Search Results - "Facista, Salvatore"

PepSeq: a fully in vitro platform for highly multiplexed serology using customizable DNA-barcoded peptide libraries by Henson, Sierra N., Elko, Evan A., Swiderski, Piotr M., Liang, Yong, Engelbrektson, Anna L., Piña, Alejandra, Boyle, Annalee S., Fink, Zane, Facista, Salvatore J., Martinez, Vidal, Rahee, Fatima, Brown, Annabelle, Kelley, Erin J., Nelson, Georgia A., Raspet, Isaiah, Mead, Heather L., Altin, John A., Ladner, Jason T.

“…PepSeq is an in vitro platform for building and conducting highly multiplexed proteomic assays against customizable targets by using DNA-barcoded peptides…”
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Author Correction: PepSeq: a fully in vitro platform for highly multiplexed serology using customizable DNA-barcoded peptide libraries by Henson, Sierra N., Elko, Evan A., Swiderski, Piotr M., Liang, Yong, Engelbrektson, Anna L., Piña, Alejandra, Boyle, Annalee S., Fink, Zane, Facista, Salvatore J., Martinez, Vidal, Rahee, Fatima, Brown, Annabelle, Kelley, Erin J., Nelson, Georgia A., Raspet, Isaiah, Mead, Heather L., Altin, John A., Ladner, Jason T.

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Genomic landscapes of canine splenic angiosarcoma (hemangiosarcoma) contain extensive heterogeneity within and between patients by Wong, Shukmei, Ehrhart, E. J, Stewart, Samuel, Zismann, Victoria, Cawley, Jacob, Halperin, Rebecca, Briones, Natalia, Richter, Keith, Sivaprakasam, Karthigayini, Perdigones, Nieves, Contente-Cuomo, Tania, Facista, Salvatore, Trent, Jeffrey M, Murtaza, Muhammed, Khanna, Chand, Hendricks, William P. D

“…Cancer genomic heterogeneity presents significant challenges for understanding oncogenic processes and for cancer’s clinical management. Variation in driver…”
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Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2 by Gardner, Heather L., Sivaprakasam, Karthigayini, Briones, Natalia, Zismann, Victoria, Perdigones, Nieves, Drenner, Kevin, Facista, Salvatore, Richholt, Ryan, Liang, Winnie, Aldrich, Jessica, Trent, Jeffrey M., Shields, Peter G., Robinson, Nicholas, Johnson, Jeremy, Lana, Susan, Houghton, Peter, Fenger, Joelle, Lorch, Gwendolen, Janeway, Katherine A., London, Cheryl A., Hendricks, William P. D.

“…Osteosarcoma (OS) is a rare, metastatic, human adolescent cancer that also occurs in pet dogs. To define the genomic underpinnings of canine OS, we performed…”
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Local production of lactate, ribose phosphate, and amino acids within human triple-negative breast cancer by Ghergurovich, Jonathan M, Lang, Jessica D, Levin, Maren K, Briones, Natalia, Facista, Salvatore J, Mueller, Claudius, Cowan, Alexis J, McBride, Matthew J, Rodriguez, Esther San Roman, Killian, Aaron, Dao, Tuoc, Lamont, Jeffrey, Barron, Alison, Su, Xiaoyang, Hendricks, William P D, Espina, Virginia, Von Hoff, Daniel D, O'Shaughnessy, Joyce, Rabinowitz, Joshua D

“…Upregulated glucose metabolism is a common feature of tumors. Glucose can be broken down by either glycolysis or the oxidative pentose phosphate pathway…”
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Genomic tumor analysis provides clinical guidance for the management of diagnostically challenging cancers in dogs by Chon, Esther, Wang, Guannan, Whitley, Derick, Sakthikumar, Sharadha, Warrier, Manisha, Wong, Shukmei, Duran, Natalie, Adkins, Jonathan, Boateng, Martin, Zhu, Zhanyang, Facista, Salvatore, Haworth, David, Hendricks, William

“…To evaluate the diagnostic, prognostic, and therapeutic utility of a cancer genomic diagnostic assay (SearchLight DNA; Vidium Animal Health) for diagnostically…”
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Abstract 3412: Genomic signature of trastuzumab neoadjuvant therapy predictive of patient survival in HER2-positive breast cancer by Briones, Natalia, Facista, Salvatore, Halperin, Rebecca, Heaton, Paul, Mahadevan, Daruka, Hendricks, Wiiliam, Kim, Suwon

