Search Results - "Facchin, Gianella"

New Copper(II)-L-Dipeptide-Bathophenanthroline Complexes as Potential Anticancer Agents-Synthesis, Characterization and Cytotoxicity Studies-And Comparative DNA-Binding Study of Related Phen Complexes by Fernández, Carlos Y, Alvarez, Natalia, Rocha, Analu, Ellena, Javier, Costa-Filho, Antonio J, Batista, Alzir A, Facchin, Gianella

“…Searching for new copper compounds which may be useful as antitumor drugs, a series of new [Cu(L-dipeptide)(batho)] (batho:4,7-diphenyl-1,10-phenanthroline,…”
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Comparative Study of Antioxidant and Pro-Oxidant Properties of Homoleptic and Heteroleptic Copper Complexes with Amino Acids, Dipeptides and 1,10-Phenanthroline: The Quest for Antitumor Compounds by Veiga, Nicolás, Alvarez, Natalia, Castellano, Eduardo E, Ellena, Javier, Facchin, Gianella, Torre, María H

“…In a search for new antitumoral agents, a series of homoleptic copper(II) complexes with amino acids and dipeptides, as well as heteroleptic complexes…”
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Tetramethyl-phenanthroline copper complexes in the development of drugs to treat cancer: synthesis, characterization and cytotoxicity studies of a series of copper(II)-l-dipeptide-3,4,7,8-tetramethyl-phenanthroline complexes by Alvarez, Natalia, Leite, Celisnolia M., Napoleone, Adriana, Mendes, Luis F. S., Fernández, Carlos Y., Ribeiro, Ronny R., Ellena, Javier, Batista, Alzir A., Costa-Filho, Antonio J., Facchin, Gianella

“…New compounds to fight cancer are needed due to cancer high incidence and lack of curative treatments for several classes of this disease. Metal-based…”
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New Insights into the Biophysical Behavior of an Old Molecule: Experimental and Theoretical Studies of the Interaction Between 1,10-Phenanthroline and Model Phospholipid Membranes by Alvarez, Natalia, Freddi, Priscilla, Castellani, Stephanie, Veiga, Nicolás, Facchin, Gianella, Costa-Filho, Antonio J.

“…1,10-Phenanthroline, phen, is a molecule with a wide variety of chemical and biological activities, being interesting from a pharmacological standpoint. Its…”
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Bioinorganic Chemistry of Copper: From Biochemistry to Pharmacology by Da Costa Ferreira, Ana Maria, Hureau, Christelle, Facchin, Gianella

“…Copper is an essential trace element found ubiquitously in humans [...]…”
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Development of Copper Complexes with Diimines and Dipicolinate as Anticancer Cytotoxic Agents by Alvarez, Natalia, Rocha, Analu, Collazo, Victoria, Ellena, Javier, Costa-Filho, Antonio J, Batista, Alzir A, Facchin, Gianella

“…Coordination complexes may act as anticancer agents. Among others, the formation of the complex may facilitate the ligand uptake by the cell. Searching for new…”
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Synthesis, Characterization, DNA Binding and Cytotoxicity of Copper(II) Phenylcarboxylate Complexes by Fernández, Carlos Y, Rocha, Analu, Azam, Mohammad, Alvarez, Natalia, Min, Kim, Batista, Alzir A, Costa-Filho, Antonio J, Ellena, Javier, Facchin, Gianella

“…Coordination compounds of copper exhibit cytotoxic activity and are suitable for the search for novel drug candidates for cancer treatment. In this work, we…”
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Synthesis, structural characterization and DNA interaction of new copper-terpyridine complexes by Alvarez, Natalia, Veiga, Nicolás, Iglesias, Sebastián, Torre, María H., Facchin, Gianella

“…Two new Cu-terpy complexes were characterized by X-ray diffraction. By means of theoretical calculations the IR spectra is interpreted in detail. Docking…”
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High-dose selenium for critically ill patients with systemic inflammation: Pharmacokinetics and pharmacodynamics of selenious acid: A pilot study by Manzanares, William, M.D, Biestro, Alberto, M.D, Galusso, Federico, M.D, Torre, María H., Ph.D, Mañáy, Nelly, Ph.D, Facchin, Gianella, Ph.D, Hardy, Gil, Ph.D

“…Abstract Objective Systemic inflammatory response syndrome is characterized by increased urinary excretion of selenium and low serum concentration. Repletion…”
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Intermolecular interaction analysis from SCXRD and their relationship with observed properties in potential pharmaceuticals by Alvarez, Natalia, Costa-Filho, Antonio José, Ellena, Javier, Facchin, Gianella

“…Abstract only…”
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Development of copper(II)-diimine-iminodiacetate mixed ligand complexes as potential antitumor agents by Alvarez, Natalia, Mendes, Luis F.S., Kramer, M. Gabriela, Torre, María H., Costa-Filho, Antonio J., Ellena, Javier, Facchin, Gianella

