Search Results - "Fabian Chen"

Initiating sacubitril/valsartan (LCZ696) in heart failure: results of TITRATION, a double-blind, randomized comparison of two uptitration regimens by Senni, Michele, McMurray, John J.V., Wachter, Rolf, McIntyre, Hugh F., Reyes, Antonio, Majercak, Ivan, Andreka, Peter, Shehova-Yankova, Nina, Anand, Inder, Yilmaz, Mehmet B., Gogia, Harinder, Martinez-Selles, Manuel, Fischer, Steffen, Zilahi, Zsolt, Cosmi, Franco, Gelev, Valeri, Galve, Enrique, Gómez-Doblas, Juanjo J., Nociar, Jan, Radomska, Maria, Sokolova, Beata, Volterrani, Maurizio, Sarkar, Arnab, Reimund, Bernard, Chen, Fabian, Charney, Alan

“…Aims To assess the tolerability of initiating/uptitrating sacubitril/valsartan (LCZ696) from 50 to 200 mg twice daily (target dose) over 3 and 6 weeks in heart…”
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Prevalence and Characteristics of Hepatitis B Virus (HBV) Coinfection among HIV-Positive Women in South Africa and Botswana by Matthews, Philippa C, Beloukas, Apostolos, Malik, Amna, Carlson, Jonathan M, Jooste, Pieter, Ogwu, Anthony, Shapiro, Roger, Riddell, Lynn, Chen, Fabian, Luzzi, Graz, Jaggernath, Manjeetha, Jesuthasan, Gerald, Jeffery, Katie, Ndung'u, Thumbi, Goulder, Philip J R, Geretti, Anna Maria, Klenerman, Paul

“…There is progressive concern about the evolving burden of morbidity and mortality caused by coinfection with HIV-1 and hepatitis B virus (HBV) in sub-Saharan…”
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Peripheral Neuropathy in Virologically Suppressed People Living with HIV: Evidence from the PIVOT Trial by Schuldt, Anna L, Bern, Henry, Hart, Melanie, Gompels, Mark, Winston, Alan, Clarke, Amanda, Chen, Fabian, Stöhr, Wolfgang, Heslegrave, Amanda, Paton, Nicholas I, Petzold, Axel, Arenas-Pinto, Alejandro

“…The aim of this study is to identify the factors associated with peripheral neuropathy and to explore neurofilament light chain (NfL) as a biomarker for…”
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HLA-B57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control by KLOVERPRIS, Henrik N, STRYHN, Anette, BUUS, Soren, GOULDER, Philip, HARNDAHL, Mikkel, VAN DER STOK, Mary, PAYNE, Rebecca P, MATTHEW, Phiiippa C, FABIAN CHEN, RIDDELL, Lynn, WALKER, Bruce D, NDUNG'U, Thumbi

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Immunodominant cytomegalovirus-specific CD8+ T-cell responses in sub-Saharan African populations by Malik, Amna, Adland, Emily, Laker, Leana, Kløverpris, Henrik, Fardoos, Rabiah, Roider, Julia, Severinsen, Mai C, Chen, Fabian, Riddell, Lynn, Edwards, Anne, Buus, Søren, Jooste, Pieter, Matthews, Philippa C, Goulder, Philip J R

“…More than 90% of children in Africa are infected with cytomegalovirus (CMV) by the age of 12 months. However, the high-frequency, immunodominant CD8+ T-cell…”
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Efficacious Early Antiviral Activity of HIV Gag- and Pol-Specific HLA-B2705-Restricted CD8+ T Cells by PAYNE, Rebecca P, KLØVERPRIS, Henrik, LUZZI, Graz, EDWARDS, Anne, PHILLIPS, Rodney, PRADO, Julia G, GOULDER, Philip J. R, SACHA, Jonah B, BRUMME, Zabrina, BRUMME, Chanson, BUUS, Søren, SIMS, Stuart, HICKLING, Stephen, RIDDELL, Lynn, FABIAN CHEN

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Early Antigen Presentation of Protective HIV-1 KF11Gag and KK10Gag Epitopes from Incoming Viral Particles Facilitates Rapid Recognition of Infected Cells by Specific CD8+ T Cells by Kløverpris, Henrik N., Payne, Rebecca P., Sacha, Jonah B., Rasaiyaah, Jane T., Chen, Fabian, Takiguchi, Masafumi, Yang, Otto O., Towers, Greg J., Goulder, Philip, Prado, Julia G.

