Search Results - "Facciotti, Marc T."
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Evaluation of algorithm performance in ChIP-seq peak detection
Published in PloS one (08-07-2010)“…Next-generation DNA sequencing coupled with chromatin immunoprecipitation (ChIP-seq) is revolutionizing our ability to interrogate whole genome protein-DNA…”
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An integrated pipeline for de novo assembly of microbial genomes
Published in PloS one (13-09-2012)“…Remarkable advances in DNA sequencing technology have created a need for de novo genome assembly methods tailored to work with the new sequencing data types…”
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Phylogenetically driven sequencing of extremely halophilic archaea reveals strategies for static and dynamic osmo-response
Published in PLoS genetics (01-11-2014)“…Organisms across the tree of life use a variety of mechanisms to respond to stress-inducing fluctuations in osmotic conditions. Cellular response mechanisms…”
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Thermodynamically inspired classifier for molecular phenotypes of health and disease
Published in Proceedings of the National Academy of Sciences - PNAS (26-11-2013)Get full text
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Microscale sulfur cycling in the phototrophic pink berry consortia of the Sippewissett Salt Marsh
Published in Environmental microbiology (01-11-2014)“…Summary Microbial metabolism is the engine that drives global biogeochemical cycles, yet many key transformations are carried out by microbial consortia over…”
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Candidatus Frankia Datiscae Dg1, the Actinobacterial Microsymbiont of Datisca glomerata, Expresses the Canonical nod Genes nodABC in Symbiosis with Its Host Plant
Published in PloS one (28-05-2015)“…Frankia strains are nitrogen-fixing soil actinobacteria that can form root symbioses with actinorhizal plants. Phylogenetically, symbiotic frankiae can be…”
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IRF-1 and miRNA126 Modulate VCAM-1 Expression in Response to a High-Fat Meal
Published in Circulation research (28-09-2012)“…RATIONALE:A high-fat diet accompanied by hypertriglyceridemia increases an individual’s risk for development of atherosclerosis. An early event in this process…”
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Deprotonation of D96 in Bacteriorhodopsin Opens the Proton Uptake Pathway
Published in Structure (London) (05-02-2013)“…Despite extensive investigation, the precise mechanism controlling the opening of the cytoplasmic proton uptake pathway in bacteriorhodopsin (bR) has remained…”
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A Predictive Model for Transcriptional Control of Physiology in a Free Living Cell
Published in Cell (28-12-2007)“…The environment significantly influences the dynamic expression and assembly of all components encoded in the genome of an organism into functional biological…”
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A Large and Phylogenetically Diverse Class of Type 1 Opsins Lacking a Canonical Retinal Binding Site
Published in PloS one (21-06-2016)“…Opsins are photosensitive proteins catalyzing light-dependent processes across the tree of life. For both microbial (type 1) and metazoan (type 2) opsins,…”
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Schiff base switch II precedes the retinal thermal isomerization in the photocycle of bacteriorhodopsin
Published in PloS one (29-07-2013)“…In bacteriorhodopsin, the order of molecular events that control the cytoplasmic or extracellular accessibility of the Schiff bases (SB) are not well…”
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Role of Squalene in the Organization of Monolayers Derived from Lipid Extracts of Halobacterium salinarum
Published in Langmuir (25-06-2013)“…We have studied interfacial compressibility and lateral organization in monolayer configurations of total (squalene containing) and polar (squalene-devoid)…”
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Combining Microbial Culturing With Mathematical Modeling in an Introductory Course-Based Undergraduate Research Experience
Published in Frontiers in microbiology (06-11-2020)“…Quantitative techniques are a critical part of contemporary biology research, but students interested in biology enter college with widely varying quantitative…”
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Genome sequence of Haloarcula marismortui: a halophilic archaeon from the Dead Sea
Published in Genome research (01-11-2004)“…We report the complete sequence of the 4,274,642-bp genome of Haloarcula marismortui, a halophilic archaeal isolate from the Dead Sea. The genome is organized…”
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The Exploration of Novel Regulatory Relationships Drives Haloarchaeal Operon-Like Structural Dynamics over Short Evolutionary Distances
Published in Microorganisms (Basel) (30-11-2020)“…Operons are a dominant feature of bacterial and archaeal genome organization. Numerous investigations have related aspects of operon structure to operon…”
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Prevalence of transcription promoters within archaeal operons and coding sequences
Published in Molecular systems biology (16-06-2009)“…Despite the knowledge of complex prokaryotic‐transcription mechanisms, generalized rules, such as the simplified organization of genes into operons with…”
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Gene Gangs of the Chloroviruses: Conserved Clusters of Collinear Monocistronic Genes
Published in Viruses (20-10-2018)“…Chloroviruses (family ) are dsDNA viruses found throughout the world's inland waters. The open reading frames in the genomes of 41 sequenced chloroviruses (330…”
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JContextExplorer: a tree-based approach to facilitate cross-species genomic context comparison
Published in BMC bioinformatics (16-01-2013)“…Cross-species comparisons of gene neighborhoods (also called genomic contexts) in microbes may provide insight into determining functionally related or…”
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Conserved substitution patterns around nucleosome footprints in eukaryotes and Archaea derive from frequent nucleosome repositioning through evolution
Published in PLoS computational biology (01-11-2013)“…Nucleosomes, the basic repeat units of eukaryotic chromatin, have been suggested to influence the evolution of eukaryotic genomes, both by altering the…”
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General Transcription Factor Specified Global Gene Regulation in Archaea
Published in Proceedings of the National Academy of Sciences - PNAS (13-03-2007)“…Cells responding to dramatic environmental changes or undergoing a developmental switch typically change the expression of numerous genes. In bacteria, σ…”
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