Search Results - "Faccinetti, Natalia"

Immunological and clinical characteristics of latent autoimmune diabetes in the elderly by Yohena, Silvina, Penas‐Steinhardt, Alberto, Muller, Clara, Faccinetti, Natalia I., Cerrone, Gloria E., Lovecchio, Silvia, Ridner, Edgardo, Valdez, Silvina, Frechtel, Gustavo

“…Background: Latent autoimmune diabetes in adults (LADA) is determined by both a noninsulin‐dependent clinical presentation and an autoimmune pathogenic…”
Get full text

Characterization of insulin antibodies by Surface Plasmon Resonance in two clinical cases: brittle diabetes and insulin autoimmune syndrome by Trabucchi, Aldana, Iacono, Ruben F, Guerra, Luciano L, Faccinetti, Natalia I, Krochik, Andrea G, Arriazu, María C, Poskus, Edgardo, Valdez, Silvina N

“…In this study, the characterization of insulin (auto)antibodies has been described, mainly in terms of concentration (q), affinity (Ka) and Ig (sub)isotypes by…”
Get full text

Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application by Guerra, Luciano Lucas, Faccinetti, Natalia Inés, Trabucchi, Aldana, Rovitto, Bruno David, Sabljic, Adriana Victoria, Poskus, Edgardo, Iacono, Ruben Francisco, Valdez, Silvina Noemí

“…The insulinoma associated protein tyrosine phosphatase 2 (IA-2) is one of the immunodominant autoantigens involved in the autoimmune attack to the beta-cell in…”
Get full text

Novel Flow Cytometric Immunoassay for Detection of Proinsulin Autoantibodies in Diabetes Mellitus Employing a Recombinant Autoantigen Expressed in E. coli by Sabljic, Adriana Victoria, Bombicino, Silvina Sonia, Marfía, Juan Ignacio, Guerra, Luciano Lucas, Steinhardt, Alberto Penas, Faccinetti, Natalia Inés, Iacono, Rubén Francisco, Poskus, Edgardo, Trabucchi, Aldana, Valdez, Silvina Noemí

“…Insulin and proinsulin autoantibodies (IAA/PAA) are usually the first markers to appear in patients with type 1 Diabetes Mellitus (T1DM) and their prevalence…”
Get full text

Surface plasmon resonance reveals a different pattern of proinsulin autoantibodies concentration and affinity in diabetic patients by Trabucchi, Aldana, Guerra, Luciano L, Faccinetti, Natalia I, Iacono, Rubén F, Poskus, Edgardo, Valdez, Silvina N

“…Type 1 diabetes mellitus (DM) is characterized by autoimmune aggression against pancreatic beta cells resulting in absolute deficiency of insulin secretion…”
Get full text

Expression of recombinant glutamic acid decarboxylase in insect larvae and its application in an immunoassay for the diagnosis of autoimmune diabetes mellitus by Trabucchi, Aldana, Bombicino, Silvina S., Targovnik, Alexandra M., Marfía, Juan I., Sabljic, Adriana V., Faccinetti, Natalia I., Guerra, Luciano L., Iacono, Ruben F., Miranda, María V., Valdez, Silvina N.

“…Autoimmune Diabetes Mellitus (DM) is a chronic disease caused by the selective destruction of insulin producing beta cells in human pancreas. DM is…”
Get full text

Expression and characterization of human proinsulin fused to thioredoxin in Escherichia coli by Trabucchi, Aldana, Guerra, Luciano Lucas, Faccinetti, Natalia Inés, Iacono, Ruben Francisco, Poskus, Edgardo, Valdez, Silvina Noemí

“…Native proinsulin (PI) belongs to the class of the difficult-to-express proteins in Escherichia coli. Problems mainly arise due to its high proteolytic decay…”
Get full text

Prokaryotic expression and characterization of the heterodimeric construction of ZnT8 and its application for autoantibodies detection in diabetes mellitus by Faccinetti, Natalia I, Guerra, Luciano L, Sabljic, Adriana V, Bombicino, Silvina S, Rovitto, Bruno D, Iacono, Ruben F, Poskus, Edgardo, Trabucchi, Aldana, Valdez, Silvina N

“…In the present work we described the recombinant production and characterization of heterodimeric construction ZnT8-Arg-Trp325 fused to thioredoxin using a…”
Get full text

Characterization of zinc transporter 8 (ZnT8) antibodies in autoimmune diabetic patients from Argentinian population using monomeric, homodimeric, and heterodimeric ZnT8 antigen variants by Faccinetti, Natalia I, Guerra, Luciano L, Penas Steinhardt, Alberto, Iacono, Ruben F, Frechtel, Gustavo D, Trifone, Liliana, Poskus, Edgardo, Trabucchi, Aldana, Valdez, Silvina N

“…Objective In order to gain further knowledge of the structure of zinc transporter 8 (ZnT8) epitopes, we studied the role of the amino acid at position 325 in…”
Get full text