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Differential Clade-Specific HLA-B3501 Association with HIV-1 Disease Outcome Is Linked to Immunogenicity of a Single Gag Epitope by MATTHEWS, Philippa C, KOYANAGI, Madoka, AVILA RIOS, Santiago, COLE, David, CARLSON, Jonathan, PAYNE, Rebecca P, OGWU, Anthony, BERE, Alfred, NDUNG'U, Thumbi, GOUNDER, Kamini, FABIAN CHEN, RIDDELL, Lynn, KLØVERPRIS, Henrik N, LUZZI, Graz, SHAPIRO, Roger, BRANDER, Christian, WALKER, Bruce, SEWELL, Andrew K, REYES TERAN, Gustavo, HECKERMAN, David, HUNTER, Eric, BUUS, Soren, TAKIGUCHI, Masafumi, HARNDAHL, Mikkel, GOULDER, Philip J. R, STRYHN, Anette, AKAHOSHI, Tomohiro, GATANAGA, Hiroyuki, OKA, Shinichi, JUAREZ MOLINA, Claudia, VALENZUELA PONCE, Humberto

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Rapid HIV disease progression following superinfection in an HLA-B27:05/B57:01-positive transmission recipient by Brener, Jacqui, Gall, Astrid, Hurst, Jacob, Batorsky, Rebecca, Lavandier, Nora, Chen, Fabian, Edwards, Anne, Bolton, Chrissy, Dsouza, Reena, Allen, Todd, Pybus, Oliver G, Kellam, Paul, Matthews, Philippa C, Goulder, Philip J R

“…The factors determining differential HIV disease outcome among individuals expressing protective HLA alleles such as HLA-B*27:05 and HLA-B*57:01 remain…”
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CD8+ TCR Bias and Immunodominance in HIV-1 Infection by Kløverpris, Henrik N, McGregor, Reuben, McLaren, James E, Ladell, Kristin, Harndahl, Mikkel, Stryhn, Anette, Carlson, Jonathan M, Koofhethile, Catherine, Gerritsen, Bram, Keşmir, Can, Chen, Fabian, Riddell, Lynn, Luzzi, Graz, Leslie, Alasdair, Walker, Bruce D, Ndung'u, Thumbi, Buus, Søren, Price, David A, Goulder, Philip J

“…Immunodominance describes a phenomenon whereby the immune system consistently targets only a fraction of the available Ag pool derived from a given pathogen…”
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Nef-specific CD8+ T cell responses contribute to HIV-1 immune control by Adland, Emily, Carlson, Jonathan M, Paioni, Paolo, Kløverpris, Henrik, Shapiro, Roger, Ogwu, Anthony, Riddell, Lynn, Luzzi, Graz, Chen, Fabian, Balachandran, Thambiah, Heckerman, David, Stryhn, Anette, Edwards, Anne, Ndung'u, Thumbi, Walker, Bruce D, Buus, Søren, Goulder, Philip, Matthews, Philippa C

“…Recent studies in the SIV-macaque model of HIV infection suggest that Nef-specific CD8+ T-cell responses may mediate highly effective immune control of…”
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Protease inhibitor monotherapy for long-term management of HIV infection: a randomised, controlled, open-label, non-inferiority trial by Paton, Nicholas I, Prof, Stöhr, Wolfgang, PhD, Arenas-Pinto, Alejandro, PhD, Fisher, Martin, Prof, Williams, Ian, FRCP, Johnson, Margaret, Prof, Orkin, Chloe, MBBCh, Chen, Fabian, FRCP, Lee, Vincent, MBChB, Winston, Alan, MD, Gompels, Mark, MBBS, Fox, Julie, MD, Scott, Karen, BA, Dunn, David T, Prof

“…Summary Background Standard-of-care antiretroviral therapy (ART) uses a combination of drugs deemed essential to minimise treatment failure and drug…”
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Saporin-conjugated tetramers identify efficacious anti-HIV CD8+ T-cell specificities by Leitman, Ellen M, Palmer, Christine D, Buus, Søren, Chen, Fabian, Riddell, Lynn, Sims, Stuart, Klenerman, Paul, Sáez-Cirión, Asier, Walker, Bruce D, Hess, Paul R, Altfeld, Marcus, Matthews, Philippa C, Goulder, Philip J R

