Heteroresistance to Fluconazol in Clinical and Environmental Brazilian Strains of Cryptococcus neoformans/C. gattii Species Complex

Heteroresistance to Fluconazol in Clinical and Environmental Brazilian Strains of Cryptococcus neoformans/C. gattii Species Complex

Purpose of Study To review the literature on heteroresistance to fluconazole (FLC) and investigate the level of heteroresistance to FLC (LHF), we analyzed 100 clinical and environmental Brazilian Cryptococcus strains. Recent Findings Heteroresistance is a phenomenon described as the emergence of res...

Full description

Saved in:
Bibliographic Details
Published in:Current fungal infection reports Vol. 11; no. 4; pp. 190 - 196
Main Authors: Feliciano, L. M., Ramos, S. D. P., Szeszs, M. W., Martins, M. A., Bonfietti, L. X., Oliveira, R. A., Santos, D. C. S., Fadul, L. H., Silva, D. F., Paula, C. R., Trilles, L., Silva, L. E. A., Ferreira-Paim, K., Mora, D. J., Andrade, A. A., Silva, P. R., Silva-Vergara, M. L., Roberto, T. N., Melhem, M. S. C.
Format: Journal Article
Language:English
Published: New York Springer US 01-12-2017
Springer Nature B.V
Subjects:
Clinical Mycology Lab Issues (S Córdoba
Fluconazole
Infectious Diseases
Internal Medicine
Medicine
Medicine & Public Health
Minimum inhibitory concentration
Occupational Medicine/Industrial Medicine
Pneumology/Respiratory System
Section Editor
Species
Topical Collection on Clinical Mycology Lab Issues
Tropical Medicine
Heteroresistance
Fluconazole
Antifungal resistance
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose of Study To review the literature on heteroresistance to fluconazole (FLC) and investigate the level of heteroresistance to FLC (LHF), we analyzed 100 clinical and environmental Brazilian Cryptococcus strains. Recent Findings Heteroresistance is a phenomenon described as the emergence of resistant subpopulation cells within a single susceptible strain that can tolerate higher concentrations of fluconazole above the minimal inhibitory concentration (MIC) level. Summary We found lower FLC-MICs (0.12–64 mg/L) than LHF (8–128 mg/L). Highly heteroresistant adapted subpopulations (256 mg/L) was found in minority (9%) strains, but importantly, 33% showed low FLC-MIC (8 mg/L). We concluded for similar LHF in both species, but higher LHF in clinical strains in comparison to environmental ones. Our findings stressed that the LHF is not correlated to species and pretty is strain-dependent and alert about high heteroresistant subpopulations that hardly reverts to the original LHF even upon the removal of drug pressure.
ISSN:1936-3761
1936-377X
DOI:10.1007/s12281-017-0298-1