Search Results - "Fadl, Samar"

Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2 by Ferreira, Juliana C., Fadl, Samar, Rabeh, Wael M.

“…3C-like protease (3CLpro) processes and liberates functional viral proteins essential for the maturation and infectivity of severe acute respiratory syndrome…”
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Catalytic Dyad Residues His41 and Cys145 Impact the Catalytic Activity and Overall Conformational Fold of the Main SARS-CoV-2 Protease 3-Chymotrypsin-Like Protease by Ferreira, Juliana C., Fadl, Samar, Villanueva, Adrian J., Rabeh, Wael M.

“…Coronaviruses are responsible for multiple pandemics and millions of deaths globally, including the current pandemic of coronavirus disease 2019 (COVID-19)…”
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AFM-compatible microfluidic platform for affinity-based capture and nanomechanical characterization of circulating tumor cells by Deliorman, Muhammedin, Janahi, Farhad K., Sukumar, Pavithra, Glia, Ayoub, Alnemari, Roaa, Fadl, Samar, Chen, Weiqiang, Qasaimeh, Mohammad A.

“…Circulating tumor cells (CTCs) carried by the patient’s bloodstream are known to lead to the metastatic spread of cancer. It is becoming increasingly clear…”
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Ribokinase and fructokinase: function–structure relationship by Ferreira, Juliana C., Fadl, Samar, Rabeh, Wael M.

“…Abstract only…”
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pH profiles of 3-chymotrypsin-like protease (3CLpro) from SARS-CoV-2 elucidate its catalytic mechanism and a histidine residue critical for activity by Al Adem, Kenana, Ferreira, Juliana C., Fadl, Samar, Rabeh, Wael M.

“…3-Chymotrypsin-like protease (3CLpro) is a promising drug target for coronavirus disease 2019 and related coronavirus diseases because of the essential role of…”
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Dimethyl sulfoxide reduces the stability but enhances catalytic activity of the main SARS‐CoV‐2 protease 3CLpro by Ferreira, Juliana C., Fadl, Samar, Ilter, Metehan, Pekel, Hanife, Rezgui, Rachid, Sensoy, Ozge, Rabeh, Wael M.

“…Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is responsible for coronavirus disease 2019 (COVID‐19), one of the most challenging global…”
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Identification of novel allosteric sites of SARS-CoV-2 papain-like protease (PLpro) for the development of COVID-19 antivirals by Ferreira, Juliana C., Villanueva, Adrian J., Al Adem, Kenana, Fadl, Samar, Alzyoud, Lara, Ghattas, Mohammad A., Rabeh, Wael M.

“…Coronaviruses such as SARS-CoV-2 encode a conserved papain-like protease (PLpro) that is crucial for viral replication and immune evasion, making it a prime…”
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Residues in the fructose-binding pocket are required for ketohexokinase-A activity by Ferreira, Juliana C., Villanueva, Adrian J., Fadl, Samar, Al Adem, Kenana, Cinviz, Zeynep Nur, Nedyalkova, Lyudmila, Cardoso, Thyago H.S., Andrade, Mario Edson, Saksena, Nitin K., Sensoy, Ozge, Rabeh, Wael M.

“…Excessive fructose consumption is a primary contributor to the global surges in obesity, cancer, and metabolic syndrome. Fructolysis is not robustly regulated…”
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3-chymotrypsin-like protease in SARS-CoV-2 by Al Adem, Kenana, Ferreira, Juliana C, Villanueva, Adrian J, Fadl, Samar, El-Sadaany, Farah, Masmoudi, Imen, Gidiya, Yugmee, Gurudza, Tariro, Cardoso, Thyago H S, Saksena, Nitin K, Rabeh, Wael M

“…Coronaviruses constitute a significant threat to the human population. Severe acute respiratory syndrome coronavirus-2, SARS-CoV-2, is a highly pathogenic…”
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Boosting immunity: synergistic antiviral effects of luteolin, vitamin C, magnesium and zinc against SARS-CoV-2 3CLpro by Ferreira, Juliana C, Fadl, Samar, Cardoso, Thyago H S, Andrade, Bruno Silva, Melo, Tarcisio S, Silva, Edson Mario de Andrade, Agarwal, Anupriya, Turville, Stuart J, Saksena, Nitin K, Rabeh, Wael M

“…SARS-CoV-2 was first discovered in 2019 and has disseminated throughout the globe to pandemic levels, imposing significant health and economic burdens…”
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