Search Results - "Facchinetti, María M"

Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data by Degese, María S, Mendizabal, Javier E, Gandini, Norberto A, Gutkind, J. Silvio, Molinolo, Alfredo, Hewitt, Stephen M, Curino, Alejandro C, Coso, Omar A, Facchinetti, María M

“…Abstract While changes in heme oxygenase (HO-1) in lung cancer have already been reported, conflicting results were obtained for enzyme expression in human…”
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New insights on neurodegeneration triggered by iron accumulation: Intersections with neutral lipid metabolism, ferroptosis, and motor impairment by Maniscalchi, Athina, Benzi Juncos, Oriana N., Conde, Melisa A., Funk, Melania I., Fermento, María E., Facchinetti, María M., Curino, Alejandro C., Uranga, Romina M., Alza, Natalia P., Salvador, Gabriela A.

“…Brain iron accumulation constitutes a pathognomonic indicator in several neurodegenerative disorders. Metal accumulation associated with dopaminergic neuronal…”
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Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas by Gandini, Norberto A., Fermento, María E., Salomón, Débora G., Blasco, Jorge, Patel, Vyomesh, Gutkind, J. Silvio, Molinolo, Alfredo A., Facchinetti, María M., Curino, Alejandro C.

“…The expression of heme oxygenase-1 (HO-1) was shown to be increased in multiple tumors compared with their surrounding healthy tissues and was also observed to…”
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Vitamin D receptor expression is associated with improved overall survival in human glioblastoma multiforme by Salomón, Débora G., Fermento, María E., Gandini, Norberto A., Ferronato, María J., Arévalo, Julián, Blasco, Jorge, Andrés, Nancy C., Zenklusen, Jean C., Curino, Alejandro C., Facchinetti, María M.

“…Vitamin D and its analogs have been shown to display anti-proliferative effects in a wide variety of cancer types including glioblastoma multiforme (GBM)…”
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Inhibition of p300 suppresses growth of breast cancer. Role of p300 subcellular localization by Fermento, María E., Gandini, Norberto A., Salomón, Débora G., Ferronato, María J., Vitale, Cristian A., Arévalo, Julián, López Romero, Alejandro, Nuñez, Myriam, Jung, Manfred, Facchinetti, María M., Curino, Alejandro C.

“…There is evidence that p300, a transcriptional co-factor and a lysine acetyl-transferase, could play a role both as an oncoprotein and as a tumor suppressor,…”
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Novel calcitriol analogue with an oxolane group: In vitro, in vivo, and in silico studies by Obiol, Diego J., Martínez, Andrea, Ferronato, María J., Quevedo, Mario A., Grioli, Silvina M., Alonso, Eliana N., Gómez, Generosa, Fall, Yagamare, Facchinetti, María M., Curino, Alejandro C.

“…The active form of vitamin D3, calcitriol, is a potent antiproliferative compound. However, when effective antitumor doses of calcitriol are used,…”
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The expression of sphingosine kinase-1 in head and neck carcinoma by Facchinetti, María M, Gandini, Norberto A, Fermento, María E, Sterin-Speziale, Norma B, Ji, Youngmi, Patel, Vyomesh, Gutkind, J Silvio, Rivadulla, Maria G, Curino, Alejandro C

“…Sphingosine kinase-1 (SPHK1) modulates the proliferation, apoptosis and differentiation of keratinocytes through the regulation of ceramide and…”
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Heme oxygenase-1 expression in human gliomas and its correlation with poor prognosis in patients with astrocytoma by Gandini, Norberto A., Fermento, María E., Salomón, Débora G., Obiol, Diego J., Andrés, Nancy C., Zenklusen, Jean C., Arevalo, Julián, Blasco, Jorge, López Romero, Alejandro, Facchinetti, María M., Curino, Alejandro C.

“…In human glioma tumors, heme oxygenase-1 (HO-1) has been shown to be upregulated both when compared with normal brain tissues and also during oligodendroglioma…”
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Mammary differentiation induces expression of Tristetraprolin, a tumor suppressor AU-rich mRNA-binding protein by Goddio, M. Victoria, Gattelli, Albana, Slomiansky, Victoria, Lacunza, Ezequiel, Gingerich, Timothy, Tocci, Johanna M., Facchinetti, María M., Curino, Alejandro C., LaMarre, Jonathan, Abba, Martín C., Kordon, Edith C.

“…Tristetraprolin (TTP) is a RNA-binding protein that inhibits the expression of pro-inflammatory cytokines and invasiveness-associated genes. TTP levels are…”
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The alkynylphosphonate analogue of calcitriol EM1 has potent anti-metastatic effects in breast cancer by Ferronato, María J., Obiol, Diego J., Fermento, María E., Gandini, Norberto A., Alonso, Eliana N., Salomón, Débora G., Vitale, Cristian, Mascaró, Evangelina, Fall, Yagamare, Raimondi, Ana R., Curino, Alejandro C., Facchinetti, María M.