“…Cu-iminodiacetate-diimine complexes were studied. They were characterized in solid state, including new crystalline structures, and in aqueous solution. Its…”
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Phenanthroline and phenyl carboxylate mixed ligand copper complexes in developing drugs to treat cancer by Fernández, Carlos Y., Alvarez, Natalia, Rocha, Analu, Mendes, Luis Felipe S., Costa-Filho, Antonio J., Ellena, Javier, Batista, Alzir A., Facchin, Gianella

“…The success of a classic inorganic coordination compound, Cisplatin, cis-[Pt(NH3)2Cl2], as the first anticancer metallodrug started a field of research…”
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Synthesis and structural characterization of a series of ternary copper(II)-L-dipeptide-neocuproine complexes. Study of their cytotoxicity against cancer cells including MDA-MB-231, triple negative breast cancer cells by Alvarez, Natalia, Viña, Diana, Leite, Celisnolia M., Mendes, Luis F.S., Batista, Alzir A., Ellena, Javier, Costa-Filho, Antonio J., Facchin, Gianella

“…This work presents the synthesis and characterization of eight copper complexes [Cu(L-dipeptide)(neo)]·nH2O (neo = neocuproine) and their cytotoxic activities…”
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Novel bisthiazole ligand and its copper(II) complex with unusual seven membered ring: Synthesis, characterization, experimental and theoretical study of the effect of ligand flexibility, and antimicrobial activity by Velluti, Francesca, Acevedo, Ana, Serra, Gloria, Ellena, Javier, Borthagaray, Graciela, Facchin, Gianella, Scarone, Laura, Alvarez, Natalia, Torre, María H.

“…A novel bisthiazole ligand and its copper(II) complex were synthetized. Single crystal X-ray diffraction of complex evidence a pentacoordinated copper center…”
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High-dose selenium reduces ventilator-associated pneumonia and illness severity in critically ill patients with systemic inflammation by Manzanares, William, Biestro, Alberto, Torre, María H., Galusso, Federico, Facchin, Gianella, Hardy, Gil

“…Purpose To confirm the pharmacodynamics and evaluate the efficacy of high-dose selenium (Se) administered by continuous infusion, following an initial loading…”
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Serum selenium and glutathione peroxidase-3 activity: biomarkers of systemic inflammation in the critically ill? by Manzanares, William, Biestro, Alberto, Galusso, Federico, Torre, Maria H., Mañay, Nelly, Pittini, Gustavo, Facchin, Gianella, Hardy, Gil

“…Objectives To confirm the influence of systemic inflammatory response syndrome (SIRS) on selenium (Se) levels and prospectively evaluate the relationship…”
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New BI and TRI-Thiazole copper (II) complexes in the search of new cytotoxic drugs against breast cancer cells by Alvarez, Natalia, Velluti, Francesca, Guidali, Florencia, Serra, Gloria, Gabriela Kramer, M., Ellena, Javier, Facchin, Gianella, Scarone, Laura, Torre, María H.

“…[Display omitted] •Two new bi and tri thiazolyl derivatives were synthesized and characterized.•The corresponding Cu(II) complexes were synthesized and…”
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Experimental and theoretical studies of copper complexes with isomeric dipeptides as novel candidates against breast cancer by Facchin, Gianella, Veiga, Nicolás, Kramer, M. Gabriela, Batista, Alzir A., Várnagy, Katalin, Farkas, Etelka, Moreno, Virtudes, Torre, María H.

“…In the search for new cytotoxic drugs, two copper complexes with isomeric dipeptides (Ala-Phe and Phe-Ala) were developed in order to determine the influence…”
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Synthesis, structural characterization and cytotoxic activity of ternary copper(II)–dipeptide–phenanthroline complexes. A step towards the development of new copper compounds for the treatment of cancer by Iglesias, Sebastián, Alvarez, Natalia, Torre, María H., Kremer, Eduardo, Ellena, Javier, Ribeiro, Ronny R., Barroso, Rafael P., Costa-Filho, Antonio J., Kramer, M. Gabriela, Facchin, Gianella

“…In the search for new compounds with antitumor activity, coordination complexes with different metals are being studied by our group. This work presents the…”
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Study of a series of cobalt(II) sulfonamide complexes: Synthesis, spectroscopic characterization, and microbiological evaluation against M. tuberculosis. Crystal structure of [Co(sulfamethoxazole)2(H2O)2]·H2O by Mondelli, Melina, Pavan, Fernando, de Souza, Paula C., Leite, Clarice Q., Ellena, Javier, Nascimento, Otaciro R., Facchin, Gianella, Torre, María H.

“…► We synthesized Co(II) complexes with general formulae [Co(sulfonamide)2]·nH2O. ► IR, UV–Vis and EPR spectra showed different coordination depending on the…”
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