Search Results - "Fabian, Daniel K."

Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America by Fabian, Daniel K., Kapun, Martin, Nolte, Viola, Kofler, Robert, Schmidt, Paul S., Schlötterer, Christian, Flatt, Thomas

“…Understanding the genetic underpinnings of adaptive change is a fundamental but largely unresolved problem in evolutionary biology. Drosophila melanogaster, an…”
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Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving viruses in Drosophila melanogaster by Magwire, Michael M, Fabian, Daniel K, Schweyen, Hannah, Cao, Chuan, Longdon, Ben, Bayer, Florian, Jiggins, Francis M

“…Variation in susceptibility to infectious disease often has a substantial genetic component in animal and plant populations. We have used genome-wide…”
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Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in Drosophila by Machado, Heather E, Bergland, Alan O, Taylor, Ryan, Tilk, Susanne, Behrman, Emily, Dyer, Kelly, Fabian, Daniel K, Flatt, Thomas, González, Josefa, Karasov, Talia L, Kim, Bernard, Kozeretska, Iryna, Lazzaro, Brian P, Merritt, Thomas Js, Pool, John E, O'Brien, Katherine, Rajpurohit, Subhash, Roy, Paula R, Schaeffer, Stephen W, Serga, Svitlana, Schmidt, Paul, Petrov, Dmitri A

“…To advance our understanding of adaptation to temporally varying selection pressures, we identified signatures of seasonal adaptation occurring in parallel…”
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Functional conservation in genes and pathways linking ageing and immunity by Fabian, Daniel K, Fuentealba, Matías, Dönertaş, Handan Melike, Partridge, Linda, Thornton, Janet M

“…At first glance, longevity and immunity appear to be different traits that have not much in common except the fact that the immune system promotes survival…”
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Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster by Betancourt, Nicolas J., Rajpurohit, Subhash, Durmaz, Esra, Fabian, Daniel K., Kapun, Martin, Flatt, Thomas, Schmidt, Paul

“…The insulin/insulin‐like growth factor signalling pathway has been hypothesized as a major determinant of life‐history profiles that vary adaptively in natural…”
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Protocol for preparing Drosophila genomic DNA to create chromosome-level de novo genome assemblies by Sperling, Alexis L., Fabian, Daniel K., Garrison, Erik, Glover, David M.

“…De novo genome assemblies are common tools for examining novel biological phenomena in non-model organisms. Here, we present a protocol for preparing…”
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Genomic Evidence for Adaptive Inversion Clines in Drosophila melanogaster by Kapun, Martin, Fabian, Daniel K, Goudet, Jérôme, Flatt, Thomas

“…Clines in chromosomal inversion polymorphisms-presumably driven by climatic gradients-are common but there is surprisingly little evidence for selection acting…”
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A genetic basis for facultative parthenogenesis in Drosophila by Sperling, Alexis L., Fabian, Daniel K., Garrison, Erik, Glover, David M.

“…Facultative parthenogenesis enables sexually reproducing organisms to switch between sexual and asexual parthenogenetic reproduction. To gain insights into…”
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Male-killing Wolbachia do not protect Drosophila bifasciata against viral infection by Longdon, Ben, Fabian, Daniel K, Hurst, Gregory D D, Jiggins, Francis M

“…Insect symbionts employ multiple strategies to enhance their spread through populations, and some play a dual role as both a mutualist and a reproductive…”
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Common genetic associations between age-related diseases by Dönertaş, Handan Melike, Fabian, Daniel K, Valenzuela, Matías Fuentealba, Partridge, Linda, Thornton, Janet M

“…Age is a common risk factor in many diseases, but the molecular basis for this relationship is elusive. In this study we identified 4 disease clusters from 116…”
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Digest: Live fast or slow? Temperature does not impose selection on metabolic rate by Fabian, Daniel K.

