Search Results - "Fabian, June"
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The Use of 'Omics for Diagnosing and Predicting Progression of Chronic Kidney Disease: A Scoping Review
Published in Frontiers in genetics (08-11-2021)“…Globally, chronic kidney disease (CKD) contributes substantial morbidity and mortality. Recently, various 'omics platforms have provided insight into the…”
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The impact of diabetes and hypertension on renal allograft survival— A single center study
Published in Current urology (01-12-2023)“…Abstract Background To determine the impact of pre-transplant diabetes mellitus (DM) and post-transplant hypertension (HT) at 1 year on renal allograft…”
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End-of-life care and organ donation in South Africa – it’s time for national policy to lead the way
Published in South African medical journal (01-07-2017)“…South Africa (SA)’s healthcare system has the expertise and facilities to provide solid-organ transplantation for those with end-stage disease. In spite of…”
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Challenges in Expanding Access to Dialysis in South Africa-Expensive Modalities, Cost Constraints and Human Rights
Published in Healthcare (Basel) (31-07-2017)“…South Africa is a country with two distinct health sectors, which are both characterised by inequalities. Within this context, patients with end stage renal…”
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Kidney dysfunction: prevalence and associated risk factors in a community-based study from the North West Province of South Africa
Published in BMC nephrology (30-01-2023)“…Globally, the World Health Organization ranks chronic kidney disease (CKD) as one of the top 10 causes of mortality. In South Africa, where noncommunicable…”
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Liver Transplant for Nonresectable Colorectal Cancer Liver Metastases in South Africa: A Single-Center Case Series
Published in Experimental and clinical transplantation (01-12-2020)“…Objectives: Publication in 2013 of the first Secondary Cancer cohort study returned attention to liver transplant for nonresectable colorectal cancer,…”
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Emphasising Organisational Routine: A Qualitative Study of Patient and Health Professional Experiences of Inpatient Oncology Care
Published in Healthcare (Basel) (28-10-2022)“…Background: Although the experience of hospitalisation for cancer management has been widely researched, such research from the African sub-continent is…”
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A machine learning approach towards assessing consistency and reproducibility: an application to graft survival across three kidney transplantation eras
Published in Frontiers in digital health (03-09-2024)“…In South Africa, between 1966 and 2014, there were three kidney transplant eras defined by evolving access to certain immunosuppressive therapies defined as…”
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Proteomic Analysis Identifies Dysregulated Proteins in Albuminuria: A South African Pilot Study
Published in Biology (Basel, Switzerland) (01-09-2024)“…Albuminuria may precede decreases in the glomerular filtration rate (GFR) and both tests are insensitive predictors of early stages of kidney disease. Our aim…”
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Kidney damage and associated risk factors in rural and urban sub-Saharan Africa (AWI-Gen): a cross-sectional population study
Published in The Lancet global health (01-12-2019)“…Rapid epidemiological health transitions occurring in vulnerable populations in Africa that have an existing burden of infectious and non-communicable diseases…”
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The clinical and histological response of HIV-associated kidney disease to antiretroviral therapy in South Africans
Published in Nephrology, dialysis, transplantation (01-06-2013)“…Little is known about the progression of kidney disease in HIV-infected patients in developing countries in the era of antiretroviral therapy (ART)…”
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Blood pressure increases are associated with weight gain and not antiretroviral regimen or kidney function: a secondary analysis from the ADVANCE trial in South Africa
Published in Journal of the International AIDS Society (01-07-2024)“…Introduction Recent evidence has raised questions about whether newer HIV treatment regimens, including dolutegravir (DTG) and tenofovir alafenamide (TAF), are…”
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Genetic association and transferability for urinary albumin-creatinine ratio as a marker of kidney disease in four Sub-Saharan African populations and non-continental individuals of African ancestry
Published in Frontiers in genetics (15-05-2024)“…Genome-wide association studies (GWAS) have predominantly focused on populations of European and Asian ancestry, limiting our understanding of genetic factors…”
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Obesity is South Africa’s new HIV epidemic
Published in South African medical journal (01-03-2024)“…World Obesity Day is on 4 March 2024, and our nation needs to pay attention. As with the HIV epidemic in the 1990s, we are facing a calamitous threat to the…”
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An overview of tenofovir and renal disease for the HIV-treating clinician
Published in Southern African journal of HIV medicine (2018)“…Tenofovir disoproxil fumarate (TDF, commonly termed ‘tenofovir’) is the antiretroviral most commonly implicated in antiretroviral-induced nephrotoxicity. As…”
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Diagnostic accuracy of semiquantitative point of care urine albumin to creatinine ratio and urine dipstick analysis in a primary care resource limited setting in South Africa
Published in BMC nephrology (20-03-2021)“…The prevalence of chronic kidney disease (CKD) is predicted to rise over the next few decades. In resource-limited settings access to central laboratory…”
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Use of Machine Learning and Statistical Algorithms to Predict Hospital Length of Stay Following Colorectal Cancer Resection: A South African Pilot Study
Published in Frontiers in oncology (01-10-2021)“…The aim of this pilot study was to develop logistic regression (LR) and support vector machine (SVM) models that differentiate low from high risk for prolonged…”
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How to estimate glomerular filtration rate in sub-Saharan Africa: design and methods of the African Research into Kidney Diseases (ARK) study
Published in BMC nephrology (15-01-2020)“…Chronic kidney disease (CKD) is a substantial cause of morbidity and mortality worldwide with disproportionate effects in sub-Saharan Africa (SSA). The optimal…”
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Identifying the prevalence and correlates of multimorbidity in middle-aged men and women: a cross-sectional population-based study in four African countries
Published in BMJ open (14-03-2023)“…ObjectivesTo determine the prevalence of multimorbidity, to identify which chronic conditions cluster together and to identify factors associated with a…”
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Modeling Long-Term Graft Survival With Time-Varying Covariate Effects: An Application to a Single Kidney Transplant Centre in Johannesburg, South Africa
Published in Frontiers in public health (25-07-2019)“…Patients' characteristics that could influence graft survival may also exhibit non-constant effects over time; therefore, violating the important assumption of…”
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