Search Results - "Fabri, Louis"

The core domain of hepatitis C virus glycoprotein E2 generates potent cross‐neutralizing antibodies in guinea pigs by Vietheer, Patricia T., Boo, Irene, Gu, Jun, McCaffrey, Kathleen, Edwards, Stirling, Owczarek, Catherine, Hardy, Matthew P., Fabri, Louis, Center, Rob J., Poumbourios, Pantelis, Drummer, Heidi E.

“…A vaccine that prevents hepatitis C virus (HCV) infection is urgently needed to support an emerging global elimination program. However, vaccine development…”
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Engineering Stabilized Vascular Endothelial Growth Factor-A Antagonists: Synthesis, Structural Characterization, and Bioactivity of Grafted Analogues of Cyclotides by Gunasekera, Sunithi, Foley, Fiona M, Clark, Richard J, Sando, Lillian, Fabri, Louis J, Craik, David J, Daly, Norelle L

“…Cyclotides are plant derived mini-proteins with compact folded structures and exceptional stability. Their stability derives from a head-to-tail cyclized…”
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Scalability of Sartobind® Rapid A Membrane for High Productivity Monoclonal Antibody Capture by Yang, Sabrina, Braczkowski, Ryszard, Chen, Shih-Hsun, Busse, Ricarda, Li, Yudhi, Fabri, Louis, Bekard, Innocent Berbelle

“…Improved upstream titres in therapeutic monoclonal antibody (mAb) production have shifted capacity constraints to the downstream process. The consideration of…”
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One-step zero-background IgG reformatting of phage-displayed antibody fragments enabling rapid and high-throughput lead identification by Chen, Chao-Guang, Fabri, Louis J, Wilson, Michael J, Panousis, Con

“…We describe a novel cloning method, referred to as insert-tagged (InTag) positive selection, for the rapid one-step reformatting of phage-displayed antibody…”
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EphA4 receptor tyrosine kinase is a modulator of onset and disease severity of experimental autoimmune encephalomyelitis (EAE) by Munro, Kathryn M, Dixon, Kirsty J, Gresle, Melissa M, Jonas, Anna, Kemper, Dennis, Doherty, William, Fabri, Louis J, Owczarek, Catherine M, Pearse, Martin, Boyd, Andrew W, Kilpatrick, Trevor J, Butzkueven, Helmut, Turnley, Ann M

“…The EphA4 receptor tyrosine kinase is a major regulator of axonal growth and astrocyte reactivity and is a possible inflammatory mediator. Given that multiple…”
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A robust robotic high-throughput antibody purification platform by Schmidt, Peter M., Abdo, Michael, Butcher, Rebecca E., Yap, Min-Yin, Scotney, Pierre D., Ramunno, Melanie L., Martin-Roussety, Genevieve, Owczarek, Catherine, Hardy, Matthew P., Chen, Chao-Guang, Fabri, Louis J.

“…•Two stage robust antibody purification platform has been established.•High yield preparative antibody purification for initial screening…”
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Optimizing high throughput antibody purification by using continuous chromatography media by Butcher, Rebecca E., Martin-Roussety, Genevieve, Bradford, Rebecca A., Tester, Andrea, Owczarek, Catherine, Hardy, Matthew P., Chen, Chao-Guang, Sansome, Georgina, Fabri, Louis J., Schmidt, Peter M.

“…The ability to engineer monoclonal antibodies (mAbs) with high specificity made mAbs the fastest growing segment in the drug market. mAbs represent 8 of the…”
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CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common β chain of the IL-3, GM-CSF and IL-5 receptors by Panousis, Con, Dhagat, Urmi, Edwards, Kirsten M, Rayzman, Veronika, Hardy, Matthew P, Braley, Hal, Gauvreau, Gail M, Hercus, Timothy R, Smith, Steven, Sehmi, Roma, McMillan, Laura, Dottore, Mara, McClure, Barbara J, Fabri, Louis J, Vairo, Gino, Lopez, Angel F, Parker, Michael W, Nash, Andrew D, Wilson, Nicholas J, Wilson, Michael J, Owczarek, Catherine M

“…The β common-signaling cytokines interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF) and IL-5 stimulate pro-inflammatory activities…”
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Suppressor of Cytokine Signaling-3 Preferentially Binds to the SHP-2-Binding Site on the Shared Cytokine Receptor Subunit gp130 by Nicholson, Sandra E., De Souza, David, Fabri, Louis J., Corbin, Jason, Willson, Tracy A., Zhang, Jian-Guo, Silva, Anabel, Asimakis, Maria, Farley, Alison, Nash, Andrew D., Metcalf, Donald, Hilton, Douglas J., Nicola, Nicos A., Baca, Manuel

“…Suppressor of cytokine signaling-3 (SOCS-3) is one member of a family of intracellular inhibitors of signaling pathways initiated by cytokines that use, among…”
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SOCS2 negatively regulates growth hormone action in vitro and in vivo by Greenhalgh, Christopher J, Rico-Bautista, Elizabeth, Lorentzon, Mattias, Thaus, Anne L, Morgan, Phillip O, Willson, Tracy A, Zervoudakis, Panagiota, Metcalf, Donald, Street, Ian, Nicola, Nicos A, Nash, Andrew D, Fabri, Louis J, Norstedt, Gunnar, Ohlsson, Claes, Flores-Morales, Amilcar, Alexander, Warren S, Hilton, Douglas J

