Macrophage-Mediated Inflammation in Skin Wound Healing

Macrophage-Mediated Inflammation in Skin Wound Healing

Macrophages are key immune cells that respond to infections, and modulate pathophysiological conditions such as wound healing. By possessing phagocytic activities and through the secretion of cytokines and growth factors, macrophages are pivotal orchestrators of inflammation, fibrosis, and wound rep...

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Bibliographic Details
Published in:Cells (Basel, Switzerland) Vol. 11; no. 19; p. 2953
Main Authors: Hassanshahi, Alireza, Moradzad, Mohammad, Ghalamkari, Saman, Fadaei, Moosa, Cowin, Allison J, Hassanshahi, Mohammadhossein
Format: Journal Article
Language:English
Published: Basel MDPI AG 21-09-2022
MDPI
Subjects:
Angiogenesis
Bone marrow
Care and treatment
Cell cycle
Cytokines
Dendritic cells
Diabetes
Epigenetics
Fibrosis
Genotype & phenotype
Growth factors
Health aspects
Inflammation
Macrophages
Metabolism
Methods
Neutrophils
Phagocytes
Phenotypes
Proteins
Review
Skin
Wound healing
Australia
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Summary:Macrophages are key immune cells that respond to infections, and modulate pathophysiological conditions such as wound healing. By possessing phagocytic activities and through the secretion of cytokines and growth factors, macrophages are pivotal orchestrators of inflammation, fibrosis, and wound repair. Macrophages orchestrate the process of wound healing through the transitioning from predominantly pro-inflammatory (M1-like phenotypes), which present early post-injury, to anti-inflammatory (M2-like phenotypes), which appear later to modulate skin repair and wound closure. In this review, different cellular and molecular aspects of macrophage-mediated skin wound healing are discussed, alongside important aspects such as macrophage subtypes, metabolism, plasticity, and epigenetics. We also highlight previous studies demonstrating interactions between macrophages and these factors for optimal wound healing. Understanding and harnessing the activity and capability of macrophages may help to advance new approaches for improving healing of the skin.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2073-4409
2073-4409
DOI:10.3390/cells11192953