Search Results - "Fabienne, Rajas"

Gut-Brain Glucose Signaling in Energy Homeostasis by Soty, Maud, Gautier-Stein, Amandine, Rajas, Fabienne, Mithieux, Gilles

“…Intestinal gluconeogenesis is a recently identified function influencing energy homeostasis. Intestinal gluconeogenesis induced by specific nutrients releases…”
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Glucose-6 Phosphate, A Central Hub for Liver Carbohydrate Metabolism by Rajas, Fabienne, Gautier-Stein, Amandine, Mithieux, Gilles

“…Cells efficiently adjust their metabolism according to the abundance of nutrients and energy. The ability to switch cellular metabolism between anabolic and…”
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Metabolic Adaptation Establishes Disease Tolerance to Sepsis by Weis, Sebastian, Carlos, Ana Rita, Moita, Maria Raquel, Singh, Sumnima, Blankenhaus, Birte, Cardoso, Silvia, Larsen, Rasmus, Rebelo, Sofia, Schäuble, Sascha, Del Barrio, Laura, Mithieux, Gilles, Rajas, Fabienne, Lindig, Sandro, Bauer, Michael, Soares, Miguel P.

“…Sepsis is an often lethal syndrome resulting from maladaptive immune and metabolic responses to infection, compromising host homeostasis. Disease tolerance is…”
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Intestinal gluconeogenesis prevents obesity-linked liver steatosis and non-alcoholic fatty liver disease by Vily-Petit, Justine, Soty-Roca, Maud, Silva, Marine, Raffin, Margaux, Gautier-Stein, Amandine, Rajas, Fabienne, Mithieux, Gilles

“…Hepatic steatosis accompanying obesity is a major health concern, since it may initiate non-alcoholic fatty liver disease (NAFLD) and associated complications…”
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Hepatic stress associated with pathologies characterized by disturbed glucose production by Gjorgjieva, Monika, Mithieux, Gilles, Rajas, Fabienne

“…The liver is an organ with many facets, including a role in energy production and metabolic balance, detoxification and extraordinary capacity of regeneration…”
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G6PC mRNA Therapy Positively Regulates Fasting Blood Glucose and Decreases Liver Abnormalities in a Mouse Model of Glycogen Storage Disease 1a by Roseman, Daniel S., Khan, Tayeba, Rajas, Fabienne, Jun, Lucy S., Asrani, Kirtika H., Isaacs, Cleo, Farelli, Jeremiah D., Subramanian, Romesh R.

“…Glycogen storage disease type Ia (GSD1a) is an inherited metabolic disorder caused by the deficiency of glucose-6-phosphatase (G6Pase). GSD1a is associated…”
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Intestinal gluconeogenesis is crucial to maintain a physiological fasting glycemia in the absence of hepatic glucose production in mice by Penhoat, Armelle, Fayard, Laetitia, Stefanutti, Anne, Mithieux, Gilles, Rajas, Fabienne

“…Abstract Objective Similar to the liver and kidneys, the intestine has been strongly suggested to be a gluconeogenic organ. However, the precise contribution…”
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Intracellular lipids are an independent cause of liver injury and chronic kidney disease in non alcoholic fatty liver disease-like context by Monteillet, Laure, Gjorgjieva, Monika, Silva, Marine, Verzieux, Vincent, Imikirene, Linda, Duchampt, Adeline, Guillou, Hervé, Mithieux, Gilles, Rajas, Fabienne

“…Ectopic lipid accumulation in the liver and kidneys is a hallmark of metabolic diseases leading to non-alcoholic fatty liver disease (NAFLD) and chronic kidney…”
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Hepatic Carbohydrate Response Element Binding Protein Activation Limits Nonalcoholic Fatty Liver Disease Development in a Mouse Model for Glycogen Storage Disease Type 1a by Lei, Yu, Hoogerland, Joanne A., Bloks, Vincent W., Bos, Trijnie, Bleeker, Aycha, Wolters, Henk, Wolters, Justina C., Hijmans, Brenda S., Dijk, Theo H., Thomas, Rachel, Weeghel, Michel, Mithieux, Gilles, Houtkooper, Riekelt H., Bruin, Alain, Rajas, Fabienne, Kuipers, Folkert, Oosterveer, Maaike H.

“…Background and Aims Glycogen storage disease (GSD) type 1a is an inborn error of metabolism caused by defective glucose‐6‐phosphatase catalytic subunit (G6PC)…”
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Intestinal gluconeogenesis controls the neonatal development of hypothalamic feeding circuits by Estrada-Meza, Judith, Videlo, Jasmine, Bron, Clara, Duchampt, Adeline, Saint-Béat, Cécile, Zergane, Mickael, Silva, Marine, Rajas, Fabienne, Bouret, Sebastien G., Mithieux, Gilles, Gautier-Stein, Amandine