“…Mice deficient in SOCS2 display an excessive growth phenotype characterized by a 30-50% increase in mature body size. Here we show that the SOCS2-/- phenotype…”
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Production of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1 by Redpath, Nicholas T, Xu, Yibin, Wilson, Nicholas J, Fabri, Louis J, Baca, Manuel, Andrews, Arna E, Braley, Hal, Lu, Ping, Ireland, Cheryl, Ernst, Robin E, Woods, Andrea, Forrest, Gail, An, Zhiqiang, Zaller, Dennis M, Strohl, William R, Luo, Cindy S, Czabotar, Peter E, Garrett, Thomas P J, Hilton, Douglas J, Nash, Andrew D, Zhang, Jian-Guo, Nicola, Nicos A

“…Gene deletion studies in mice have revealed critical roles for IL (interleukin)-4 and -13 in asthma development, with the latter controlling lung airways…”
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Intravenous immunglobulin binds beta amyloid and modifies its aggregation, neurotoxicity and microglial phagocytosis in vitro by Cattepoel, Susann, Schaub, Alexander, Ender, Miriam, Gaida, Annette, Kropf, Alain, Guggisberg, Ursula, Nolte, Marc W, Fabri, Louis, Adlard, Paul A, Finkelstein, David I, Bolli, Reinhard, Miescher, Sylvia M

“…Intravenous Immunoglobulin (IVIG) has been proposed as a potential therapeutic for Alzheimer's disease (AD) and its efficacy is currently being tested in…”
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Biological Evidence That SOCS-2 Can Act Either as an Enhancer or Suppressor of Growth Hormone Signaling by Greenhalgh, Christopher J, Metcalf, Donald, Thaus, Anne L, Corbin, Jason E, Uren, Rachel, Morgan, Phillip O, Fabri, Louis J, Zhang, Jian-Guo, Martin, Helene M, Willson, Tracy A, Billestrup, Nils, Nicola, Nicos A, Baca, Manuel, Alexander, Warren S, Hilton, Douglas J

“…Suppressor of cytokine signaling (SOCS)-2 is a member of a family of intracellular proteins implicated in the negative regulation of cytokine signaling. The…”
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SH2 Domains from Suppressor of Cytokine Signaling-3 and Protein Tyrosine Phosphatase SHP-2 Have Similar Binding Specificities by De Souza, David, Fabri, Louis J, Nash, Andrew, Hilton, Douglas J, Nicola, Nicos A, Baca, Manuel

“…Suppressor of cytokine signaling-3 (SOCS-3) and the protein tyrosine phosphatase SHP-2 both regulate signaling by cytokines of the interleukin-6 family, and…”
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SOCS2 negatively regulates growth hormone action in vitro and in vivo by Greenhalgh, Christopher J., Rico-Bautista, Elizabeth, Lorentzon, Mattias, Thaus, Anne L., Morgan, Phillip O., Willson, Tracy A., Zervoudakis, Panagiota, Metcalf, Donald, Street, Ian, Nicola, Nicos A., Nash, Andrew D., Fabri, Louis J., Norstedt, Gunnar, Ohlsson, Claes, Flores-Morales, Amilcar, Alexander, Warren S., Hilton, Douglas J.

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Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralising Antibody Fab Fragment by Leonard, Philip, Scotney, Pierre D., Jabeen, Talat, Iyer, Shalini, Fabri, Louis J., Nash, Andrew D., Acharya, K. Ravi

“…Vascular endothelial growth factor (VEGF) B effects blood vessel formation by binding to VEGF receptor 1. To study the specifics of the biological profile of…”
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Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain by Babon, Jeffrey J., Yao, Shenggen, DeSouza, David P., Harrison, Christopher F., Fabri, Louis J., Liepinsh, Edvards, Scrofani, Sergio D., Baca, Manuel, Norton, Raymond S.

“…SOCS3 is a negative regulator of cytokine signalling that inhibits Janus kinase‐signal transduction and activator of transcription (JAK‐STAT) mediated signal…”
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Crystallization and preliminary X-ray diffraction analysis of the interleukin-3 alpha receptor bound to the Fab fragment of antibody CSL362 by Broughton, Sophie E., Hercus, Timothy R., Nero, Tracy L., Dhagat, Urmi, Owczarek, Catherine M., Hardy, Matthew P., Fabri, Louis J., Scotney, Pierre D., Nash, Andrew D., Wilson, Nicholas J., Lopez, Angel F., Parker, Michael W.

“…Interleukin‐3 (IL‐3) is a member of the beta common family of cytokines that regulate multiple functions of myeloid cells. The IL‐3 receptor‐specific alpha…”
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Endogenous IL-11 Signaling Is Essential in Th2- and IL-13-Induced Inflammation and Mucus Production by Lee, Chun Geun, Hartl, Dominik, Matsuura, Hiroshi, Dunlop, Felicity M, Scotney, Pierre D, Fabri, Louis J, Nash, Andrew D, Chen, Ning-Yuan, Tang, Chu-Yan, Chen, Qingsheng, Homer, Robert J, Baca, Manuel, Elias, Jack A

“…IL-11 and IL-11 receptor (R)alpha are induced by Th2 cytokines. However, the role(s) of endogenous IL-11 in antigen-induced Th2 inflammation has not been fully…”
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Application of mechanistic modelling in membrane and fiber chromatography for purification of biotherapeutics — A review by Qu, Yiran, Baker, Irene, Black, Jamie, Fabri, Louis, Gras, Sally L., Lenhoff, Abraham M., Kentish, Sandra E.

“…•Mass transfer models for membrane and fiber chromatography are described.•Models can be less complicated than for resin chromatography.•Different flow paths…”
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