“…Abstract Although the adjuvant use of trastuzumab has significantly improved survival, therapy resistance still plagues HER2-positive breast cancer patients. A…”
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Genomic landscapes of canine splenic angiosarcoma by Wong, Shukmei, Ehrhart, E. J, Stewart, Samuel, Zismann, Victoria, Cawley, Jacob, Halperin, Rebecca, Briones, Natalia, Richter, Keith, Sivaprakasam, Karthigayini, Perdigones, Nieves, Contente-Cuomo, Tania, Facista, Salvatore, Trent, Jeffrey M, Murtaza, Muhammed, Khanna, Chand, Hendricks, William P. D

“…Cancer genomic heterogeneity presents significant challenges for understanding oncogenic processes and for cancer's clinical management. Variation in driver…”
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Identification of Recurrent Activating HER2 Mutations in Primary Canine Pulmonary Adenocarcinoma by Lorch, Gwendolen, Sivaprakasam, Karthigayini, Zismann, Victoria, Perdigones, Nieves, Contente-Cuomo, Tania, Nazareno, Alexandra, Facista, Salvatore, Wong, Shukmei, Drenner, Kevin, Liang, Winnie S, Amann, Joseph M, Sinicropi-Yao, Sara L, Koenig, Michael J, La Perle, Krista, Whitsett, Timothy G, Murtaza, Muhammed, Trent, Jeffrey M, Carbone, David P, Hendricks, William P D

“…Naturally occurring primary canine lung cancers share clinicopathologic features with human lung cancers in never-smokers, but the genetic underpinnings of…”
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Abstract 4312: Identification of shared mutations across many parallel human and canine cancers based on comprehensive survey of canine cancer mutations and the “caninization” of human mutations from COSMIC by Sakthikumar, Sharadha, Facista, Salvatore, Whitley, Derick, Warrier, Manisha, Hendricks, William, Wang, Guannan

“…Abstract Introduction: Vidium Insight™ is a canine cancer genomic biomarker database built from exhaustive curation of peer-reviewed literature describing…”
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Ponatinib Shows Potent Antitumor Activity in Small Cell Carcinoma of the Ovary Hypercalcemic Type (SCCOHT) through Multikinase Inhibition by Lang, Jessica D, Hendricks, William P D, Orlando, Krystal A, Yin, Hongwei, Kiefer, Jeffrey, Ramos, Pilar, Sharma, Ritin, Pirrotte, Patrick, Raupach, Elizabeth A, Sereduk, Chris, Tang, Nanyun, Liang, Winnie S, Washington, Megan, Facista, Salvatore J, Zismann, Victoria L, Cousins, Emily M, Major, Michael B, Wang, Yemin, Karnezis, Anthony N, Sekulic, Aleksandar, Hass, Ralf, Vanderhyden, Barbara C, Nair, Praveen, Weissman, Bernard E, Huntsman, David G, Trent, Jeffrey M

“…Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare, aggressive ovarian cancer in young women that is universally driven by loss of the…”
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Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC by Sakthikumar, Sharadha, Facista, Salvatore, Whitley, Derick, Byron, Sara A., Ahmed, Zeeshan, Warrier, Manisha, Zhu, Zhanyang, Chon, Esther, Banovich, Kathryn, Haworth, David, Hendricks, William P. D., Wang, Guannan

“…The accrual of cancer mutation data and related functional and clinical associations have revolutionised human oncology, enabling the advancement of precision…”
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Abstract LB-038: Novel functional insights revealed by distinct protein-protein interactions of the residual SWI/SNF complex in SMARCA4-deficient small cell carcinoma of the ovary, hypercalcemic type by Raupach, Elizabeth, Garcia-Mansfield, Krystine, Sharma, Ritin, Hegde, Apurva, David-Dirgo, Victoria, Wang, Yemin, Shin, Chae Young, Tao, Lan, Facista, Salvatore, Moore, Rayvon, Lang, Jessica, Zismann, Victoria, Orlando, Krystal, Spillman, Monique, Karnezis, Anthony, Bennett, Lynda, Huntsman, David, Trent, Jeffrey, Hendricks, William, Weissman, Bernard, Pirrotte, Patrick

