Search Results - "Faber, Zachary J"

Functional Enhancers Shape Extrachromosomal Oncogene Amplifications by Morton, Andrew R., Dogan-Artun, Nergiz, Faber, Zachary J., MacLeod, Graham, Bartels, Cynthia F., Piazza, Megan S., Allan, Kevin C., Mack, Stephen C., Wang, Xiuxing, Gimple, Ryan C., Wu, Qiulian, Rubin, Brian P., Shetty, Shashirekha, Angers, Stephane, Dirks, Peter B., Sallari, Richard C., Lupien, Mathieu, Rich, Jeremy N., Scacheri, Peter C.

“…Non-coding regions amplified beyond oncogene borders have largely been ignored. Using a computational approach, we find signatures of significant…”
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The genomic landscape of core-binding factor acute myeloid leukemias by Faber, Zachary J, Chen, Xiang, Gedman, Amanda Larson, Boggs, Kristy, Cheng, Jinjun, Ma, Jing, Radtke, Ina, Chao, Jyh-Rong, Walsh, Michael P, Song, Guangchun, Andersson, Anna K, Dang, Jinjun, Dong, Li, Liu, Yu, Huether, Robert, Cai, Zhongling, Mulder, Heather, Wu, Gang, Edmonson, Michael, Rusch, Michael, Qu, Chunxu, Li, Yongjin, Vadodaria, Bhavin, Wang, Jianmin, Hedlund, Erin, Cao, Xueyuan, Yergeau, Donald, Nakitandwe, Joy, Pounds, Stanley B, Shurtleff, Sheila, Fulton, Robert S, Fulton, Lucinda L, Easton, John, Parganas, Evan, Pui, Ching-Hon, Rubnitz, Jeffrey E, Ding, Li, Mardis, Elaine R, Wilson, Richard K, Gruber, Tanja A, Mullighan, Charles G, Schlenk, Richard F, Paschka, Peter, Döhner, Konstanze, Döhner, Hartmut, Bullinger, Lars, Zhang, Jinghui, Klco, Jeffery M, Downing, James R

“…Lars Bullinger, Jinghui Zhang, Jeffery Klco, James Downing and colleagues report a detailed genomic analysis of pediatric and adult core-binding factor acute…”
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Temporal chromatin accessibility changes define transcriptional states essential for osteosarcoma metastasis by Pontius, W. Dean, Hong, Ellen S., Faber, Zachary J., Gray, Jeremy, Peacock, Craig D., Bayles, Ian, Lovrenert, Katreya, Chin, Diana H., Gryder, Berkley E., Bartels, Cynthia F., Scacheri, Peter C.

“…The metastasis-invasion cascade describes the series of steps required for a cancer cell to successfully spread from its primary tumor and ultimately grow…”
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Mismatch repair-signature mutations activate gene enhancers across human colorectal cancer epigenomes by Hung, Stevephen, Saiakhova, Alina, Faber, Zachary J, Bartels, Cynthia F, Neu, Devin, Bayles, Ian, Ojo, Evelyn, Hong, Ellen S, Pontius, W Dean, Morton, Andrew R, Liu, Ruifu, Kalady, Matthew F, Wald, David N, Markowitz, Sanford, Scacheri, Peter C

“…Commonly-mutated genes have been found for many cancers, but less is known about mutations in cis-regulatory elements. We leverage gains in tumor-specific…”
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Ex vivo screen identifies CDK12 as a metastatic vulnerability in osteosarcoma by Bayles, Ian, Krajewska, Malgorzata, Pontius, W Dean, Saiakhova, Alina, Morrow, James J, Bartels, Cynthia, Lu, Jim, Faber, Zachary J, Fedorov, Yuriy, Hong, Ellen S, Karnuta, Jaret M, Rubin, Brian, Adams, Drew J, George, Rani E, Scacheri, Peter C

“…Despite progress in intensification of therapy, outcomes for patients with metastatic osteosarcoma (OS) have not improved in thirty years. We developed a…”
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HPV 5 and 8 E6 expression reduces ATM protein levels and attenuates LINE-1 retrotransposition by Wallace, Nicholas A, Gasior, Stephen L, Faber, Zachary J, Howie, Heather L, Deininger, Prescott L, Galloway, Denise A

“…Abstract The expression of the E6 protein from certain members of the HPV genus β (β HPV 5 and 8 E6) can disrupt p53 signaling by diminishing the steady state…”
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LINE-1 and Alu retrotransposition exhibit clonal variation by Streva, Vincent A, Faber, Zachary J, Deininger, Prescott L

“…The non-long terminal repeat (non-LTR) retrotransposons, long interspersed element-1 (LINE-1) and Alu are currently active retroelements in humans. We, and…”
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Incidence of Germline Mutations in Cancer-Predisposition Genes in Children with Hematologic Malignancies: a Report from the Pediatric Cancer Genome Project by Walsh, Michael, Wu, Gang, Edmonson, Michael, Gruber, Tanja A, Easton, John, Yergeau, Donald, Vadodaria, Bhavin, Ma, Xiaotu, Chen, Xiang, McGee, Rose, Odom, Christine, Shurtleff, Sheila A, Parker, Matthew, Rusch, Michael, Hedlund, Erin, Huether, Robert, Lemmon, Gordon, Nakitandwe, Joy, Becksfort, Jared, Nagahawatte, Panduka, Dong, Li, Gedman, Amanda Larson, Faber, Zachary J, Cheng, Jinjun, Dang, Jinjun, Pui, Ching-Hon, Nichols, Kim E, Gajjar, Amar, Ellison, David W, Pappo, Alberto, Mullighan, Charles G., Mardis, Elaine R, Wilson, Richard K, Zhang, Jinghui, Downing, James R

“…▪ Pathologic germ line mutations that predispose patients to cancer are estimated to occur in 4-30% of all pediatric oncology cases. In addition to leukemia…”
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Cellular control of human mobile elements by Faber, Zachary J

“…The human genome contains over 500,000 copies of the retrotransposon LINE-1. Although only a limited number remain active they still represent a potent source…”
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