Relation between systemic inflammatory markers, peripheral muscle mass, and strength in limb muscles in stable COPD patients

The aim of this study was to investigate the association between systemic inflammatory mediators and peripheral muscle mass and strength in COPD patients. Fifty-five patients (69% male; age: 64±9 years) with mild/very severe COPD (defined as forced expiratory volume in the first second [FEV1] =54%±2...

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Bibliographic Details
Published in:	International journal of chronic obstructive pulmonary disease Vol. 10; no. Issue 1; pp. 1553 - 1558
Main Authors:	Ferrari, Renata, Caram, Laura M O, Faganello, Marcia M, Sanchez, Fernanda F, Tanni, Suzana E, Godoy, Irma
Format:	Journal Article
Language:	English
Published:	New Zealand Dove Medical Press Limited 01-01-2015 Dove Medical Press Ltd Dove Medical Press
Subjects:	Aged Airway management Biomarkers - blood Body mass index C-Reactive Protein - analysis Chronic illnesses Chronic obstructive lung disease Chronic obstructive pulmonary disease Complications and side effects Development and progression Dyspnea Female Forced Expiratory Volume Humans Inflammation Inflammation Mediators - blood Lung - physiopathology Lung diseases Male Medical research Middle Aged Muscle Strength Muscle Weakness - blood Muscle Weakness - diagnosis Muscle Weakness - etiology Muscle Weakness - physiopathology Muscle, Skeletal - diagnostic imaging Muscle, Skeletal - physiopathology Nutritional Status Organ Size Original Research Physiological aspects Plasma Pulmonary Disease, Chronic Obstructive - blood Pulmonary Disease, Chronic Obstructive - complications Pulmonary Disease, Chronic Obstructive - diagnosis Pulmonary Disease, Chronic Obstructive - physiopathology Quadriceps Muscle - physiopathology Regression analysis Risk factors Sarcopenia - blood Sarcopenia - diagnosis Sarcopenia - etiology Sarcopenia - physiopathology Severity of Illness Index Spirometry Tomography, X-Ray Computed Tumor Necrosis Factor-alpha - blood Vital Capacity Weightlifting Brazil United States > US skeletal muscle Inflammation X-Ray Computed Tomography
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Summary:	The aim of this study was to investigate the association between systemic inflammatory mediators and peripheral muscle mass and strength in COPD patients. Fifty-five patients (69% male; age: 64±9 years) with mild/very severe COPD (defined as forced expiratory volume in the first second [FEV1] =54%±23%) were evaluated. We evaluated serum concentrations of IL-8, CRP, and TNF-α. Peripheral muscle mass was evaluated by computerized tomography (CT); midthigh cross-sectional muscle area (MTCSA) and midarm cross-sectional muscle area (MACSA) were obtained. Quadriceps, triceps, and biceps strength were assessed through the determination of the one-repetition maximum. The multiple regression results, adjusted for age, sex, and FEV1%, showed positive significant association between MTCSA and leg extension (0.35 [0.16, 0.55]; P=0.001), between MACSA and triceps pulley (0.45 [0.31, 0.58]; P=0.001), and between MACSA and biceps curl (0.34 [0.22, 0.47]; P=0.001). Plasma TNF-α was negatively associated with leg extension (-3.09 [-5.99, -0.18]; P=0.04) and triceps pulley (-1.31 [-2.35, -0.28]; P=0.01), while plasma CRP presented negative association with biceps curl (-0.06 [-0.11, -0.01]; P=0.02). Our results showed negative association between peripheral muscle mass (evaluated by CT) and muscle strength and that systemic inflammation has a negative influence in the strength of specific groups of muscles in individuals with stable COPD. This is the first study showing association between systemic inflammatory markers and strength in upper limb muscles.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1178-2005 1176-9106 1178-2005
DOI:	10.2147/copd.s85954