Search Results - "Fadayel, Gina M."

Effects of season stratum corneum barrier function and skin biomarkers by Wei, Karl Shiqing, Stella, Ching, Wehmeyer, Kenneth R, Christman, Jeremy, Altemeier, Amy, Spruell, Russell, Wimalasena, Rohan L, Fadayel, Gina M, Reilman, Raymond A, Motlagh, Safa, Stoffolano, Peter J, Benzing, Kathleen, Wickett, R Randall

“…The skin on the lower legs of 25 female subjects was evaluated first in the winter, and then again in the summer of the same subjects. Barrier function was…”
Get more information

Discovery and in vitro/in vivo studies of tetrazole derivatives as Kv1.5 blockers by Wu, Shengde, Fluxe, Andrew, Sheffer, Jim, Janusz, John M., Blass, Benjamin E., White, Ron, Jackson, Chris, Hedges, Richard, Murawsky, Michael, Fang, Bin, Fadayel, Gina M., Hare, Michelle, Djandjighian, Laurent

“…A novel class of tetrazole-derived Kv1.5 blockers is disclosed. In in vitro studies, several compounds had IC 50 ranging from 180 to 550 nM. In vivo studies…”
Get full text

Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist by Baron, Bruce M, Harrison, Boyd L, Kehne, John H, Schmidt, Christopher J, Van Giersbergen, Paul L.M, White, H.Steven, Siegel, Barry W, Senyah, Yaw, McCloskey, Timothy C, Fadayel, Gina M, Taylor, Vicki L, Murawsky, Michael K, Nyce, Phillip, Salituro, Francesco G

“…MDL 105,519, ( E)-3-(2-phenyl-2-carboxyethenyl)-4,6-dichloro-1 H-indole-2-carboxylic acid, is a potent and selective inhibitor of [ 3H]glycine binding to the…”
Get full text

Discovery and synthesis of tetrahydroindolone derived semicarbazones as selective Kv1.5 blockers by Wu, Shengde, Fluxe, Andrew, Janusz, John M., Sheffer, James B., Browning, Greg, Blass, Benjamin, Cobum, Keith, Hedges, Richard, Murawsky, Michael, Fang, Bin, Fadayel, Gina M., Hare, Michelle, Djandjighian, Laurent

“…A novel class of tetrahydroindolone-derived semicarbazones has been discovered as potent Kv1.5 blockers. In in vitro studies, several compounds exhibited very…”
Get full text

Synthesis and evaluation of (2-phenethyl-2 H-1,2,3-triazol-4-yl)(phenyl)methanones as Kv1.5 channel blockers for the treatment of atrial fibrillation by Blass, Benjamin E., Coburn, Keith, Lee, Wenlin, Fairweather, Neil, Fluxe, Andrew, Wu, Shengde, Janusz, John M., Murawsky, Michael, Fadayel, Gina M., Fang, Bin, Hare, Michelle, Ridgeway, Jim, White, Ron, Jackson, Chris, Djandjighian, Laurent, Hedges, Richard, Wireko, Fred C., Ritter, Amanda L.

“…A series of novel (2-phenethyl-2 H-1,2,3-triazol-4-yl)(phenyl)methanones were prepared and examined for utility as Kv1.5 channel blockers for the treatment of…”
Get full text

Discovery and synthesis of tetrahydroindolone-derived carbamates as Kv1.5 blockers by Fluxe, Andrew, Wu, Shengde, Sheffer, James B., Janusz, John M., Murawsky, Michael, Fadayel, Gina M., Fang, Bin, Hare, Michelle, Djandjighian, Laurent

“…A novel class of tetrahydroindolone-derived carbamates has been discovered whose members are potent Kv1.5 blockers. The in vitro data show that compounds 6 and…”
Get full text

The selective 5-HT2A receptor antagonist, MDL 100,907, increases dopamine efflux in the prefrontal cortex of the rat by Schmidt, C J, Fadayel, G M

“…Diminished function within the mesocortical dopamine system has been to hypothesized to contribute directly to the negative and indirectly to the positive…”
Get full text

Regional effects of MK-801 on dopamine release: effects of competitive NMDA or 5-HT2A receptor blockade by Schmidt, C J, Fadayel, G M

“…The open channel N-methyl-D-aspartate (NMDA) receptor antagonists dizocilpine (MK-801) and phencyclidine (PCP) increase the firing rate of both A9 and A10…”
Get more information

5-HT2 receptors exert a state-dependent regulation of dopaminergic function: studies with MDL 100,907 and the amphetamine analogue, 3,4-methylenedioxymethamphetamine by Schmidt, C J, Fadayel, G M, Sullivan, C K, Taylor, V L

“…The highly selective 5-HT2 receptor antagonist, MDL 100,907, was used to explore the role of serotonin in the stimulation of dopaminergic function produced by…”
Get more information

The selective 5-HT 2A receptor antagonist, MDL 100,907, increases dopamine efflux in the prefrontal cortex of the rat by Schmidt, Christopher J., Fadayel, Gina M.

“…Diminished function within the mesocortical dopamine system has been to hypothesized to contribute directly to the negative and indirectly to the positive…”
Get full text

5-HT2A receptor-mediated regulation of cortical and subcortical dopaminergic systems: Studies with the selective antagonist, MDL 100 907 by Schmidt, Christopher J., Fadayel, Gina M., Ring, Sharon C., Taylor, Vicki L.

Get full text

5-HT 2A receptor-mediated regulation of cortical and subcortical dopaminergic systems: Studies with the selective antagonist, MDL 100 907 by Schmidt, Christopher J., Fadayel, Gina M., Ring, Sharon C., Taylor, Vicki L.

Get full text

The 5-HT2 receptor antagonist, MDL 28,133A, disrupts the serotonergic-dopaminergic interaction mediating the neurochemical effects of 3,4-methylenedioxymethamphetamine by Schmidt, C J, Black, C K, Taylor, V L, Fadayel, G M, Humphreys, T M, Nieduzak, T R, Sorensen, S M

“…The selective 5-HT2 receptor antagonist MDL 28,133A dose dependently-blocked the long-term deficits in rat brain 5-HT concentrations produced by the…”
Get more information

Analysis of ( R)-4-oxo-5-phosphononorvaline (MDL 100,453) in rat plasma and brain dialysate using liquid chromatography after derivatization with 6-aminoquinolyl- N-hydroxysuccinimidyl carbamate by Cornelius, Kenneth E., Fadayel, Gina M., Baron, Bruce M., Schmidt, Christopher J., Haegele, Klaus D., Chen, Teng-Man

“…A liquid chromatographic (LC) method with precolumn derivatization and fluorescence detection has been developed for the quantitation of (…”
Get full text