Search Results - "Fabres, Carla Cofiño"

Multimodal Mapping of Electrical and Mechanical Latency of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Layers by Zhang, Xinyu, Burattini, Margherita, Duru, Jens, Chala, Nafsika, Wyssen, Nino, Cofiño-Fabres, Carla, Rivera-Arbeláez, José Manuel, Passier, Robert, Poulikakos, Dimos, Ferrari, Aldo, Tringides, Christina, Vörös, János, Luciani, Giovanni Battista, Miragoli, Michele, Zambelli, Tomaso

“…The synchronization of the electrical and mechanical coupling assures the physiological pump function of the heart, but life-threatening pathologies may…”
Get full text

Micro‐Engineered Heart Tissues On‐Chip with Heterotypic Cell Composition Display Self‐Organization and Improved Cardiac Function by Cofiño‐Fabres, Carla, Boonen, Tom, Rivera‐Arbeláez, José M., Rijpkema, Minke, Blauw, Lisanne, Rensen, Patrick C. N., Schwach, Verena, Ribeiro, Marcelo C., Passier, Robert

“…Advanced in vitro models that recapitulate the structural organization and function of the human heart are highly needed for accurate disease modeling, more…”
Get full text

Towards Improved Human In Vitro Models for Cardiac Arrhythmia: Disease Mechanisms, Treatment, and Models of Atrial Fibrillation by Cofiño-Fabres, Carla, Passier, Robert, Schwach, Verena

“…Heart rhythm disorders, arrhythmias, place a huge economic burden on society and have a large impact on the quality of life of a vast number of people…”
Get full text

Automated assessment of human engineered heart tissues using deep learning and template matching for segmentation and tracking by Rivera‐Arbeláez, José M., Keekstra, Danjel, Cofiño‐Fabres, Carla, Boonen, Tom, Dostanic, Milica, Den, Simone A., Vermeul, Kim, Mastrangeli, Massimo, Berg, Albert, Segerink, Loes I., Ribeiro, Marcelo C., Strisciuglio, Nicola, Passier, Robert

“…The high rate of drug withdrawal from the market due to cardiovascular toxicity or lack of efficacy, the economic burden, and extremely long time before a…”
Get full text

A safety screening platform for individualized cardiotoxicity assessment by Schwach, Verena, Slaats, Rolf H., Cofiño-Fabres, Carla, ten Den, Simone A., Rivera-Arbeláez, José M., Dannenberg, Maureen, van Boheemen, Chiara, Ribeiro, Marcelo C., van der Zanden, Sabina Y., Nollet, Edgar E., van der Velden, Jolanda, Neefjes, Jacques, Cao, Lu, Passier, Robert

“…Cardiotoxicity remains a major cause of drug withdrawal, partially due to lacking predictability of animal models. Additionally, risk of cardiotoxicity…”
Get full text

Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation by Harlaar, Niels, Dekker, Sven O., Zhang, Juan, Snabel, Rebecca R., Veldkamp, Marieke W., Verkerk, Arie O., Fabres, Carla Cofiño, Schwach, Verena, Lerink, Lente J. S., Rivaud, Mathilde R., Mulder, Aat A., Corver, Willem E., Goumans, Marie José T. H., Dobrev, Dobromir, Klautz, Robert J. M., Schalij, Martin J., Veenstra, Gert Jan C., Passier, Robert, van Brakel, Thomas J., Pijnappels, Daniël A., de Vries, Antoine A. F.

“…The lack of a scalable and robust source of well-differentiated human atrial myocytes constrains the development of in vitro models of atrial fibrillation…”
Get full text

Upscaling Osteoclast Generation by Enhancing Macrophage Aggregation Using Hollow Microgels by Husch, Johanna F.A., Araújo‐Gomes, Nuno, Willemen, Niels G.A., Cofiño‐Fabrés, Carla, van Creij, Nils, Passier, Robert, Leijten, Jeroen, van den Beucken, Jeroen J. J. P.

