Search Results - "Facchini, Andrea"

Signaling pathways in cartilage repair by Mariani, Erminia, Pulsatelli, Lia, Facchini, Andrea

“…In adult healthy cartilage, chondrocytes are in a quiescent phase characterized by a fine balance between anabolic and catabolic activities. In ageing,…”
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Intra-articular delivery of adipose derived stromal cells attenuates osteoarthritis progression in an experimental rabbit model by Desando, Giovanna, Cavallo, Carola, Sartoni, Federica, Martini, Lucia, Parrilli, Annapaola, Veronesi, Francesca, Fini, Milena, Giardino, Roberto, Facchini, Andrea, Grigolo, Brunella

“…Cell therapy is a rapidly growing area of research for the treatment of osteoarthritis (OA). This work is aimed to investigate the efficacy of intra-articular…”
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Adipose‐Derived Mesenchymal Stem Cells Exert Antiinflammatory Effects on Chondrocytes and Synoviocytes From Osteoarthritis Patients Through Prostaglandin E2 by Manferdini, Cristina, Maumus, Marie, Gabusi, Elena, Piacentini, Anna, Filardo, Giuseppe, Peyrafitte, Julie‐Anne, Jorgensen, Christian, Bourin, Philippe, Fleury‐Cappellesso, Sandrine, Facchini, Andrea, Noël, Danièle, Lisignoli, Gina

“…Objective To examine the effect of different sources of Good Manufacturing Practice clinical grade adipose‐derived mesenchymal stem cells (AD‐MSCs) on…”
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Effect of two different preparations of platelet-rich plasma on synoviocytes by Assirelli, Elisa, Filardo, Giuseppe, Mariani, Erminia, Kon, Elizaveta, Roffi, Alice, Vaccaro, Franca, Marcacci, Maurilio, Facchini, Andrea, Pulsatelli, Lia

“…Purpose To analyse the modifications induced by two different platelet-rich plasma (PRP) preparations on osteoarthritis (OA) synoviocytes, by documenting…”
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Sodium hydrosulfide inhibits the differentiation of osteoclast progenitor cells via NRF2-dependent mechanism by Gambari, Laura, Lisignoli, Gina, Cattini, Luca, Manferdini, Cristina, Facchini, Andrea, Grassi, Francesco

“…Hydrogen sulfide (H2S), which recently emerged as a potent regulator of tissues and organs, is broadly produced in mammalian cells but whether it can regulate…”
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Conceptual frameworks and empirical approaches used to assess the impact of health research: an overview of reviews by Banzi, Rita, Moja, Lorenzo, Pistotti, Vanna, Facchini, Andrea, Liberati, Alessandro

“…How to assess the impact of research is of growing interest to funders, policy makers and researchers mainly to understand the value of investments and to…”
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Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1β-stimulated production of chemokines and matrix-degrading enzymes in vitro by Assirelli, Elisa, Pulsatelli, Lia, Dolzani, Paolo, Platano, Daniela, Olivotto, Eleonora, Filardo, Giuseppe, Trisolino, Giovanni, Facchini, Andrea, Borzì, Rosa Maria, Meliconi, Riccardo

“…In osteoarthritis (OA), an inflammatory environment is responsible for the imbalance between the anabolic and catabolic activity of chondrocytes and, thus, for…”
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Hydroxytyrosol prevents increase of osteoarthritis markers in human chondrocytes treated with hydrogen peroxide or growth-related oncogene α by Facchini, Annalisa, Cetrullo, Silvia, D'Adamo, Stefania, Guidotti, Serena, Minguzzi, Manuela, Facchini, Andrea, Borzì, Rosa Maria, Flamigni, Flavio

“…Hydroxytyrosol (HT), a phenolic compound mainly derived from olives, has been proposed as a nutraceutical useful in prevention or treatment of degenerative…”
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Human adipose stromal cells (ASC) for the regeneration of injured cartilage display genetic stability after in vitro culture expansion by Neri, Simona, Bourin, Philippe, Peyrafitte, Julie-Anne, Cattini, Luca, Facchini, Andrea, Mariani, Erminia

“…Mesenchymal stromal cells are emerging as an extremely promising therapeutic agent for tissue regeneration due to their multi-potency, immune-modulation and…”
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Platelet-rich plasma affects bacterial growth in vitro by Mariani, Erminia, Filardo, Giuseppe, Canella, Valentina, Berlingeri, Andrea, Bielli, Alessandra, Cattini, Luca, Landini, Maria Paola, Kon, Elizaveta, Marcacci, Maurilio, Facchini, Andrea

“…Abstract Background aims Platelet-rich plasma (PRP), a blood derivative rich in platelets, is a relatively new technique used in tissue regeneration and…”
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Chondrogenic differentiation of bone marrow concentrate grown onto a hylauronan scaffold: Rationale for its use in the treatment of cartilage lesions by Cavallo, Carola, Desando, Giovanna, Columbaro, Marta, Ferrari, Andrea, Zini, Nicoletta, Facchini, Andrea, Grigolo, Brunella