“…Intestinal gluconeogenesis (IGN) regulates adult energy homeostasis in part by controlling the same hypothalamic targets as leptin. In neonates, leptin…”
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A caveolin-1 dependent glucose-6-phosphatase trafficking contributes to hepatic glucose production by Gautier-Stein, Amandine, Chilloux, Julien, Soty, Maud, Thorens, Bernard, Place, Christophe, Zitoun, Carine, Duchampt, Adeline, Da Costa, Lorine, Rajas, Fabienne, Lamaze, Christophe, Mithieux, Gilles

“…Deregulation of hepatic glucose production is a key driver in the pathogenesis of diabetes, but its short-term regulation is incompletely deciphered. According…”
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Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein by Mithieux, Gilles, Misery, Pierre, Magnan, Christophe, Pillot, Bruno, Gautier-Stein, Amandine, Bernard, Christine, Rajas, Fabienne, Zitoun, Carine

“…Protein feeding is known to decrease hunger and subsequent food intake in animals and humans. It has also been suggested that glucose appearance into portal…”
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A novel role for glucose 6-phosphatase in the small intestine in the control of glucose homeostasis by Mithieux, Gilles, Rajas, Fabienne, Gautier-Stein, Amandine

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The role of kidney in the inter-organ coordination of endogenous glucose production during fasting by Kaneko, Keizo, Soty, Maud, Zitoun, Carine, Duchampt, Adeline, Silva, Marine, Philippe, Erwann, Gautier-Stein, Amandine, Rajas, Fabienne, Mithieux, Gilles

“…The respective contributions to endogenous glucose production (EGP) of the liver, kidney and intestine vary during fasting. We previously reported that the…”
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A link between hepatic glucose production and peripheral energy metabolism via hepatokines by Abdul-Wahed, Aya, Gautier-Stein, Amandine, Casteras, Sylvie, Soty, Maud, Roussel, Damien, Romestaing, Caroline, Guillou, Hervé, Tourette, Jean-André, Pleche, Nicolas, Zitoun, Carine, Gri, Blandine, Sardella, Anne, Rajas, Fabienne, Mithieux, Gilles

“…Abstract Type 2 diabetes is characterized by a deterioration of glucose tolerance, which associates insulin resistance of glucose uptake by peripheral tissues…”
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Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia by La Rose, Anouk M., Bazioti, Venetia, Hoogerland, Joanne A., Svendsen, Arthur F., Groenen, Anouk G., van Faassen, Martijn, Rutten, Martijn G.S., Kloosterhuis, Niels J., Dethmers-Ausema, Bertien, Nijland, J. Hendrik, Mithieux, Gilles, Rajas, Fabienne, Kuipers, Folkert, Lukens, Michaël V., Soehnlein, Oliver, Oosterveer, Maaike H., Westerterp, Marit

“…Glycogen storage disease type 1a (GSD Ia) is a rare inherited metabolic disorder caused by mutations in the glucose-6-phosphatase (G6PC1) gene. When untreated,…”
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Pathogenesis of Hepatic Tumors following Gene Therapy in Murine and Canine Models of Glycogen Storage Disease by Kang, Hye-Ri, Gjorgjieva, Monika, Smith, Stephanie N., Brooks, Elizabeth D., Chen, Zelin, Burgess, Shawn M., Chandler, Randy J., Waskowicz, Lauren R., Grady, Kylie M., Li, Songtao, Mithieux, Gilles, Venditti, Charles P., Rajas, Fabienne, Koeberl, Dwight D.

“…Glycogen storage disease type Ia (GSD Ia) is caused by mutations in the glucose-6-phosphatase (G6Pase) catalytic subunit gene (G6PC). GSD Ia complications…”
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Increased atherosclerosis in a mouse model of glycogen storage disease type 1a by La Rose, Anouk M., Groenen, Anouk G., Halmos, Benedek, Bazioti, Venetia, Rutten, Martijn G.S., Krishnamurthy, Kishore A., Koster, Mirjam H., Kloosterhuis, Niels J., Smit, Marieke, Havinga, Rick, Mithieux, Gilles, Rajas, Fabienne, Kuipers, Folkert, Oosterveer, Maaike H., Westerterp, Marit

“…Glycogen storage disease type 1a (GSD Ia) is an inborn error of carbohydrate metabolism. Despite severe hyperlipidemia, GSD Ia patients show limited…”
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In vivo hepatic lipid quantification using MRS at 7 Tesla in a mouse model of glycogen storage disease type 1a by Ramamonjisoa, Nirilanto, Ratiney, Helene, Mutel, Elodie, Guillou, Herve, Mithieux, Gilles, Pilleul, Frank, Rajas, Fabienne, Beuf, Olivier, Cavassila, Sophie

“…The assessment of liver lipid content and composition is needed in preclinical research to investigate steatosis and steatosis-related disorders. The purpose…”
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Mechanisms by Which Metabolic Reprogramming in GSD1 Liver Generates a Favorable Tumorigenic Environment by Gjorgjieva, Monika, Oosterveer, Maaike H., Mithieux, Gilles, Rajas, Fabienne

“…Glycogen storage disease type 1 (GSD1) is an inherited disorder caused by impaired glucose 6-phosphatase activity. This impairment translates into the…”
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