Search Results - "Fagni, Laurent"

GPCR Interacting Proteins (GIPs) in the Nervous System: Roles in Physiology and Pathologies by BOCKAERT, Joël, PERROY, Julie, BECAMEL, Carine, MARIN, Philippe, FAGNI, Laurent

“…G protein-coupled receptors (GPCRs) are key transmembrane recognition molecules for regulatory signals such as light, odors, taste hormones, and…”
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mGlu1 receptor canonical signaling pathway contributes to the opening of the orphan GluD2 receptor by Dadak, Selma, Bouquier, Nathalie, Goyet, Elise, Fagni, Laurent, Levenes, Carole, Perroy, Julie

“…The orphan Glutamate receptor Delta2 (GluD2) intrinsic ion channel activity is indirectly triggered by glutamate through stimulation of the metabotropic…”
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Extracellular Interactions between GluR2 and N-Cadherin in Spine Regulation by Saglietti, Laura, Dequidt, Caroline, Kamieniarz, Kinga, Rousset, Marie-Claude, Valnegri, Pamela, Thoumine, Olivier, Beretta, Francesca, Fagni, Laurent, Choquet, Daniel, Sala, Carlo, Sheng, Morgan, Passafaro, Maria

“…Via its extracellular N-terminal domain (NTD), the AMPA receptor subunit GluR2 promotes the formation and growth of dendritic spines in cultured hippocampal…”
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The mGlu7 receptor provides protective effects against epileptogenesis and epileptic seizures by Girard, Benoit, Tuduri, Pola, Moreno, Maria Paula, Sakkaki, Sophie, Barboux, Cedric, Bouschet, Tristan, Varrault, Annie, Vitre, Jihane, McCort-Tranchepain, Isabelle, Dairou, Julien, Acher, Francine, Fagni, Laurent, Marchi, Nicola, Perroy, Julie, Bertaso, Federica

“…Finding new targets to control or reduce seizure activity is essential to improve the management of epileptic patients. We hypothesized that activation of the…”
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Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons by Bertaso, Federica, Roussignol, Gautier, Worley, Paul, Bockaert, Joël, Fagni, Laurent, Ango, Fabrice

“…A large number of evidences suggest that group-I metabotropic glutamate receptors (mGluR1a, 1b, 1c, 5a, 5b) can modulate NMDA receptor activity. Interestingly,…”
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The RhoGEF DOCK10 is essential for dendritic spine morphogenesis by Jaudon, Fanny, Raynaud, Fabrice, Wehrlé, Rosine, Bellanger, Jean-Michel, Doulazmi, Mohamed, Vodjdani, Guilan, Gasman, Stéphane, Fagni, Laurent, Dusart, Isabelle, Debant, Anne, Schmidt, Susanne

“…By regulating actin cytoskeleton dynamics, Rho GTPases and their activators RhoGEFs are implicated in various aspects of neuronal differentiation, including…”
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Shank Expression Is Sufficient to Induce Functional Dendritic Spine Synapses in Aspiny Neurons by Roussignol, Gautier, Ango, Fabrice, Romorini, Stefano, Tu, Jian Cheng, Sala, Carlo, Worley, Paul F, Bockaert, Joel, Fagni, Laurent

“…Shank proteins assemble glutamate receptors with their intracellular signaling apparatus and cytoskeleton at the postsynaptic density. Whether Shank plays a…”
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Direct Interaction Enables Cross-talk between Ionotropic and Group I Metabotropic Glutamate Receptors by Perroy, Julie, Raynaud, Fabrice, Homburger, Vincent, Rousset, Marie-Claude, Telley, Ludovic, Bockaert, Joël, Fagni, Laurent

“…Functional interplay between ionotropic and metabotropic receptors frequently involves complex intracellular signaling cascades. The group I metabotropic…”
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Dynamic remodeling of scaffold interactions in dendritic spines controls synaptic excitability by Moutin, Enora, Raynaud, Fabrice, Roger, Jonathan, Pellegrino, Emilie, Homburger, Vincent, Bertaso, Federica, Ollendorff, Vincent, Bockaert, Joël, Fagni, Laurent, Perroy, Julie

“…Scaffolding proteins interact with membrane receptors to control signaling pathways and cellular functions. However, the dynamics and specific roles of…”
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Key Role of the Postsynaptic Density Scaffold Proteins Shank and Homer in the Functional Architecture of Ca2+ Homeostasis at Dendritic Spines in Hippocampal Neurons by Sala, Carlo, Roussignol, Gautier, Meldolesi, Jacopo, Fagni, Laurent

“…A key aspect of postsynaptic function, also important for plasticity, is the segregation within dendritic spines of Ca2+ rises attributable to release from…”
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The ‘magic tail’ of G protein-coupled receptors: an anchorage for functional protein networks by Bockaert, Joël, Marin, Philippe, Dumuis, Aline, Fagni, Laurent

