Search Results - "Fadul, Motaz M."

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain by Fadul, Motaz M, Garwood, Claire J, Waller, Rachel, Garrett, Navonna, Heath, Paul R, Matthews, Fiona E, Brayne, Carol, Wharton, Stephen B, Simpson, Julie E

“…Astrocytes play a major role in the pathogenesis of a range of neurodegenerative diseases, including Alzheimer's disease (AD), undergoing dramatic…”
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Transcriptomic Analysis of Age-Associated Periventricular Lesions Reveals Dysregulation of the Immune Response by Fadul, Motaz M, Heath, Paul R, Cooper-Knock, Johnathan, Kurz, Julian M, Al-Azzawi, Hayder A, Ali, Zarki, Smith, Taylor, Matthews, Fiona E, Brayne, Carol, Wharton, Stephen B, Simpson, Julie E

“…White matter lesions (WML) are a common feature of the ageing brain associated with cognitive impairment. The gene expression profiles of periventricular…”
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The effect of chemotherapies on the crosstalk interaction between CD8 cytotoxic T-cells and MHC-I peptides in the microenvironment of WHO grade 4 astrocytoma by Butt, Nadeem, Enani, Maryam, Alshanqiti, Maryam, Alkhotani, Alaa, Alsinani, Taghreed, Karami, Mohammed Matoog, Fadul, Motaz M, Almansouri, Majid, Hassan, Amber, Baeesa, Saleh, Bamaga, Ahmed K, Alkhayyat, Shadi, Faizo, Eyad, Kurdi, Maher

“…Introduction: CD8+ T-cells and MHC-I have been detected in brain gliomas with a significant outcome. The effect of chemotherapies on the crosstalk interaction…”
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The synergistic effect of IDH mutation and NDRG-2 dysregulation in the progression of WHO-grade 4 astrocytomas by Kurdi, Maher, Fadul, Motaz M, Alkhayyat, Shadi, Sabbagh, Abdulrahman J, Alsinani, Taghreed, Alkhotani, Alaa, Mulla, Nasser, Mehboob, Riffat, Fathaddin, Amany A, Bamaga, Ahmed, Faizo, Eyad, Baeesa, Saleh

“…NDRG2 is a tumour suppressor gene involved in tumor growth inhibition. Its effect on tumour recurrence remains controversial. The aim of this study is to…”
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Dynamic interplay between corticosteroid treatment and the role of SRC-1 gene dysregulation in the progression of WHO-Grade 4 Astrocytoma by Kurdi, Maher, Fadul, Motaz M, Addas, Bassam M. J., Faizo, Eyad, Alkhayyat, Shadi, Bamaga, Ahmed K., Alsinani, Taghreed, Katib, Yousef, Okal, Fahad, Maghrabi, Yazid, Sabbagh, Abdulrahman J., Moshref, Rana, Albalawi, Sultan, Alkhotani, Alaa, Halawa, Taher F., Mulla, Nasser, Hakamy, Sahar, Baeesa, Saleh

“…Background Corticosteroid is commonly used before surgery to control cerebral oedema in brain tumours and is frequently continued throughout treatment. Its…”
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Immune microenvironment of medulloblastoma: The association between its molecular subgroups and potential targeted immunotherapeutic receptors by Kurdi, Maher, Mulla, Nasser, Malibary, Husam, Bamaga, Ahmed K, Fadul, Motaz M, Faizo, Eyad, Hakamy, Sahar, Baeesa, Saleh

“…Medulloblastoma (MB) is considered the commonest malignant brain tumor in children. Multimodal treatments consisting of surgery, radiation, and chemotherapy…”
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The effect of p53 on the activity of NRF2 and NDRG2 genes through apoptotic pathway in IDH-wildtype glioblastoma by Kurdi, Maher, Baeesa, Saleh, Fadul, Motaz M., Alkhotani, Alaa, Alkhayyat, Shadi, Karami, Mohammed M., Alsinani, Taghreed, Katib, Yousef, Fathaddin, Amany A., Faizo, Eyad, Lary, Ahmed I., Almansouri, Majid, Maghrabi, Yazid, Alyousef, Mohammed A., Addass, Bassam

“…Tumor suppressor (p53) acts to integrate multiple stress signals into diverse antiproliferative responses. Its potential to transactivate or downregulate genes…”
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Major Histocompatibility Class-I (MHC-I) downregulation in glioblastoma is a poor prognostic factor but not a predictive indicator for treatment failure by Butt, Nadeem S., Kurdi, Maher, Fadul, Motaz M., Hakamy, Sahar, Addas, Bassam M.J., Faizo, Eyad, Alkhayyat, Shadi, Bamaga, Ahmed K., Alsinani, Taghreed, Katib, Yousef, Okal, Fahad, Maghrabi, Yazid, Sabbagh, Abdulrahman J., Moshref, Rana, Albalawi, Sultan, Alkhotani, Alaa, Mohammed, Fawaz, Mulla, Nasser, Baeesa, Saleh

“…BACKGROUNDMHC-I expression is a crucial factor in cancer immunity, and its regulations can impact tumor progression and recurrence. The mechanism through which…”
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Glioblastoma with PRMT5 gene upregulation is a key target for tumor cell regression by Kurdi, Maher, Fadul, Motaz M., Addas, Bassam, Faizo, Eyad, Bamaga, Ahmed K., Alsinani, Taghreed, Katib, Yousef, Alkhotani, Alaa, Fathaddin, Amany A., Turkistani, Alaa N., Najjar, Ahmed A., Baeesa, Saleh, Toonsi, Fadi A., Almansouri, Majid, Alkhayyat, Shadi

“…Abstract Objectives Protein Arginine Methyltransferase 5 ( PRMT5 ) is an enzyme that regulates gene expression and protein function through arginine…”
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The association between NRF2 transcriptional gene dysregulation and IDH mutation in Grade 4 astrocytoma by Kurdi, Maher, Fadul, Motaz M., Addas, Bassam J., Faizo, Eyad, Alkhayyat, Shadi, Okal, Fahad, Alkhotani, Alaa, Sabbagh, Abdulrahman J., Abutalib, Mohammed, Bamaga, Ahmed K., Fathaddin, Amany A., Baeesa, Saleh

“…Abstract Objectives Nuclear factor erythroid-2-related factor 2 (NRF2), a transcriptional gene factor related to nuclear factor erythroid 2, plays a role in…”
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The Role of Liquid Biopsy in the Diagnosis and Prognosis of WHO Grade 4 Astrocytoma by Halawa, Taher, Baeesa, Saleh, Fadul, Motaz M, Badahdah, Adnan A, Enani, Maryam, Fathaddin, Amany A, Kawass, Dania, Alkhotani, Alaa, Bahakeem, Basem, Kurdi, Maher

“…Liquid biopsy, as a non-invasive diagnostic tool, has recently gained significant attention in the field of oncology. It involves the analysis of various…”
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