Search Results - "Faccidomo, Sara"

Moderate Alcohol Drinking and the Amygdala Proteome: Identification and Validation of Calcium/Calmodulin Dependent Kinase II and AMPA Receptor Activity as Novel Molecular Mechanisms of the Positive Reinforcing Effects of Alcohol by Salling, Michael C, Faccidomo, Sara P, Li, Chia, Psilos, Kelly, Galunas, Christina, Spanos, Marina, Agoglia, Abigail E, Kash, Thomas L, Hodge, Clyde W

“…Abstract Background Despite worldwide consumption of moderate amounts of alcohol, the neural mechanisms that mediate the transition from use to abuse are not…”
Get full text

Manipulations of Central Amygdala Neurotensin Neurons Alter the Consumption of Ethanol and Sweet Fluids in Mice by Torruella-Suárez, María Luisa, Vandenberg, Jessica R, Cogan, Elizabeth S, Tipton, Gregory J, Teklezghi, Adonay, Dange, Kedar, Patel, Gunjan K, McHenry, Jenna A, Hardaway, J Andrew, Kantak, Pranish A, Crowley, Nicole A, DiBerto, Jeffrey F, Faccidomo, Sara P, Hodge, Clyde W, Stuber, Garret D, McElligott, Zoé A

“…The central nucleus of the amygdala plays a significant role in alcohol use and other affective disorders; however, the genetically-defined neuronal subtypes…”
Get full text

Negative modulation of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner in male mice by Hoffman, Jessica L., Faccidomo, Sara P., Taylor, Seth M., DeMiceli, Kristina G., May, Ashley M., Smith, Evan N., Whindleton, Ciarra M., Hodge, Clyde W.

“…Rationale The development and progression of alcohol use disorder (AUD) are widely viewed as maladaptive neuroplasticity. The transmembrane…”
Get full text

Cue-induced reinstatement of alcohol-seeking behavior is associated with increased CaMKII T286 phosphorylation in the reward pathway of mice by Salling, Michael C., Hodge, Christopher J., Psilos, Kelly E., Eastman, Vallari R., Faccidomo, Sara P., Hodge, Clyde W.

“…Cue-induced reinstatement of alcohol-seeking is a hallmark behavioral pathology of addiction. Evidence suggests that reinstatement (e.g., relapse), may be…”
Get full text

MGluR5 activity is required for the induction of ethanol behavioral sensitization and associated changes in ERK MAP kinase phosphorylation in the nucleus accumbens shell and lateral habenula by Stevenson, Rebekah A., Hoffman, Jessica L., Maldonado-Devincci, Antoniette M., Faccidomo, Sara, Hodge, Clyde W.

“…•Repeated alcohol administration produces robust locomotor sensitization in male DBA/2J mice.•Treatment with the mGluR5 antagonist MPEP blunts the induction of…”
Get full text

Escalated Aggression after Alcohol Drinking in Male Mice : Dorsal Raphé and Prefrontal Cortex Serotonin and 5-HT1B Receptors by FACCIDOMO, Sara, BANNAI, Makoto, MICZEK, Klaus A

“…A significant minority of individuals engages in escalated levels of aggression after consuming moderate doses of alcohol (Alc). Neural modulation of escalated…”
Get full text

Anti-aggressive effects of agonists at 5-HT1B receptors in the dorsal raphe nucleus of mice by BANNAI, Makoto, FISH, Eric W, FACCIDOMO, Sara, MICZEK, Klaus A

“…In rodents, serotonin 1B (5-HT(1B)) agonists specifically reduce aggressive behaviors, including several forms of escalated aggression. One form of escalated…”
Get full text

Repeated maternal separation : differences in cocaine-induced behavioral sensitization in adult male and female mice by KIKUSUI, Takefumi, FACCIDOMO, Sara, MICZEK, Klaus A

“…Repeated maternal separations profoundly alter the adult stress response, the development of the hypothalamic-pituitary-adrenal axis, and prominently, the…”
Get full text

Glutamatergic and GABAergic modulations of ultrasonic vocalizations during maternal separation distress in mouse pups by Takahashi, Aki, Yap, Jasmine J., Bohager, Dawnya Zitzman, Faccidomo, Sara, Clayton, Terry, Cook, James M., Miczek, Klaus A.