“…All cell types express a great variety of G protein-coupled receptors (GPCRs) that are coupled to only a limited set of G proteins. This disposition favors…”
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Gelatinase Biosensor Reports Cellular Remodeling During Epileptogenesis by Bouquier, Nathalie, Girard, Benoit, Aparicio Arias, Juri, Fagni, Laurent, Bertaso, Federica, Perroy, Julie

“…Epileptogenesis is the gradual process responsible for converting a healthy brain into an epileptic brain. This process can be triggered by a wide range of…”
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GKAP-DLC2 interaction organizes the postsynaptic scaffold complex to enhance synaptic NMDA receptor activity by Moutin, Enora, Raynaud, Fabrice, Fagni, Laurent, Perroy, Julie

“…At glutamatergic brain synapses, scaffolding proteins regulate receptor location and function. The targeting and organization of scaffolding proteins in the…”
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Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus by Dinamarca, Margarita C, Guzzetti, Francesca, Karpova, Anna, Lim, Dmitry, Mitro, Nico, Musardo, Stefano, Mellone, Manuela, Marcello, Elena, Stanic, Jennifer, Samaddar, Tanmoy, Burguière, Adeline, Caldarelli, Antonio, Genazzani, Armando A, Perroy, Julie, Fagni, Laurent, Canonico, Pier Luigi, Kreutz, Michael R, Gardoni, Fabrizio, Di Luca, Monica

“…Synapses and nuclei are connected by bidirectional communication mechanisms that enable information transfer encoded by macromolecules. Here, we identified…”
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Distinct subsynaptic localization of type 1 metabotropic glutamate receptors at glutamatergic and GABAergic synapses in the rodent cerebellar cortex by Mansouri, Mahnaz, Kasugai, Yu, Fukazawa, Yugo, Bertaso, Federica, Raynaud, Fabrice, Perroy, Julie, Fagni, Laurent, Kaufmann, Walter A., Watanabe, Masahiko, Shigemoto, Ryuichi, Ferraguti, Francesco

“…Type 1 metabotropic glutamate (mGlu1) receptors play a pivotal role in different forms of synaptic plasticity in the cerebellar cortex, e.g. long‐term…”
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Loss of X-Linked Mental Retardation Gene Oligophrenin1 in Mice Impairs Spatial Memory and Leads to Ventricular Enlargement and Dendritic Spine Immaturity by Khelfaoui, Malik, Denis, Cecile, van Galen, Elly, de Bock, Frederic, Schmitt, Alain, Houbron, Christophe, Morice, Elise, Giros, Bruno, Ramakers, Ger, Fagni, Laurent, Chelly, Jamel, Nosten-Bertrand, Marika, Billuart, Pierre

“…Loss of oligophrenin1 (OPHN1) function in human causes X-linked mental retardation associated with cerebellar hypoplasia and, in some cases, with lateral…”
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PICK1 uncoupling from mGluR7a causes absence-like seizures by Bockaert, Joël, Bertaso, Federica, Zhang, Chuansheng, Scheschonka, Astrid, de Bock, Frédéric, Fontanaud, Pierre, Marin, Philippe, Huganir, Richard L, Betz, Heinrich, Fagni, Laurent, Lerner-Natoli, Mireille

“…Mice lacking the metabotropic glutamate receptor mGluR7 are hypersensitive to convulsant drugs. But how does mGluR7 act to prevent seizures? Here the authors…”
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Epac mediates PACAP-dependent long-term depression in the hippocampus by Ster, Jeanne, De Bock, Frédéric, Bertaso, Federica, Abitbol, Karine, Daniel, Hervé, Bockaert, Joël, Fagni, Laurent

“…Extensive work has shown that activation of the cAMP-dependent protein kinase A (PKA) is crucial for long-term depression (LTD) of synaptic transmission in the…”
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RNAi silencing of P/Q-type calcium channels in Purkinje neurons of adult mouse leads to episodic ataxia type 2 by Salvi, Julie, Bertaso, Federica, Mausset-Bonnefont, Anne-Laure, Metz, Alexandra, Lemmers, Céline, Ango, Fabrice, Fagni, Laurent, Lory, Philippe, Mezghrani, Alexandre

“…Abstract Episodic ataxia type-2 (EA2) is a dominantly inherited human neurological disorder caused by loss of function mutations in the CACNA1A gene, which…”
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Complex interactions between mGluRs, intracellular Ca2+ stores and ion channels in neurons by FAGNI, L, CHAVIS, P, ANGO, F, BOCKAERT, J

“…Metabotropic glutamate receptors (mGluRs) can increase intracellular Ca2+ concentration via Ins(1,4,5)P3- and ryanodine-sensitive Ca2+ stores in neurons. Both…”
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