“…[Display omitted] •EM1 reduces the number of lung metastases in an animal model of breast cancer.•EM1 inhibits cellular migration and invasion in a breast…”
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Novel Alkynylphosphonate Analogue of Calcitriol with Potent Antiproliferative Effects in Cancer Cells and Lack of Calcemic Activity by Salomón, Débora G, Grioli, Silvina M, Buschiazzo, Maximiliano, Mascaró, Evangelina, Vitale, Cristian, Radivoy, Gabriel, Perez, Manuel, Fall, Yagamare, Mesri, Enrique A, Curino, Alejandro C, Facchinetti, María M

“…Here, we describe the design and synthesis of diethyl [(5Z,7E)-(1S,3R)-1,3-dihydroxy-9,10-secochola-5,7,10(19)-trien-23-in-24-yl] phosphonate (compound 10),…”
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Intracellular distribution of p300 and its differential recruitment to aggresomes in breast cancer by FERMENTO, Maria E, GANDINI, Norberto A, LANG, Cecilia A, PEREZ, Juan E, MATURI, Horacio V, CURINO, Alejandro C, FACCHINETTI, Maria M

“…It has been recently suggested that p300 cytoplasmic redistribution and degradation are important for controlling the availability and activity of the protein…”
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Synthesis and biological evaluation of a new vitamin D2 analogue by Gándara, Zoila, Pérez, Manuel, Salomón, Débora G., Ferronato, María J., Fermento, María E., Curino, Alejandro C., Facchinetti, María M., Gómez, Generosa, Fall, Yagamare

“…A new vitamin D2 analogue was synthesized using the Julia–Kocienski olefination. It has antiproliferative effects on cell lines from squamous cell carcinomas…”
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Vitamin D receptor exhibits different pharmacodynamic features in tumoral and normal microenvironments: A molecular modeling study by Ribone, Sergio R., Ferronato, Maria J., Vitale, Cristian, Fall, Yagamare, Curino, Alejandro C., Facchinetti, Maria M., Quevedo, Mario A.

“…[Display omitted] •VDR receptor exhibit different pharmacodinamic states under neutral and acidic environments.•The selectivity for tumoral cells of VDR…”
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Stratification of sphingosine kinase-1 expression and activity in rat kidney by Facchinetti, Maria M, Leocata Nieto, Francisco, Márquez, Maria G, Sterin-Speziale, Norma

“…Sphingosine-1-phosphate, the product of sphingosine kinase (SK) activity, is a sphingolipid metabolite that regulates cell growth, survival and migration. It…”
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Structural analysis and biological activities of C25-amino and C25-nitro vitamin D analogs by Gómez-Bouzó, Uxía, Belorusova, Anna Y., Rivadulla, Marcos L., Santalla, Hugo, Verlinden, Lieve, Verstuyf, Annemieke, Ferronato, Maria J, Curino, Alejandro C., Facchinetti, Maria M., Fall, Yagamare, Gómez, Generosa, Rochel, Natacha

“…[Display omitted] ••Structural analysis of 25-nitro derivative (2) and 25-amino derivative (3) of 1,25-dihydroxyvitamin D3 in complex with zVDR ligand binding…”
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UCN-01-induced cell cycle arrest requires the transcriptional induction of p21(waf1/cip1) by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway by Facchinetti, Maria M, De Siervi, Adriana, Toskos, Doreen, Senderowicz, Adrian M

“…The small molecule UCN-01 is a cyclin-dependent kinase (CDK) modulator shown to have antiproliferative effects against several in vitro and in vivo cancer…”
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Phenoxodiol, a novel isoflavone, induces G1 arrest by specific loss in cyclin-dependent kinase 2 activity by p53-independent induction of p21WAF1/CIP1 by Aguero, Martin F, Facchinetti, Maria M, Sheleg, Zhanna, Senderowicz, Adrian M

“…Phenoxodiol, an isoflavone derivative of genistein with unknown mechanism of action, is currently being evaluated in early human cancer clinical trials. To…”
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UCN-01-induced cell cycle arrest requires the transcriptional induction of p21waf1/cip1 by activation of mitogen-activated protein/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase pathway by FACCHINETTI, Maria M, DE SIERVI, Adriana, TOSKOS, Doreen, SENDEROWICZ, Adrian M

“…Abstract The small molecule UCN-01 is a cyclin-dependent kinase (CDK) modulator shown to have antiproliferative effects against several in vitro and in vivo…”
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RETRACTED: Intracellular distribution of p300 and its differential recruitment to aggresomes in breast cancer by Fermento, María E., Gandini, Norberto A., Lang, Cecilia A., Perez, Juan E., Maturi, Horacio V., Curino, Alejandro C., Facchinetti, María M.

“…This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been…”
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