Search Results - "Faden, A I"

Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death by Liu, S, Sarkar, C, Dinizo, M, Faden, A I, Koh, E Y, Lipinski, M M, Wu, J

“…Autophagy is a catabolic mechanism facilitating degradation of cytoplasmic proteins and organelles in a lysosome-dependent manner. Autophagy flux is necessary…”
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Anandamide-induced cell death in primary neuronal cultures: role of calpain and caspase pathways by Movsesyan, V A, Stoica, B A, Yakovlev, A G, Knoblach, S M, Lea, 4th, P M, Cernak, I, Vink, R, Faden, A I

“…Anandamide (arachidonoylethanolamide or AEA) is an endocannabinoid that acts at vanilloid (VR1) as well as at cannabinoid (CB1/CB2) and NMDA receptors. Here,…”
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Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia by Bao, W.L, Williams, A.J, Faden, A.I, Tortella, F.C

“…Activation of group I metabotropic glutamate receptors (mGluR) has been implicated in the pathophysiology of acute central nervous system injury. However, the…”
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miR-711 upregulation induces neuronal cell death after traumatic brain injury by Sabirzhanov, B, Stoica, B A, Zhao, Z, Loane, D J, Wu, J, Dorsey, S G, Faden, A I

“…Traumatic brain injury (TBI) is a leading cause of mortality and disability. MicroRNAs (miRs) are small noncoding RNAs that negatively regulate gene expression…”
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Downregulation of miR-23a and miR-27a following experimental traumatic brain injury induces neuronal cell death through activation of proapoptotic Bcl-2 proteins by Sabirzhanov, Boris, Zhao, Zaorui, Stoica, Bogdan A, Loane, David J, Wu, Junfang, Borroto, Carlos, Dorsey, Susan G, Faden, Alan I

“…MicroRNAs (miRs) are small noncoding RNAs that negatively regulate gene expression at the post-transcriptional level. To identify miRs that may regulate…”
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Administration of either anti-intercellular adhesion molecule-1 or a nonspecific control antibody improves recovery after traumatic brain injury in the rat by Knoblach, S M, Faden, A I

“…Intercellular adhesion molecule-1 (ICAM-1) is an endothelial protein that facilitates invasion of leukocytes into the CNS in response to injury or…”
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Pharmacological strategies in CNS trauma by Faden, A I, Salzman, S

“…Delayed biochemical changes play an important role in tissue damage resulting from traumatic injuries to the central nervous system. Identification of such…”
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Sustained sensory/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouse by Fox, G B, Fan, L, Levasseur, R A, Faden, A I

“…A mouse model of traumatic brain injury was developed using a device that produces controlled cortical impact (CCI), permitting independent manipulation of…”
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TrkB.T1 contributes to neuropathic pain after spinal cord injury through regulation of cell cycle pathways by Wu, Junfang, Renn, Cynthia L, Faden, Alan I, Dorsey, Susan G

“…Spinal cord injury (SCI) frequently causes severe, persistent central neuropathic pain that responds poorly to conventional pain treatments. Brain-derived…”
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Combined mechanical trauma and metabolic impairment in vitro induces NMDA receptor‐dependent neuronal cell death and caspase‐3‐dependent apoptosis by Allen, J. W., Knoblach, S. M., Faden, A. I.

“…ABSTRACTNeuronal necrosis and apoptosis occur after traumatic brain injury (TBI) in animals and contribute to subsequent neurological deficits. In contrast,…”
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Activation of CPP32-Like Caspases Contributes to Neuronal Apoptosis and Neurological Dysfunction after Traumatic Brain Injury by Yakovlev, Alexander G, Knoblach, Susan M, Fan, Lei, Fox, Gerard B, Goodnight, Randyll, Faden, Alan I

“…We examined the temporal profile of apoptosis after fluid percussion-induced traumatic brain injury (TBI) in rats and investigated the potential…”
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Selective caspase activation may contribute to neurological dysfunction after experimental spinal cord trauma by Knoblach, S.M., Huang, X., VanGelderen, J., Calva-Cerqueira, D., Faden, A.I.

“…Caspases are implicated in apoptotic cell death after spinal cord injury (SCI), but the relative contribution of these proteases to the secondary injury…”
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Endogenous Repair after Spinal Cord Contusion Injuries in the Rat by Beattie, M.S., Bresnahan, J.C., Komon, J., Tovar, C.A., Van Meter, M., Anderson, D.K., Faden, A.I., Hsu, C.Y., Noble, L.J., Salzman, S., Young, W.

“…Contusion injuries of the rat thoracic spinal cord were made using a standardized device developed for the Multicenter Animal Spinal Cord Injury Study…”
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Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury by Byrnes, Kimberly R., Stoica, Bogdan A., Fricke, Stanley, Di Giovanni, Simone, Faden, Alan I.

“…Spinal cord injury (SCI) causes delayed secondary biochemical alterations that lead to tissue loss and associated neurological dysfunction. Up-regulation of…”
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Diffusion and High Resolution MRI of Traumatic Brain Injury in Rats: Time Course and Correlation with Histology by Albensi, Benedict C., Knoblach, Susan M., Chew, Benjamin G.M., O'Reilly, Michael P., Faden, Alan I., Pekar, James J.

“…Although widely employed in studies of cerebral ischemia, the use of diffusion-weighted imaging (DWI) for traumatic brain injury (TBI) has been both limited…”
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Dynorphin increases extracellular levels of excitatory amino acids in the brain through a non-opioid mechanism by Faden, AI

“…Administration of dynorphin A-(1-17) (Dyn 1-17), through a microdialysis probe stereotaxically placed into rat hippocampus, caused marked increases in the…”
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β-Amyloid-induced apoptosis of cerebellar granule cells and cortical neurons: exacerbation by selective inhibition of group I metabotropic glutamate receptors by Allen, J.W, Eldadah, B.A, Faden, A.I

“…Administration of β-amyloid fragment 25–35 (Aβ 25–35) to cultured rat cerebellar granule cells (CGC) or cortical neurons caused cell death that was…”
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New in vitro model of traumatic neuronal injury: evaluation of secondary injury and glutamate receptor-mediated neurotoxicity by Mukhin, A G, Ivanova, S A, Knoblach, S M, Faden, A I

“…The multiplicity and complexity of secondary injury processes following brain trauma in vivo make it difficult to elucidate the roles of specific injury…”
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Consistent and reproducible slice selection in rodent brain using a novel stereotaxic device for MRI by Fricke, S.T, Vink, R, Chiodo, C, Cernak, I, Ileva, L, Faden, A.I

“…Typically small animal radiological images are obtained after placing the animal in the center of the imaging device using beds or platforms, and then…”
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Behavioral responses of C57BL/6, FVB/N, and 129/SvEMS mouse strains to traumatic brain injury: implications for gene targeting approaches to neurotrauma by Fox, G B, LeVasseur, R A, Faden, A I

“…Recent studies have suggested that mouse models of traumatic brain injury may be useful for evaluating the role of single gene products in brain trauma. In the…”
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