Flow cytometric microsphere-based immunoassay as a novel non-radiometric method for the detection of glutamic acid decarboxylase autoantibodies in type 1 diabetes mellitus by Guerra, Luciano L, Trabucchi, Aldana, Faccinetti, Natalia I, Iacono, Ruben F, Ureta, Daniela B, Poskus, Edgardo, Valdez, Silvina N

“…The first measurable sign of arising autoimmunity in type 1 diabetes mellitus is the detection of autoantibodies against beta-cell antigens, such as glutamic…”
Get more information

Detection and characterization of ZnT8 autoantibodies could help to screen latent autoimmune diabetes in adult-onset patients with type 2 phenotype by Trabucchi, Aldana, Faccinetti, Natalia I., Guerra, Luciano L., Puchulu, Félix M., Frechtel, Gustavo D., Poskus, Edgardo, Valdez, Silvina N.

“…Autoantibodies to zinc transporter 8 (ZnT8A) constitute an additional marker of autoimmune diabetes, complementing those already used in diagnosis support…”
Get full text

INMUNOENSAYO MULTIPLEX PARA EL DIAGNÓSTICO SIMULTÁNEO DE DIABETES MELLITUS AUTOINMUNE Y ENFERMEDAD CELÍACA by Bombicino, Silvia, Sabljic, Adriana, Faccinetti, Natalia, Guerra, Luciano, Marfía, Juan, Masci, Ivana, Trabucchi, Aldana, Poskus, Edgardo, Valdez, Silvina

“…Introducción: la diabetes mellitus autoinmune (DMA) y la enfermedad celíaca (EC) son enfermedades crónicas, poligénicas y multifactoriales vinculadas con la…”
Get full text

MULTIPLEX IMMUNOASSAY FOR SIMULTANEOUS DIAGNOSTIC OF AUTOIMMUNE DIABETES MELLITUS AND CELIAC DISEASE by Silvia Bombicino, Adriana Sabljic, Natalia Faccinetti, Luciano Guerra, Juan Marfía, Ivana Masci, Aldana Trabucchi, Edgardo Poskus, Silvina Valdez

“…Introduction: autoimmune diabetes mellitus (ADM) and celiac disease (CD) are chronic, polygenic and multifactorial diseases associated with immune system…”
Get full text

Prokariotic expression of major autoantigens from Diabetes Mellitus fused to thioredoxin: IA-2 and ZnT8 by Luciano, Guerra, Natalia, Faccinetti, Bruno, Rovitto, Ruben, Iacono, Edgardo, Poskus, Aldana, Trabucchi, Silvina, Valdez

“…Abstract only…”
Get full text

BETA CELL AUTOIMMUNITY IN ELEDERLY WITH TYPE 2 DIABETES: LINICAL, METABOLIC AND THERAPEUTIC IMPACT by Edgardo Ridner, Silvana Yohena, Facundo Tornelli, Clara Muller, Silvina Díaz, Silvia Lovecchio, Natalia Faccinetti, Silvina Valdez, Luciano Guerra, Gustavo Frechtel

“…Introduction: 111 patients with diabetes with over 65 years old and non-obese (BMI <30.0 kg/m2), were studied. Methods: GADA, ZnT8, IA2a and PAA, 4 antibody…”
Get full text

Novedoso inmunoensayo multiplex por Citometría de Flujo para la detección simultánea y discriminativa de GADA e IA2A en pacientes con Diabetes Mellitus by Guerra, Luciano Lucas, Faccinetti, Natalia Inés, Bombicino, Silvina Sonia, Rovitto, Bruno David, Sabljic, Adriana Victoria, Trabucchi, Aldana, Penas Steinhardt, Alberto, Poskus, Edgardo, Iacono, Ruben Francisco, Valdez, Silvina Noemí

“…La Diabetes Mellitus tipo 1 (DMT1) es un trastorno autoinmune con pérdida de tolerancia hacia antígenos de las células beta-pancreáticas y presenta…”
Get full text

Characterization of Insulin Antibodies by Surface Plasmon Resonance in Two Clinical Cases: Brittle Diabetes and Insulin Autoimmune Syndrome: e84099 by Trabucchi, Aldana, Iacono, Ruben F, Guerra, Luciano L, Faccinetti, Natalia I, Krochik, Andrea G, Arriazu, Maria C, Poskus, Edgardo, Valdez, Silvina N

“…In this study, the characterization of insulin (auto)antibodies has been described, mainly in terms of concentration (q), affinity (Ka) and Ig (sub)isotypes by…”
Get full text

Detección y caracterización de autoanticuerpos anti-ZnT8 en pacientes argentinos con diabetes mellitus tipo 1 by Faccinetti, Natalia Inés, Rovitto, Bruno David, Guerra, Luciano Lucas, Sabljic, Adriana Victoria, Iacono, Ruben Francisco, Trifone, Liliana, Poskus, Edgardo, Trabucchi, Aldana, Valdez, Silvina Noemí

“…El transportador de Zn8 (ZnT8), identificado como el cuarto autoantígeno inmunodominante en la diabetes mellitus (DM) tipo 1, presenta un polimorfismo en el…”
Get full text