Search Results - "Fabianowska‐Majewska, Krystyna"
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The role of lipid droplets and adipocytes in cancer. Raman imaging of cell cultures: MCF10A, MCF7, and MDA-MB-231 compared to adipocytes in cancerous human breast tissue
Published in Analyst (London) (07-04-2015)“…We have studied live non-malignant (MCF10A), mildly malignant (MCF7) and malignant (MDA-MB-231) breast cancer cells and human breast cancer tissue. We…”
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The Role of Sulforaphane in Epigenetic Mechanisms, Including Interdependence between Histone Modification and DNA Methylation
Published in International journal of molecular sciences (12-12-2015)“…Carcinogenesis as well as cancer progression result from genetic and epigenetic changes of the genome that leads to dysregulation of transcriptional activity…”
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The chronic wound milieu changes essential oils' antibiofilm activity—an in vitro and larval model study
Published in Scientific reports (26-01-2024)“…Essential Oils (EOs) are currently being researched as potential antibiofilm agents to combat infections related to chronic wound biofilms. As documented in…”
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Curcumin from Turmeric Rhizome: A Potential Modulator of DNA Methylation Machinery in Breast Cancer Inhibition
Published in Nutrients (23-01-2021)“…One of the most systematically studied bioactive nutraceuticals for its benefits in the management of various diseases is the turmeric-derived compounds:…”
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Lunasin and Its Epigenetic Impact in Cancer Chemoprevention
Published in International journal of molecular sciences (24-05-2023)“…Cancer diseases are a leading cause of death worldwide. Therefore, it is pivotal to search for bioactive dietary compounds that can avert tumor development. A…”
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Hypomethylation and induction of retinoic acid receptor beta 2 by concurrent action of adenosine analogues and natural compounds in breast cancer cells
Published in European journal of pharmacology (25-07-2010)“…DNA methylation is considered as a potential cause of aberrations in regulation of gene expression during carcinogenesis. Therefore, changes in DNA methylation…”
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Novel Clofarabine-Based Combinations with Polyphenols Epigenetically Reactivate Retinoic Acid Receptor Beta, Inhibit Cell Growth, and Induce Apoptosis of Breast Cancer Cells
Published in International journal of molecular sciences (10-12-2018)“…An epigenetic component, especially aberrant DNA methylation pattern, has been shown to be frequently involved in sporadic breast cancer development. A growing…”
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Relationship of muscle function to circulating myostatin, follistatin and GDF11 in older women and men
Published in BMC geriatrics (30-08-2018)“…Myostatin, its inhibitor follistatin, and growth/differentiation factor 11 (GDF11) have been proposed as factors that could potentially modify biological…”
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Clofarabine‑phytochemical combination exposures in CML cells inhibit DNA methylation machinery, upregulate tumor suppressor genes and promote caspase‑dependent apoptosis
Published in Molecular medicine reports (01-10-2019)“…Clofarabine (2‑chloro‑2'‑fluoro‑2'‑deoxyarabinosyladenine, CIF), a second‑generation 2'‑deoxyadenosine analog, possesses a variety of anti‑cancer activities,…”
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Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562
Published in British journal of haematology (01-07-1999)“…Resistant variants of the human leukaemic line K562 were developed using selection with the deoxynucleoside analogues cytosine arabinoside,…”
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Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells
Published in British journal of nutrition (28-03-2012)“…Aberrations in DNA methylation patterns have been reported to be involved in driving changes in the expression of numerous genes during carcinogenesis and have…”
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The levels of 7,8-dihydrodeoxyguanosine (8-oxoG) and 8-oxoguanine DNA glycosylase 1 (OGG1) – A potential diagnostic biomarkers of Alzheimer's disease
Published in Journal of the neurological sciences (15-09-2016)“…Abstract Evidence indicates that oxidative stress contributes to neuronal cell death in Alzheimer's disease (AD). Increased oxidative DNA damage l , as…”
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Epigenetic changes in cancer by Raman imaging, fluorescence imaging, AFM and scanning near-field optical microscopy (SNOM). Acetylation in normal and human cancer breast cells MCF10A, MCF7 and MDA-MB-231
Published in Analyst (London) (07-10-2016)“…This paper examines epigenetic changes in breast cancer by Raman imaging, fluorescence imaging, AFM and SNOM and discusses how they contribute to different…”
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Inhibition of breast cancer cell growth by the combination of clofarabine and sulforaphane involves epigenetically mediated CDKN2A upregulation
Published in Nucleosides, nucleotides & nucleic acids (01-01-2018)“…Many antineoplastic nucleoside analogue-based combinatorial strategies focused on remodelling aberrant DNA methylation patterns have been developed. The number…”
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Folic acid enforces DNA methylation-mediated transcriptional silencing of PTEN, APC and RARbeta2 tumour suppressor genes in breast cancer
Published in Biochemical and biophysical research communications (11-01-2013)“…► High level of folic acid led to PTEN, RARbeta2 and APC promoters hypermethylation. ► Folic acid caused DNA-mediated transcriptional silencing of PTEN,…”
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Clofarabine, a novel adenosine analogue, reactivates DNA methylation-silenced tumour suppressor genes and inhibits cell growth in breast cancer cells
Published in European journal of pharmacology (15-01-2014)“…Clofarabine (2-chloro-2′-fluoro-2′-deoxyarabinosyladenine, ClF) is a second-generation 2′-deoxyadenosine analogue that is structurally related to cladribine…”
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Sulforaphane Alone and in Combination with Clofarabine Epigenetically Regulates the Expression of DNA Methylation-Silenced Tumour Suppressor Genes in Human Breast Cancer Cells
Published in Journal of nutrigenetics and nutrigenomics (01-01-2015)“…Background/Aim: Sporadic breast cancer is frequently associated with aberrant DNA methylation patterns that are reversible and responsive to environmental…”
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Influence of bioactive metal fillers on antimicrobial properties of PA12 composites produced by laser-based Powder Bed Fusion of Polymers
Published in Acta of bioengineering and biomechanics (01-12-2023)“…Purpose This study investigated the influence of three types of metallic microfillers, spherical silver and spherical, and dendritic copper, on the ability of…”
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Clofarabine (2-chloro-2'-fluoro-2'-deoxyarabinosyladenine)--biochemical aspects of anticancer activity
Published in Acta Poloniae pharmaceutica (01-07-2011)“…Clofarabine (2-chloro-2'-fluoro-2'-deoxyarabinosyladenine) is a second generation analogue of 2'-deoxyadenosine connecting biochemical activities of its…”
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The effects of cladribine and fludarabine on DNA methylation in K562 cells
Published in Biochemical pharmacology (15-01-2003)“…The effects of the antileukemic adenosine analogues, 2-chloro-2′-deoxyadenosine (cladribine) and 9-β- d-arabinosyl-2-fluoroadenine (fludarabine), on DNA…”
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