Search Results - "Fadok, V A"

Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release by Monks, J, Rosner, D, Geske, F Jon, Lehman, L, Hanson, L, Neville, M C, Fadok, V A

“…Clearance of apoptotic cells is critical to tissue homeostasis and resolution of inflammatory lesions. Macrophages are known to remove dying cells and release…”
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A receptor for phosphatidylserine-specific clearance of apoptotic cells by Fadok, Valerie A, Bratton, Donna L, Rose, David M, Pearson, Alan, Ezekewitz, R. Alan B, Henson, Peter M

“…The culmination of apoptosis in vivo is phagocytosis of cellular corpses. During apoptosis, the asymmetry of plasma membrane phospholipids is lost, which…”
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If phosphatidylserine is the death knell, a new phosphatidylserine-specific receptor is the bellringer by Fadok, V A, Xue, D, Henson, P

“…Recognition of phosphatidylserine (PtdSer) is essential for engulfment of apoptotic cells by mammalian phagocytes. Engagement of a new…”
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Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages by Fadok, VA, Voelker, DR, Campbell, PA, Cohen, JJ, Bratton, DL, Henson, PM

“…During normal tissue remodeling, macrophages remove unwanted cells, including those that have undergone programmed cell death, or apoptosis. This widespread…”
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Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells by Fadok, VA, Savill, JS, Haslett, C, Bratton, DL, Doherty, DE, Campbell, PA, Henson, PM

“…One of the key features associated with programmed cell death in many tissues is the phagocytosis of apoptotic bodies by macrophages. Removal of apoptotic…”
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Equine allergic skin diseases: Clinical consensus guidelines of the World Association for Veterinary Dermatology by Marsella, R., White, S., Fadok, V. A., Wilson, D., Mueller, R., Outerbridge, C., Rosenkrantz, W.

“…Background Allergic skin diseases are common in horses worldwide. The most common causes are insect bites and environmental allergens. Objectives To review the…”
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Regulation of macrophage cytokine production by phagocytosis of apoptotic and post-apoptotic cells by Fadok, V A, McDonald, P P, Bratton, D L, Henson, P M

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Particle digestibility is required for induction of the phosphatidylserine recognition mechanism used by murine macrophages to phagocytose apoptotic cells by Fadok, VA, Laszlo, DJ, Noble, PW, Weinstein, L, Riches, DW, Henson, PM

“…One of the characteristic features of programmed cell death in vivo is the rapid recognition and removal of apoptotic cells by macrophages. Although there are…”
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Apoptotic cell removal by Henson, Peter M, Bratton, Donna L, Fadok, Valerie A

“…Ingestion by professional or amateur phagocytes is the fate of most cells that undergo apoptosis. Studies in both Caenorhabditis elegans and mammals are now…”
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Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences by Fadok, V A, Bratton, D L, Henson, P M

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C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells by Ogden, C A, deCathelineau, A, Hoffmann, P R, Bratton, D, Ghebrehiwet, B, Fadok, V A, Henson, P M

“…Removal of apoptotic cells is essential for maintenance of tissue homeostasis, organogenesis, remodeling, development, and maintenance of the immune system,…”
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Aberrant Wound Healing and TGF-β Production in the Autoimmune-Prone MRL/+ Mouse by Kench, Jennifer A., Russell, David M., Fadok, Valerie A., Young, Scott K., Worthen, G.Scott, Jones-Carson, Jessica, Henson, Janet E., Henson, Peter M., Nemazee, David

“…Wound healing is a complex process that involves inflammation, apoptosis, growth, and tissue remodeling. The autoimmune-prone inbred mouse strain MRL/+…”
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Loss of Phospholipid Asymmetry and Surface Exposure of Phosphatidylserine Is Required for Phagocytosis of Apoptotic Cells by Macrophages and Fibroblasts by Fadok, Valerie A., de Cathelineau, Aimee, Daleke, David L., Henson, Peter M., Bratton, Donna L.

“…Removal of apoptotic cells during tissue remodeling or resolution of inflammation is critical to the restoration of normal tissue structure and function…”
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Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF by Fadok, V A, Bratton, D L, Konowal, A, Freed, P W, Westcott, J Y, Henson, P M

“…Apoptosis in vivo is followed almost inevitably by rapid uptake into adjacent phagocytic cells, a critical process in tissue remodeling, regulation of the…”
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The phosphatidylserine receptor: a crucial molecular switch? by Henson, Peter M, Bratton, Donna L, Fadok, Valerie A

“…The uptake and removal of necrotic or lysed cells involves inflammation and an immune response, due in part to processes that involve members of the collectin…”
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Phosphatidylserine (PS) Induces PS Receptor-Mediated Macropinocytosis and Promotes Clearance of Apoptotic Cells by Hoffmann, Peter R., deCathelineau, Aimee M., Ogden, Carol Anne, Leverrier, Yann, Bratton, Donna L., Daleke, David L., Ridley, Anne J., Fadok, Valerie A., Henson, Peter M.

“…Efficient phagocytosis of apoptotic cells is important for normal tissue development, homeostasis, and the resolution of inflammation. Although many receptors…”
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A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo by Taylor, P R, Carugati, A, Fadok, V A, Cook, H T, Andrews, M, Carroll, M C, Savill, J S, Henson, P M, Botto, M, Walport, M J

“…The strongest susceptibility genes for the development of systemic lupus erythematosus (SLE) in humans are null mutants of classical pathway complement…”
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Differential Effects of Apoptotic Versus Lysed Cells on Macrophage Production of Cytokines: Role of Proteases by Fadok, Valerie A, Bratton, Donna L, Guthrie, Lindsay, Henson, Peter M

“…Granulocytes undergoing apoptosis are recognized and removed by phagocytes before their lysis. The release of their formidable arsenal of proteases and other…”
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The role of phosphatidylserine in recognition of apoptotic cells by phagocytes by Fadok, V A, Bratton, D L, Frasch, S C, Warner, M L, Henson, P M

“…Exposure of phosphatidylserine on the outer leaflet of the plasma membrane is a surface change common to many apoptotic cells. Normally restricted to the inner…”
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The phagocytosis of apoptotic cells by Fadok, Valerie A, Chimini, Giovanna

“…Apoptosis is a genetically controlled event taking care of cell turnover in healthy adult tissues and of focal elimination of cells during embryonic…”
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