“…Introduction Dysregulation of GABAergic inhibition and glutamatergic excitation has been implicated in exaggerated anxiety. Mouse pups emit distress-like…”
Get full text

Anxiolytic-like effects of escitalopram, citalopram, and R-citalopram in maternally separated mouse pups by Fish, Eric W, Faccidomo, Sara, Gupta, Sandeep, Miczek, Klaus A

“…The S-enantiomer of citalopram, escitalopram, is a selective serotonin reuptake inhibitor (SSRI) that appears to be responsible for citalopram's antidepressant…”
Get more information

Escalated Aggressive Behavior: New Pharmacotherapeutic Approaches and Opportunities by MICZEK, KLAUS A., FACCIDOMO, SARA, De ALMEIDA, ROSA M. M., BANNAI, MAKOTO, FISH, ERIC W., DEBOLD, JOSEPH F.

“…: Psychopharmacologic studies of aggressive behavior in animals under controlled laboratory conditions have been instrumental in developing and evaluating…”
Get full text

Role of Alcohol Consumption in Escalation to Violence by MICZEK, KLAUS A., FISH, ERIC W., De ALMEIDA, ROSA M. M., FACCIDOMO, SARA, DEBOLD, JOSEPH F.

“…: No other drug has been associated with aggressive and violent behavior more than alcohol has. A major characteristic of the link between alcohol and social…”
Get full text

Negative modulation of AMPA receptors bound to transmembrane AMPA receptor regulatory protein [gamma]-8 blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner in male mice by Hoffman, Jessica L, Faccidomo, Sara P, Taylor, Seth M, DeMiceli, Kristina G, May, Ashley M, Smith, Evan N, Whindleton, Ciarra M

“…Rationale The development and progression of alcohol use disorder (AUD) are widely viewed as maladaptive neuroplasticity. The transmembrane…”
Get full text

Inhibition of AMPA receptors (AMPARs) containing transmembrane AMPAR regulatory protein γ‐8 with JNJ‐55511118 shows preclinical efficacy in reducing chronic repetitive alcohol self‐administration by Hoffman, Jessica L., Faccidomo, Sara, Saunders, Briana L., Taylor, Seth M., Kim, Michelle, Hodge, Clyde W.

“…Background A prominent therapeutic indication for alcohol use disorder (AUD) is reduction in chronic repetitive alcohol use. Glutamate…”
Get full text

Operant ethanol self-administration increases extracellular-signal regulated protein kinase (ERK) phosphorylation in reward-related brain regions: selective regulation of positive reinforcement in the prefrontal cortex of C57BL/6J mice by Faccidomo, Sara, Salling, Michael C., Galunas, Christina, Hodge, Clyde W.

“…Rationale Extracellular-signal regulated protein kinase (ERK1/2) is activated by ethanol in reward-related brain regions. Accordingly, systemic inhibition of…”
Get full text

Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease by Hoffman, Jessica L, Faccidomo, Sara, Kim, Michelle, Taylor, Seth M, Agoglia, Abigail E, May, Ashley M, Smith, Evan N, Wong, L C, Hodge, Clyde W

“…Alzheimer's disease (AD) is a progressive neurodegenerative disorder that represents the most common cause of dementia in the United States. Although the link…”
Get more information

Zolmitriptan - a 5-HT 1B/D agonist, alcohol, and aggression in mice by de Almeida, Rosa, Nikulina, Ella, Faccidomo, Sara, Fish, Eric, Miczek, Klaus

Get full text

Metabotropic Glutamate Receptor 5 Activity in the Nucleus Accumbens Is Required for the Maintenance of Ethanol Self-Administration in a Rat Genetic Model of High Alcohol Intake by Besheer, Joyce, Grondin, Julie J.M, Cannady, Reginald, Sharko, Amanda C, Faccidomo, Sara, Hodge, Clyde W

“…Background Systemic modulation of Group I and II metabotropic glutamate receptors (mGluRs) regulate ethanol self-administration in a variety of animal models…”
Get full text

CaMKII inhibition in the prefrontal cortex specifically increases the positive reinforcing effects of sweetened alcohol in C57BL/6J mice by Faccidomo, Sara, Reid, Grant T., Agoglia, Abigail E., Ademola, Sherifat A., Hodge, Clyde W.

“…•CAMKII activity is important for neural plasticity and development of drug addiction.•Moderate alcohol drinking alters CaMKII expression and phosphorylation…”
Get full text

Alcohol-heightened aggression in mice: attenuation by 5-HT 1A receptor agonists by Miczek, Klaus A., Hussain, Subuhee, Faccidomo, Sara

Get full text