 50 ± 13 .89 BMI (kg/m2) 25.9 ± 3.3 28.2 ± 3.3 .23 Serum IgE (IU/mL) 257…”
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Effect of pirfenidone on proliferation, TGF-β-induced myofibroblast differentiation and fibrogenic activity of primary human lung fibroblasts by Conte, Enrico, Gili, Elisa, Fagone, Evelina, Fruciano, Mary, Iemmolo, Maria, Vancheri, Carlo

“…[Display omitted] Pirfenidone is an orally active small molecule that has been shown to inhibit the progression of fibrosis in animal models and in patients…”
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Anti-inflammatory and antifibrotic effects of resveratrol in the lung by Conte, Enrico, Fagone, Evelina, Fruciano, Mary, Gili, Elisa, Iemmolo, Maria, Vancheri, Carlo

“…Resveratrol, a natural polyphenolic molecule with several biological activities, is a well recognized anti-oxidant, anti-aging and cancer chemopreventive…”
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PI3K p110γ overexpression in idiopathic pulmonary fibrosis lung tissue and fibroblast cells: in vitro effects of its inhibition by Conte, Enrico, Gili, Elisa, Fruciano, Mary, Korfei, Martina, Fagone, Evelina, Iemmolo, Maria, Lo Furno, Debora, Giuffrida, Rosario, Crimi, Nunzio, Guenther, Andreas, Vancheri, Carlo

“…Idiopathic pulmonary fibrosis (IPF) is a progressive fibroproliferative disease whose molecular pathogenesis remains unclear. In a recent paper, we…”
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Circulating Coding and Long Non-Coding RNAs as Potential Biomarkers of Idiopathic Pulmonary Fibrosis by Di Mauro, Stefania, Scamporrino, Alessandra, Fruciano, Mary, Filippello, Agnese, Fagone, Evelina, Gili, Elisa, Scionti, Francesca, Purrazzo, Giacomo, Di Pino, Antonino, Scicali, Roberto, Di Martino, Maria Teresa, Malaguarnera, Roberta, Malatino, Lorenzo, Purrello, Francesco, Vancheri, Carlo, Piro, Salvatore

“…Idiopathic Pulmonary Fibrosis (IPF) is a chronic degenerative disease with a median survival of 2-5 years after diagnosis. Therefore, IPF patient…”
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Preventive and therapeutic effects of thymosin β4 N-terminal fragment Ac-SDKP in the bleomycin model of pulmonary fibrosis by Conte, Enrico, Fagone, Evelina, Gili, Elisa, Fruciano, Mary, Iemmolo, Maria, Pistorio, Maria Provvidenza, Impellizzeri, Daniela, Cordaro, Marika, Cuzzocrea, Salvatore, Vancheri, Carlo

“…In this study, the bleomycin model of pulmonary fibrosis was utilized to investigate putative anti-fibrotic activity of Ac-SDKP in vivo. Male CD-1 mice…”
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Thymosin beta 4 reduces IL-17-producing cells and IL-17 expression, and protects lungs from damage in bleomycin-treated mice by Conte, Enrico, Iemmolo, Maria, Fagone, Evelina, Gili, Elisa, Fruciano, Mary, Genovese, Tiziana, Esposito, Emanuela, Cuzzocrea, Salvatore, Vancheri, Carlo

“…Thymosin beta 4 (T beta 4) is a highly conserved peptide with immunomodulatory properties. In this research we investigated the effects of T beta 4 on the…”
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Effects of thymosin β4 and its N-terminal fragment Ac-SDKP on TGF-β-treated human lung fibroblasts and in the mouse model of bleomycin-induced lung fibrosis by Conte, Enrico, Iemmolo, Maria, Fruciano, Mary, Fagone, Evelina, Gili, Elisa, Genovese, Tiziana, Esposito, Emanuela, Cuzzocrea, Salvatore, Vancheri, Carlo

“…Thymosin β4 (Tβ4) and its amino-terminal fragment comprising N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) have been reported to act as anti-inflammatory and…”
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Type 2-High Severe Asthma with and without Bronchiectasis: A Prospective Observational Multicentre Study by Crimi, Claudia, Campisi, Raffaele, Nolasco, Santi, Ferri, Sebastian, Cacopardo, Giulia, Impellizzeri, Pietro, Pistorio, Maria Provvidenza, Fagone, Evelina, Pelaia, Corrado, Heffler, Enrico, Crimi, Nunzio

“…Type 2-high severe asthma (T2-SA) is often associated with several comorbidities. To this extent, the coexistence of T2-SA and bronchiectasis (BE) is…”
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Human lung fibroblasts increase CD4(+)CD25(+)Foxp3(+) T cells in co-cultured CD4(+) lymphocytes by Conte, Enrico, Gili, Elisa, Fruciano, Mary, Fagone, Evelina, Vancheri, Carlo

“…•Lung fibroblasts induce an expansion of CD4+CD25+FoxP3+ regulatory T cells in vitro.•PGE2 secreted by fibroblasts is responsible for this phenomenon.•Expanded…”
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Thymosin β4 protects C57BL/6 mice from bleomycin-induced damage in the lung by Conte, Enrico, Genovese, Tiziana, Gili, Elisa, Esposito, Emanuela, Iemmolo, Maria, Fruciano, Mary, Fagone, Evelina, Pistorio, Maria P., Crimi, Nunzio, Cuzzocrea, Salvatore, Vancheri, Carlo

“…Background Thymosin β4 (Tβ4) was recently found at high concentration in the bronchoalveolar lavage fluid (BALF) of scleroderma patients with lung involvement…”
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