“…Bone marrow is one of the best characterized stem cell microenvironment that contains Mesenchymal Stem Cells (MSCs). MSCs have been indicated as a new option…”
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IKKα/CHUK regulates extracellular matrix remodeling independent of its kinase activity to facilitate articular chondrocyte differentiation by Olivotto, Eleonora, Otero, Miguel, Astolfi, Annalisa, Platano, Daniela, Facchini, Annalisa, Pagani, Stefania, Flamigni, Flavio, Facchini, Andrea, Goldring, Mary B, Borzì, Rosa Maria, Marcu, Kenneth B

“…The non-canonical NF-κB activating kinase IKKα, encoded by CHUK (conserved-helix-loop-helix-ubiquitous-kinase), has been reported to modulate pro- or anti-…”
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Impact of COVID-19 Pandemic on Treatment and Outcome of Fragility Hip Fractures In Non-COVID Patients: Comparison Between the Lockdown Period, a Historical Series and the “Pandemic Normality” in a Single Institution by Troiano, Elisa, De Sensi, Alice Giulia, Zanasi, Francesco, Facchini, Andrea, De Marco, Giulia, Colasanti, Giovanni Battista, Mondanelli, Nicola, Giannotti, Stefano

“…Introduction The COVID-19 pandemic has affected and is still deeply affecting all aspects of public life. World governments have been forced to enact…”
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Treatment Algorithm of Periprosthetic Femoral Fracturens by Mondanelli, Nicola, Troiano, Elisa, Facchini, Andrea, Ghezzi, Roberta, Di Meglio, Martina, Nuvoli, Nicolò, Peri, Giacomo, Aiuto, Pietro, Colasanti, Giovanni Battista, Giannotti, Stefano

“…Introduction. The ever-expanding indications for total hip arthroplasty are leading to more implants being placed in younger as well as in older patients with…”
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New Insights into Osteogenic and Chondrogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells and Their Potential Clinical Applications for Bone Regeneration in Pediatric Orthopaedics by Lisignoli, Gina, Giuliani, Nicola, Magnani, Marina, Racano, Costantina, Bolzoni, Marina, Dalla Palma, Benedetta, Spolzino, Angelica, Manferdini, Cristina, Abati, Caterina, Toscani, Denise, Facchini, Andrea, Aversa, Franco

“…Human mesenchymal stem cells (hMSCs) are pluripotent adult stem cells capable of being differentiated into osteoblasts, adipocytes, and chondrocytes. The…”
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Co-culture of hematopoietic stem/progenitor cells with human osteblasts favours mono/macrophage differentiation at the expense of the erythroid lineage by Salati, Simona, Lisignoli, Gina, Manferdini, Cristina, Pennucci, Valentina, Zini, Roberta, Bianchi, Elisa, Norfo, Ruggiero, Facchini, Andrea, Ferrari, Sergio, Manfredini, Rossella

“…Hematopoietic stem cells (HSCs) are located in the bone marrow in a specific microenvironment referred as the hematopoietic stem cell niche, where HSCs…”
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Cellular and molecular events during chondrogenesis of human mesenchymal stromal cells grown in a three-dimensional hyaluronan based scaffold by Lisignoli, Gina, Cristino, Sandra, Piacentini, Anna, Toneguzzi, Stefania, Grassi, Francesco, Cavallo, Carola, Zini, Nicoletta, Solimando, Liliana, Mario Maraldi, Nadir, Facchini, Andrea

“…Mesenchymal stromal cells (MSCs) seem to be a good alternative to chondrocytes for cartilage regeneration. To obtain new information on the sequence of…”
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Calcein-acetyoxymethyl cytotoxicity assay: standardization of a method allowing additional analyses on recovered effector cells and supernatants by Neri, S, Mariani, E, Meneghetti, A, Cattini, L, Facchini, A

“…Cytotoxicity assays provide an in vitro evaluation of the lytic activity of NK and T cells against tumors or transformed cells. However, none of these methods…”
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Evidence for redifferentiation of human chondrocytes grown on a hyaluronan-based biomaterial (HYAFF ®11): molecular, immunohistochemical and ultrastructural analysis by Grigolo, Brunella, Lisignoli, Gina, Piacentini, Anna, Fiorini, Mauro, Gobbi, Pietro, Mazzotti, Giovanni, Duca, Manuela, Pavesio, Alessandra, Facchini, Andrea

“…Association of biomaterials with autologous cells can provide a new generation of implantable devices for cartilage repair. Such scaffolds should provide a…”
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Role of Slug transcription factor in human mesenchymal stem cells by Torreggiani, Elena, Lisignoli, Gina, Manferdini, Cristina, Lambertini, Elisabetta, Penolazzi, Letizia, Vecchiatini, Renata, Gabusi, Elena, Chieco, Pasquale, Facchini, Andrea, Gambari, Roberto, Piva, Roberta

“…The pathways that control mesenchymal stem cells (MSCs) differentiation are not well understood, and although some of the involved transcription factors (TFs)…”
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