Search Results - "Fadzen, Colin M"

Blood–brain-barrier organoids for investigating the permeability of CNS therapeutics by Bergmann, Sonja, Lawler, Sean E., Qu, Yuan, Fadzen, Colin M., Wolfe, Justin M., Regan, Michael S., Pentelute, Bradley L., Agar, Nathalie Y. R., Cho, Choi-Fong

“…In vitro models of the blood–brain barrier (BBB) are critical tools for the study of BBB transport and the development of drugs that can reach the CNS. Brain…”
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Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents by Cho, Choi-Fong, Wolfe, Justin M., Fadzen, Colin M., Calligaris, David, Hornburg, Kalvis, Chiocca, E. Antonio, Agar, Nathalie Y. R., Pentelute, Bradley L., Lawler, Sean E.

“…Culture-based blood–brain barrier (BBB) models are crucial tools to enable rapid screening of brain-penetrating drugs. However, reproducibility of in vitro…”
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Perfluoroaryl Bicyclic Cell‐Penetrating Peptides for Delivery of Antisense Oligonucleotides by Wolfe, Justin M., Fadzen, Colin M., Holden, Rebecca L., Yao, Monica, Hanson, Gunnar J., Pentelute, Bradley L.

“…Exon‐skipping antisense oligonucleotides are effective treatments for genetic diseases, yet exon‐skipping activity requires that these macromolecules reach the…”
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CT and MRI features differentiating mucinous cystic neoplasms of the liver from pathologically simple cysts by Anderson, Mark A., Dhami, Ranjodh S., Fadzen, Colin M., Molina, George, Taylor, Martin S., Deshpande, Vikram, Qadan, Motaz, Catalano, Onofrio A., Ferrone, Cristina R., Mojtahed, Amirkasra

“…The purpose of this study was to determine if CT and MRI features can accurately differentiate mucinous cystic neoplasms (MCNs) from simple liver cysts and to…”
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Machine Learning To Predict Cell-Penetrating Peptides for Antisense Delivery by Wolfe, Justin M., Fadzen, Colin M., Choo, Zi-Ning, Holden, Rebecca L., Yao, Monica, Hanson, Gunnar J., Pentelute, Bradley L.

“…Cell-penetrating peptides (CPPs) can facilitate the intracellular delivery of large therapeutically relevant molecules, including proteins and…”
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Targeting Glioblastoma Using a Novel Peptide Specific to a Deglycosylated Isoform of Brevican by Spreckelsen, Niklas, Fadzen, Colin M., Hartrampf, Nina, Ghotmi, Yarah, Wolfe, Justin M., Dubey, Shipra, Yang, Bo Yeun, Kijewski, Marie F., Wang, Shuyan, Farquhar, Charlotte, Bergmann, Sonja, Zdioruk, Mykola, Wasserburg, J. Roscoe, Scott, Benjamin, Murrell, Emily, Bononi, Fernanda C., Luyt, Leonard G., DiCarli, Marcelo, Lamfers, Martine L. M., Ligon, Keith L., Chiocca, E. Antonio, Viapiano, Mariano S., Pentelute, Bradley L., Lawler, Sean E., Cho, Choi‐Fong

“…Glioblastoma (GBM) is the most common and deadliest form of brain tumor and remains amongst the most difficult cancers to treat. Brevican (Bcan), a central…”
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Perfluoroarene–Based Peptide Macrocycles to Enhance Penetration Across the Blood–Brain Barrier by Fadzen, Colin M, Wolfe, Justin M, Cho, Choi-Fong, Chiocca, E. Antonio, Lawler, Sean E, Pentelute, Bradley L

“…Here we describe the utility of peptide macrocyclization through perfluoroaryl-cysteine SNAr chemistry to improve the ability of peptides to cross the…”
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Labeling proteins with fluorophore/thioamide Förster resonant energy transfer pairs by combining unnatural amino acid mutagenesis and native chemical ligation by Wissner, Rebecca F, Batjargal, Solongo, Fadzen, Colin M, Petersson, E James

“…We have recently shown that p-cyanophenylalanine (Cnf) and a thioamide can be used as a minimally perturbing Förster resonant energy transfer (FRET) pair to…”
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A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins by Cohen, Daniel T., Zhang, Chi, Fadzen, Colin M., Mijalis, Alexander J., Hie, Liana, Johnson, Kenneth D., Shriver, Zachary, Plante, Obadiah, Miller, Scott J., Buchwald, Stephen L., Pentelute, Bradley L.

