Antioxidant and the ameliorating effect of Allium cepa (Onion) fortified feed against potassium bromate induced oxidative damage in Wistar rats

•Allium cepa fortified feed protected against oxidative damage by potassium bromate.•Malondialdehyde (MDA) levels in the hepato-renal declined significantly in rat fed fortified feed.•Histo-architectural of hepato-renal cells were restored to near normal following the administration of fortified fee...

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Published in:	Toxicology reports Vol. 8; pp. 759 - 766
Main Authors:	Nwonuma, C.O., Osemwegie, O.O., Alejolowo, O.O., Irokanulo, E.O., Olaniran, A.F., Fadugba, D.O., Opaleke, D.O., Ojo, O.A.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier B.V 01-01-2021 Elsevier
Subjects:	Allium cepa Antioxidant Fortification Haematology Histopathology Potassium bromate Regular Allium cepa Histopathology Haematology Antioxidant Fortification Potassium bromate
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Summary:	•Allium cepa fortified feed protected against oxidative damage by potassium bromate.•Malondialdehyde (MDA) levels in the hepato-renal declined significantly in rat fed fortified feed.•Histo-architectural of hepato-renal cells were restored to near normal following the administration of fortified feed. Allium cepa Linn (Onion) Organosulfuric compounds and phytonutrients have medicinal benefits. The study estimated the antioxidant effect of Allium cepa in fortified feed against oxidative damage caused by potassium bromate. Commercial feed was fortified by substituting 10 %, 20 %, and 30 % of rat's daily ration with the respective portion of pulverized Allium cepa. Potassium bromate was administered orally to the rats in all the groups except rats in the normal control. The rats in the test groups were allowed access to the fortified feed ad libitum. The animals were sacrificed; consequently, the serum, liver, and kidney were obtained for biochemical assay and histological assessment. The percentage composition of some amino acids and some proximate were higher in the fortified feed. Furthermore, Malondialdehyde (MDA) level in the liver, kidney, and serum decreased significantly (P ≤ 0.05) in rats fed with fortified feed compared to administered only Potassium bromate. Similarly, the concentration of total protein increased significantly (P ≤ 0.05) in the liver, kidney, and serum of the animals fed with fortified feed. The hematology result was normal in rats fed with fortified feed. The liver and kidney cell architecture was normal in animals fed with fortified feed. Allium cepa may have conferred protection and amelioration to oxidative damage by potassium bromate in rats.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2214-7500 2214-7500
DOI:	10.1016/j.toxrep.2021.03.029