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A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila by Durmaz, Esra, Rajpurohit, Subhash, Betancourt, Nicolas, Fabian, Daniel K., Kapun, Martin, Schmidt, Paul, Flatt, Thomas

“…A fundamental aim of adaptation genomics is to identify polymorphisms that underpin variation in fitness traits. In Drosophila melanogaster, latitudinal…”
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A novel transposable element-mediated mechanism causes antiviral resistance in Drosophila through truncating the Veneno protein by Brosh, Osama, Fabian, Daniel K, Cogni, Rodrigo, Tolosana, Ignacio, Day, Jonathan P, Olivieri, Francesca, Merckx, Manon, Akilli, Nazli, Szkuta, Piotr, Jiggins, Francis M

“…Hosts are continually selected to evolve new defenses against an ever-changing array of pathogens. To understand this process, we examined the genetic basis of…”
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Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice by Fuentealba, Matias, Fabian, Daniel K., Dönertaş, Handan Melike, Thornton, Janet M., Partridge, Linda

“…•Transcriptomic changes are more similar within mutant mice that show either lengthened or shortened lifespan.•The major transcriptomic differences between…”
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Transposable Element Landscape in Drosophila Populations Selected for Longevity by Fabian, Daniel K, Dönertaş, Handan Melike, Fuentealba, Matías, Partridge, Linda, Thornton, Janet M

“…Abstract Transposable elements (TEs) inflict numerous negative effects on health and fitness as they replicate by integrating into new regions of the host…”
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Evolution of longevity improves immunity in Drosophila by Fabian, Daniel K., Garschall, Kathrin, Klepsatel, Peter, Santos‐Matos, Gonçalo, Sucena, Élio, Kapun, Martin, Lemaitre, Bruno, Schlötterer, Christian, Arking, Robert, Flatt, Thomas

“…Much has been learned about the genetics of aging from studies in model organisms, but still little is known about naturally occurring alleles that contribute…”
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Digest: Live fast or slow? Temperature does not impose selection on metabolic rate: DIGESTS by Fabian, Daniel K.

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Drosophila Evolution over Space and Time (DEST): A New Population Genomics Resource by Kapun, Martin, Nunez, Joaquin C B, Bogaerts-Márquez, María, Murga-Moreno, Jesús, Paris, Margot, Outten, Joseph, Coronado-Zamora, Marta, Tern, Courtney, Rota-Stabelli, Omar, Guerreiro, Maria P García, Casillas, Sònia, Orengo, Dorcas J, Puerma, Eva, Kankare, Maaria, Ometto, Lino, Loeschcke, Volker, Onder, Banu S, Abbott, Jessica K, Schaeffer, Stephen W, Rajpurohit, Subhash, Behrman, Emily L, Schou, Mads F, Merritt, Thomas J S, Lazzaro, Brian P, Glaser-Schmitt, Amanda, Argyridou, Eliza, Staubach, Fabian, Wang, Yun, Tauber, Eran, Serga, Svitlana V, Fabian, Daniel K, Dyer, Kelly A, Wheat, Christopher W, Parsch, John, Grath, Sonja, Veselinovic, Marija Savic, Stamenkovic-Radak, Marina, Jelic, Mihailo, Buendía-Ruíz, Antonio J, Gómez-Julián, Maria Josefa, Espinosa-Jimenez, Maria Luisa, Gallardo-Jiménez, Francisco D, Patenkovic, Aleksandra, Eric, Katarina, Tanaskovic, Marija, Ullastres, Anna, Guio, Lain, Merenciano, Miriam, Guirao-Rico, Sara, Horváth, Vivien, Obbard, Darren J, Pasyukova, Elena, Alatortsev, Vladimir E, Vieira, Cristina P, Vieira, Jorge, Torres, Jorge Roberto, Kozeretska, Iryna, Maistrenko, Oleksandr M, Montchamp-Moreau, Catherine, Mukha, Dmitry V, Machado, Heather E, Lamb, Keric, Paulo, Tânia, Yusuf, Leeban, Barbadilla, Antonio, Petrov, Dmitri, Schmidt, Paul, Gonzalez, Josefa, Flatt, Thomas, Bergland, Alan O

“…Abstract Drosophila melanogaster is a leading model in population genetics and genomics, and a growing number of whole-genome data sets from natural…”
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Spatially varying selection shapes life history clines among populations of Drosophila melanogaster from sub‐Saharan Africa by Fabian, D. K, Lack, J. B, Mathur, V, Schlötterer, C, Schmidt, P. S, Pool, J. E, Flatt, T

“…Clines in life history traits, presumably driven by spatially varying selection, are widespread. Major latitudinal clines have been observed, for example, in…”
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Genome‐wide patterns of latitudinal differentiation among populations of D rosophila melanogaster from N orth A merica by Fabian, Daniel K., Kapun, Martin, Nolte, Viola, Kofler, Robert, Schmidt, Paul S., Schlötterer, Christian, Flatt, Thomas

“…Abstract Understanding the genetic underpinnings of adaptive change is a fundamental but largely unresolved problem in evolutionary biology. D rosophila…”
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