“…Conjugates between proteins and small molecules enable access to a vast chemical space that is not achievable with either type of molecule alone; however, the…”
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Deep learning to design nuclear-targeting abiotic miniproteins by Schissel, Carly K., Mohapatra, Somesh, Wolfe, Justin M., Fadzen, Colin M., Bellovoda, Kamela, Wu, Chia-Ling, Wood, Jenna A., Malmberg, Annika B., Loas, Andrei, Gómez-Bombarelli, Rafael, Pentelute, Bradley L.

“…There are more amino acid permutations within a 40-residue sequence than atoms on Earth. This vast chemical search space hinders the use of human learning to…”
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A Platinum(IV) ProdrugPerfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain by Fadzen, Colin M, Wolfe, Justin M, Zhou, Wen, Cho, Choi-Fong, von Spreckelsen, Niklas, Hutchinson, Kathryn T, Lee, Yen-Chun, Chiocca, E. Antonio, Lawler, Sean E, Yilmaz, Omer H, Lippard, Stephen J, Pentelute, Bradley L

“…Effective delivery to the brain limits the development of novel glioblastoma therapies. Here, we introduce conjugation between platinum­(IV) prodrugs of…”
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Chimeras of Cell-Penetrating Peptides Demonstrate Synergistic Improvement in Antisense Efficacy by Fadzen, Colin M, Holden, Rebecca L, Wolfe, Justin M, Choo, Zi-Ning, Schissel, Carly K, Yao, Monica, Hanson, Gunnar J, Pentelute, Bradley L

“…Phosphorodiamidate morpholino oligonucleotides (PMOs) make up a promising class of therapeutics for genetic disease. PMOs designed for “exon skipping” must be…”
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A Tumor-Homing Peptide Platform Enhances Drug Solubility, Improves Blood-Brain Barrier Permeability and Targets Glioblastoma by Cho, Choi-Fong, Farquhar, Charlotte E, Fadzen, Colin M, Scott, Benjamin, Zhuang, Pei, von Spreckelsen, Niklas, Loas, Andrei, Hartrampf, Nina, Pentelute, Bradley L, Lawler, Sean E

“…Glioblastoma (GBM) is the most common and deadliest malignant primary brain tumor, contributing significant morbidity and mortality among patients. As current…”
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Perfluoroaryl Bicyclic Cell‐Penetrating Peptides for Delivery of Antisense Oligonucleotides by Wolfe, Justin M., Fadzen, Colin M., Holden, Rebecca L., Yao, Monica, Hanson, Gunnar J., Pentelute, Bradley L.

“…Exon‐skipping antisense oligonucleotides are effective treatments for genetic diseases, yet exon‐skipping activity requires that these macromolecules reach the…”
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Serum Tumor Markers Lack Predictive Value for Benign Intrahepatic Cysts by Fadzen, Colin M., Molina, George, Qadan, Motaz, Taylor, Martin S, Deshpande, Vikram, Catalano, Onofrio, Tanabe, Kenneth K., Berger, David L., Ferrone, Cristina R.

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Labeling Proteins with Fluorophore/Thioamide FRET Pairs by Combining Unnatural Amino Acid Mutagenesis and Native Chemical Ligation by Wissner, Rebecca F., Batjargal, Solongo, Fadzen, Colin M., Petersson, E. James

“…We have recently shown that p -cyanophenylalanine (Cnf) and a thioamide can be used as a minimally-perturbing Förster resonant energy transfer (FRET) pair to…”
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Labeling Proteins with Fluorophore/Thioamide Förster Resonant Energy Transfer Pairs by Combining Unnatural Amino Acid Mutagenesis and Native Chemical Ligation by Wissner, Rebecca F, Batjargal, Solongo, Fadzen, Colin M, Petersson, E. James

“…We have recently shown that p-cyanophenylalanine (Cnf) and a thioamide can be used as a minimally perturbing Förster resonant energy transfer (FRET) pair to…”
Get full text