Search Results - "Fabrizio, P"
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1
Exuberant fibroblast activity compromises lung function via ADAMTS4
Published in Nature (London) (19-11-2020)“…Severe respiratory infections can result in acute respiratory distress syndrome (ARDS) 1 . There are no effective pharmacological therapies that have been…”
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2
Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites
Published in European journal of medicinal chemistry (05-11-2018)“…The 2-phenylbenzimidazole scaffold has recently been discovered to inhibit β-hematin (synthetic hemozoin) formation by high throughput screening. Here, a…”
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3
Molecular requirements for a pandemic influenza virus: An acid-stable hemagglutinin protein
Published in Proceedings of the National Academy of Sciences - PNAS (09-02-2016)“…Influenza pandemics require that a virus containing a hemagglutinin (HA) surface antigen previously unseen by a majority of the population becomes…”
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4
Early transcranial direct current stimulation with modified constraint-induced movement therapy for motor and functional upper limb recovery in hospitalized patients with stroke: A randomized, multicentre, double-blind, clinical trial
Published in Brain stimulation (01-01-2023)“…Constraint-induced movement therapy (CIMT) and transcranial direct current stimulation (tDCS) are used to reduce interhemispheric imbalance after stroke, which…”
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5
Visualization of murine intranasal dosing efficiency using luminescent Francisella tularensis: effect of instillation volume and form of anesthesia
Published in PloS one (24-02-2012)“…Intranasal instillation is a widely used procedure for pneumonic delivery of drugs, vaccine candidates, or infectious agents into the respiratory tract of…”
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6
Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor
Published in Proceedings of the National Academy of Sciences - PNAS (29-03-2016)“…The influenza endonuclease is an essential subdomain of the viral RNA polymerase. It processes host pre-mRNAs to serve as primers for viral mRNA and is an…”
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Epigenetic versus Genetic Deregulation of the KEAP1/NRF2 Axis in Solid Tumors: Focus on Methylation and Noncoding RNAs
Published in Oxidative medicine and cellular longevity (01-01-2018)“…Oxidative and electrophilic changes in cells are mainly coordinated by the KEAP1/NRF2 (Kelch-like erythroid-derived cap-n-collar homology- (ECH-) associated…”
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8
NRG1-ErbB Lost in Translation: A New Paradigm for Lung Cancer?
Published in Current medicinal chemistry (01-11-2017)“…Molecular lesions of the NRG1 gene were recently described as a new molecular feature of Invasive Mucinous Adenocarcinoma of the lung. The NRG1 chimeric ligand…”
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Visions & Reflections¶Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans?
Published in Cellular and molecular life sciences : CMLS (01-06-2002)“…Recent studies implicate similar proteins in the regulation of longevity in organisms ranging from yeast to mice. Studies in yeast and worms suggest that…”
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10
Regulation of longevity and stress resistance: a molecular strategy conserved from yeast to humans?
Published in Cellular and molecular life sciences : CMLS (01-06-2002)“…Recent studies implicate similar proteins in the regulation of longevity in organisms ranging from yeast to mice. Studies in yeast and worms suggest that…”
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11
Chronological aging-independent replicative life span regulation by Msn2/Msn4 and Sod2 in Saccharomyces cerevisiae
Published in FEBS letters (16-01-2004)“…Mutations in RAS2, CYR1, and SCH9 extend the chronological life span in Saccharomyces cerevisiae by activating stress-resistance transcription factors and…”
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Regulation of Longevity and Stress Resistance by Sch9 in Yeast
Published in Science (American Association for the Advancement of Science) (13-04-2001)“…The protein kinase Akt/protein kinase B (PKB) is implicated in insulin signaling in mammals and functions in a pathway that regulates longevity and stress…”
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13
Adaptation of pandemic H2N2 influenza A viruses in humans
Published in Journal of virology (01-02-2015)“…The 1957 A/H2N2 influenza virus caused an estimated 2 million fatalities during the pandemic. Since viruses of the H2 subtype continue to infect avian species…”
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14
Pathogenicity and transmissibility of North American triple reassortant swine influenza A viruses in ferrets
Published in PLoS pathogens (01-07-2012)“…North American triple reassortant swine (TRS) influenza A viruses have caused sporadic human infections since 2005, but human-to-human transmission has not…”
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15
Antibody Responses to SARS-CoV-2 Antigens in Humans and Animals
Published in Vaccines (Basel) (16-11-2020)“…To optimize the public health response to coronavirus disease 2019 (COVID-19), we must first understand the antibody response to individual proteins on the…”
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Infection and Vaccine-Induced Neutralizing-Antibody Responses to the SARS-CoV-2 B.1.617 Variants
Published in The New England journal of medicine (12-08-2021)“…Among samples obtained from persons who had received the mRNA-1273 or BNT162b2 vaccines, neutralizing antibody titers against the B.1.617.1 variant were 6.8…”
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Effects of pesticides commonly used in peach orchards in Brazil on predatory lacewing Chrysoperla carnea under laboratory conditions
Published in BioControl (Dordrecht, Netherlands) (01-10-2009)“…Effects of the maximum field recommended concentration of five pesticides currently used on peaches in Brazil; abamectin, deltamethrin, methoxyfenozide,…”
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Putative amino acid determinants of the emergence of the 2009 influenza A (H1N1) virus in the human population
Published in Proceedings of the National Academy of Sciences - PNAS (16-08-2011)“…The emergence of the unique H1N1 influenza A virus in 2009 resulted in a pandemic that has spread to over 200 countries. The constellation of molecular factors…”
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SARS-CoV-2 antigen exposure history shapes phenotypes and specificity of memory CD8+ T cells
Published in Nature immunology (01-05-2022)“…Although mRNA vaccine efficacy against severe coronavirus disease 2019 remains high, variant emergence has prompted booster immunizations. However, the effects…”
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A simple model system for age-dependent DNA damage and cancer
Published in Mechanisms of ageing and development (01-01-2007)“…Aging is the major risk factor for many human cancers. However, the mechanisms responsible for the effect of aging on tumor incidence are poorly understood, in…”
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