“…Antigen-specific T-cells are highly variable, spanning potent antiviral efficacy and damaging auto-reactivity. In virus infections, identifying the most…”
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Effectiveness and Safety of Laropiprant on Niacin-Induced Flushing by Maccubbin, Darbie L., PhD, Chen, Fabian, MD, PhD, Anderson, Jennifer Weimer, BS, Sirah, Waheeda, BS, McCrary Sisk, Christine, BS, Kher, Uma, PhD, Olsson, Anders G., MD, PhD, Bays, Harold E., MD, Mitchel, Yale B., MD

“…Extended-release niacin (ERN) improves multiple lipid parameters but is underused owing to niacin-induced flushing (NIF). Laropiprant (LRPT) reduces NIF;…”
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HIV Control through a Single Nucleotide on the HLA-B Locus by Kløverpris, Henrik N, Harndahl, Mikkel, Leslie, Alasdair J, Carlson, Jonathan M, Ismail, Nasreen, van der Stok, Mary, Huang, Kuan-Hsiang Gary, Chen, Fabian, Riddell, Lynn, Steyn, Dewald, Goedhals, Dominique, van Vuuren, Cloete, Frater, John, Walker, Bruce D, Carrington, Mary, Ndung'u, Thumbi, Buus, Søren, Goulder, Philip

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N-Terminal Propeptide of Type III Procollagen as a Biomarker of Anabolic Response to Recombinant Human GH and Testosterone by Bhasin, Shalender, He, E. Jiaxiu, Kawakubo, Miwa, Schroeder, E. Todd, Yarasheski, Kevin, Opiteck, Gregory J., Reicin, Alise, Chen, Fabian, Lam, Raymond, Tsou, Jeffrey A., Castaneda-Sceppa, Carmen, Binder, Ellen F., Azen, Stanley P., Sattler, Fred R.

“…Context: Biomarkers that predict musculoskeletal response to anabolic therapies should expedite drug development. During collagen synthesis in soft lean…”
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HLA-Specific Intracellular Epitope Processing Shapes an Immunodominance Pattern for HLA-B57 That Is Distinct from HLA-B58:01 by Kløverpris, Henrik N, Stryhn, Anette, Harndahl, Mikkel, Payne, Rebecca, Towers, Greg J, Chen, Fabian, Riddell, Lynn, Walker, Bruce D, Ndung'u, Thumbi, Leslie, Alasdair, Buus, Søren, Goulder, Philip

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Muscleblind‐like 2 (Mbnl2) ‐deficient mice as a model for myotonic dystrophy by Hao, Minqi, Akrami, Kevan, Wei, Ke, De Diego, Carlos, Che, Nam, Ku, Jeong‐Hee, Tidball, James, Graves, Michael C., Shieh, Perry B., Chen, Fabian

“…Myotonic dystrophy (DM), the most common adult‐onset muscular dystrophy, is caused by CTG or CCTG microsatellite repeat expansions. Expanded DM mRNA…”
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Non-immunogenicity of overlapping gag peptides pulsed on autologous cells after vaccination of HIV infected individuals by Kløverpris, Henrik N, Jackson, Akil, Handley, Amanda, Hayes, Peter, Gilmour, Jill, Riddell, Lynn, Chen, Fabian, Atkins, Mark, Boffito, Marta, Walker, Bruce D, Ackland, Jim, Sullivan, Mark, Goulder, Philip

“…HIV Gag-specific CD4+ and CD8+ T-cell responses are important for HIV immune control. Pulsing overlapping Gag peptides on autologous lymphocytes (OPAL) has…”
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A randomised, placebo-controlled, first-in-human study of a novel clade C therapeutic peptide vaccine administered ex vivo to autologous white blood cells in HIV infected individuals by Jackson, Akil, Kløverpris, Henrik N, Boffito, Marta, Handley, Amanda, Atkins, Mark, Hayes, Peter, Gilmour, Jill, Riddel, Lynn, Chen, Fabian, Bailey-Tippets, Melanie, Walker, Bruce, Ackland, Jim, Sullivan, Mark, Goulder, Philip

“…Preclinical studies of overlapping 15mer peptides, spanning SIV, SHIV or HIV, pulsed on autologous PBMC ex vivo have demonstrated high level, virus-specific T…”
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