Effects of early palliative care integration on patients with newly diagnosed multiple myeloma

Effects of early palliative care integration on patients with newly diagnosed multiple myeloma

Purpose While numerous studies underscore the benefits of early palliative care (EPC) for patients with solid tumors, its effects on patients with multiple myeloma (MM) are not as widely known. This study aims to determine the effects of EPC integration on patients with newly diagnosed symptomatic M...

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Bibliographic Details
Published in:Supportive care in cancer Vol. 32; no. 7; p. 468
Main Authors: Samala, Renato V., Nurse, Daniel P., Chen, Xiaoying, Wei, Wei, Crook, Jasmine J., Fada, Sherry D., Valent, Jason
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01-07-2024
Springer Nature B.V
Subjects:
Adult
Aged
Anxiety - etiology
Clinical outcomes
Cohort Studies
Depression - etiology
Female
Humans
Male
Medical diagnosis
Medicine
Medicine & Public Health
Middle Aged
Multiple myeloma
Multiple Myeloma - psychology
Multiple Myeloma - therapy
Nursing
Nursing Research
Oncology
Pain
Pain Medicine
Palliative care
Palliative Care - methods
Patient care planning
Prospective Studies
Quality of Life
Rehabilitation Medicine
Palliative care
Early palliative care
Palliative medicine
Symptomatic multiple myeloma
Multiple myeloma
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Summary:Purpose While numerous studies underscore the benefits of early palliative care (EPC) for patients with solid tumors, its effects on patients with multiple myeloma (MM) are not as widely known. This study aims to determine the effects of EPC integration on patients with newly diagnosed symptomatic MM and the feasibility of this approach. Methods This prospective cohort study enrolled patients within eight weeks of diagnosis. Participants met with a palliative care team monthly for 12 months. Functional Assessment of Cancer Therapy-General (FACT-G) plus Multiple Myeloma Subscale (FACT-MM), and Hospital Anxiety and Depression Scale (HADS) were administered upon enrollment and every three months. Proportion of completed visits and assessments determined the feasibility of EPC. Results Of the twenty participants enrolled from January 2020 to November 2022, median age was 65 (range 40, 77), 15 (75%) were female, 15 (75%) were white, 65% completed assessments at six months, and 60% at 12 months. The following measures significantly improved at 12 months versus baseline: FACT-G scores increased by 15.1 points (adjusted 95% CI: 2.2–28.1, adjusted p  = 0.02); Functional Well-Being scores increased by 6.0 points (adjusted 95% CI: 1.1–10.9, adjusted p  = 0.01); and Pain Subscale scores increased by 3.4 points (adjusted 95% CI: 0.5–6.4, adjusted p  = 0.02). Depression and anxiety scores did not significantly change over time. Conclusion Functional well-being, pain experience and overall QOL improved in a cohort of patients with newly diagnosed MM after 12 months of EPC involvement. Although monthly visits seemed feasible, the findings suggest that further research is needed to explore the optimal timing of palliative care interventions in the MM trajectory. Trial registration ClinicalTrials.gov ID NCT04248244 (Registration Date: January 30, 2020).
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ISSN:0941-4355
1433-7339
1433-7339
DOI:10.1007/s00520-024-08665-2