“…Abstract Chromatin remodeling plays a critical role in tumor suppression as demonstrated by 20% of human cancers bearing inactivating mutations in SWI/SNF…”
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Genomic analysis across 53 canine cancer types reveals novel mutations and high clinical actionability potential by Sakthikumar, Sharadha, Warrier, Manisha, Whitley, Derick, Facista, Salvatore, Adkins, Jonathan, Aman, Sara, Tsinajinnie, Darwin, Duran, Natalie, Siravegna, Giulia, Ahmed, Zeeshan, Day, Kenneth, Jenkins, Brooklyn, Patel, Nidhi, Ryden, Kirk, Nadai, Joe, Banovich, Kathryn, Powers, Barbara, Edwards, Jeffrey, Steinberg, Jennifer, Fielder, Susan, Wong, Shukmei, Byron, Sara A., Izatt, Tyler, Zismann, Victoria, Boateng, Martin, Zhu, Zhanyang, Chuang, Han‐Yu, Trent, Jeffrey M., Haworth, David, Chon, Esther, Hendricks, William, Wang, Guannan

“…A genomic understanding of the oncogenic processes and individual variability of human cancer has steadily fueled improvement in patient outcomes over the past…”
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Abstract 3705: Identification of frequent HER2 activating mutations in canine primary pulmonary adenocarcinoma by Lorch, Gwendolen, Sivaprakasam, Karthigayini, Zissman, Victoria, Perdigones, Nieves, Contente-Cuomo, Tania, Nazareno, Alexandra, Facista, Salvatore, Wong, ShukMei, Liang, Winnie, Amann, Joseph M., Sinicropi-Yao, Sara L., Koenig, Michael J., Perle, Krista La, Whitsett, Timothy G., Murtaza, Muhammed, Trent, Jeffrey, Carbone, David P., Hendricks, William P.

“…Abstract Spontaneous primary canine lung cancers are aggressive malignancies that are increasingly common in dogs. They share clinicopathologic features with…”
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PD-1-Associated Gene Expression Signature of Neoadjuvant Trastuzumab-Treated Tumors Correlates with Patient Survival in HER2-Positive Breast Cancer by Hendricks, William P. D., Briones, Natalia, Halperin, Rebecca F., Facista, Salvatore, Heaton, Paul R., Mahadevan, Daruka, Kim, Suwon

“…The therapeutic HER2-targeting antibody trastuzumab has been shown to elicit tumor immune response in a subset of HER2-positive (HER2+) breast cancer. We…”
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Ponatinib shows potent antitumor activity in small cell carcinoma of the ovary hypercalcemic type (SCCOHT) through multi-kinase inhibition by Lang, Jessica D., Hendricks, William P. D., Orlando, Krystal A., Yin, Hongwei Holly, Kiefer, Jeffrey, Ramos, Pilar, Sharma, Ritin, Pirrotte, Patrick, Raupach, Elizabeth A, Sereduk, Chris, Tang, Nanyun, Liang, Winnie, Washington, Megan, Facista, Salvatore J., Zismann, Victoria L., Cousins, Emily M., Major, Michael B., Wang, Yemin, Karnezis, Anthony N., Sekulic, Aleksandar, Hass, Ralf, Vanderhyden, Barbara, Praveen, Kesavannair, Weissman, Bernard E., Huntsman, David G., Trent, Jeffrey M.

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Identification of Genetic Susceptibility Factors Associated with Canine Gastric Dilatation-Volvulus by Piras, Ignazio S., Perdigones, Nieves, Zismann, Victoria, Briones, Natalia, Facista, Salvatore, Rivera, José Luis, Rozanski, Elizabeth, London, Cheryl A., Hendricks, William P. D.

“…Canine gastric dilatation-volvulus (GDV) is a common life-threatening condition occurring primarily in large and giant breeds with a 3.9% to 36.7% lifetime…”
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Canine osteosarcoma genome sequencing identifies recurrent mutations in DMD and the histone methyltransferase gene SETD2 by Gardner, Heather L, Sivaprakasam, Karthigayini, Briones, Natalia, Zismann, Victoria, Perdigones, Nieves, Drenner, Kevin, Facista, Salvatore, Richholt, Ryan, Liang, Winnie, Aldrich, Jessica, Trent, Jeffrey M, Shields, Peter G, Robinson, Nicholas, Johnson, Jeremy, Lana, Susan, Houghton, Peter, Fenger, Joelle, Lorch, Gwendolen, Janeway, Katherine A, London, Cheryl A, Hendricks, William P D

“…Osteosarcoma (OS) is a rare, metastatic, human adolescent cancer that also occurs in pet dogs. To define the genomic underpinnings of canine OS, we performed…”
Get full text