“…Osteoclasts, the bone resorbing cells of hematopoietic origin formed by macrophage fusion, are essential in bone health and disease. However, in vitro research…”
Get full text

Contractility analysis of human engineered 3D heart tissues by an automatic tracking technique using a standalone application by Rivera-Arbeláez, José M, Cofiño-Fabres, Carla, Schwach, Verena, Boonen, Tom, Ten Den, Simone A, Vermeul, Kim, van den Berg, Albert, Segerink, Loes I, Ribeiro, Marcelo C, Passier, Robert

“…The use of Engineered Heart Tissues (EHT) as in vitro model for disease modeling and drug screening has increased, as they provide important insight into the…”
Get full text

Improved Atrial Differentiation of Human Pluripotent Stem Cells by Activation of Retinoic Acid Receptor Alpha (RARα) by Schwach, Verena, Cofiño-Fabres, Carla, Ten Den, Simone A, Passier, Robert

“…Human pluripotent stem cell (hPSC)-derived cardiomyocytes have proven valuable for modeling disease and as a drug screening platform. Here, we depict an…”
Get full text

A New Versatile Platform for Assessment of Improved Cardiac Performance in Human-Engineered Heart Tissues by Ribeiro, Marcelo C, Rivera-Arbeláez, José M, Cofiño-Fabres, Carla, Schwach, Verena, Slaats, Rolf H, Ten Den, Simone A, Vermeul, Kim, van den Berg, Albert, Pérez-Pomares, José M, Segerink, Loes I, Guadix, Juan A, Passier, Robert

“…Cardiomyocytes derived from human pluripotent stem cells (hPSC-CMs) hold a great potential as human in vitro models for studying heart disease and for drug…”
Get full text

Towards Improved Human IIn Vitro/I Models for Cardiac Arrhythmia: Disease Mechanisms, Treatment, and Models of Atrial Fibrillation by Cofiño-Fabres, Carla, Passier, Robert, Schwach, Verena

“…Heart rhythm disorders, arrhythmias, place a huge economic burden on society and have a large impact on the quality of life of a vast number of people…”
Get full text

The Effects Of In Vitro Exercise Of Engineered Heart Tissues On Cardiac Injury And Function: 721 by Luiken, Tom T. J., Cofiño-Fabres, Carla, Rivera-Arbeláez, José M., Snippert, Danique, Denessen, Ellen J. S., Mingels, Alma M. A., Thijssen, Dick H. J., Passier, Robert C. J. J., Eijsvogels, Thijs M. H.

Get full text

Micro‐Engineered Heart Tissues On‐Chip with Heterotypic Cell Composition Display Self‐Organization and Improved Cardiac Function (Adv. Healthcare Mater. 18/2024) by Cofiño‐Fabres, Carla, Boonen, Tom, Rivera‐Arbeláez, José M., Rijpkema, Minke, Blauw, Lisanne, Rensen, Patrick C. N., Schwach, Verena, Ribeiro, Marcelo C., Passier, Robert

“…Self‐Organized Micro‐Engineered Heart Tissues‐On‐A‐Chip In article 2303664 by Robert Passier and co‐workers, an innovative heart‐on‐a‐chip platform featuring…”
Get full text

Contractility analysis of human engineered 3D heart tissues by an automatic tracking technique using a standalone application by José M. Rivera-Arbeláez, Carla Cofiño-Fabres, Verena Schwach, Tom Boonen, Simone A. ten Den, Kim Vermeul, Albert van den Berg, Loes I. Segerink, Marcelo C. Ribeiro, Robert Passier

“…The use of Engineered Heart Tissues (EHT) as in vitro model for disease modeling and drug screening has increased, as they provide important insight into the…”
Get full text

Abstract 13272: Modeling Cardiotoxicity Utilizing Human Pluripotent Stem Cell-Derived Cardiomyocytes: Towards Protective Therapy for the Heart by Schwach, Verena, Slaats, Rolf H, Cofino Fabres, Carla, ten Den, Simone A, Rivera-Arbelaez, Jose, van der Zanden, Sabina, Neefjes, Jacques, Ribeiro, Marcelo C, Cao, Lu, Passier, Robert

“…IntroductionCardiotoxicity is one of the main adverse effects of cancer therapy and has been extensively assessed in animal models which are not predictive for…”
Get full text