Search Results - "Fabbrizio, Eric"

Notch inhibition overcomes resistance to tyrosine kinase inhibitors in EGFR-driven lung adenocarcinoma by Bousquet Mur, Emilie, Bernardo, Sara, Papon, Laura, Mancini, Maicol, Fabbrizio, Eric, Goussard, Marion, Ferrer, Irene, Giry, Anais, Quantin, Xavier, Pujol, Jean-Louis, Calvayrac, Olivier, Moll, Herwig P, Glasson, Yaël, Pirot, Nelly, Turtoi, Andrei, Cañamero, Marta, Wong, Kwok-Kin, Yarden, Yosef, Casanova, Emilio, Soria, Jean-Charles, Colinge, Jacques, Siebel, Christian W, Mazieres, Julien, Favre, Gilles, Paz-Ares, Luis, Maraver, Antonio

“…EGFR-mutated lung adenocarcinoma patients treated with gefitinib and osimertinib show a therapeutic benefit limited by the appearance of secondary mutations,…”
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PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome by Girardot, Michael, Hirasawa, Ryutaro, Kacem, Salim, Fritsch, Lauriane, Pontis, Julien, Kota, Satya K, Filipponi, Doria, Fabbrizio, Eric, Sardet, Claude, Lohmann, Felix, Kadam, Shilpa, Ait-Si-Ali, Slimane, Feil, Robert

“…Symmetrical dimethylation on arginine-3 of histone H4 (H4R3me2s) has been reported to occur at several repressed genes, but its specific regulation and genomic…”
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The histone-binding protein COPR5 is required for nuclear functions of the protein arginine methyltransferase PRMT5 by Lacroix, Matthieu, Messaoudi, Selma El, Rodier, Geneviève, Le Cam, Aphonse, Sardet, Claude, Fabbrizio, Eric

“…Protein arginine methyltransferase 5 (PRMT5) targets nuclear and cytoplasmic proteins. Here, we identified a nuclear protein, called cooperator of PRMT5…”
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Coactivator-Associated Arginine Methyltransferase 1 (CARM1) Is a Positive Regulator of the Cyclin E1 Gene by Messaoudi, Selma El, Fabbrizio, Eric, Rodriguez, Carmen, Chuchana, Paul, Fauquier, Lucas, Cheng, Donghang, Theillet, Charles, Vandel, Laurence, Bedford, Mark T., Sardet, Claude

“…The Cyclin El gene (CCNE1) is an ideal model to explore the mechanisms that control the transcription of cell cycle-regulated genes whose expression rises…”
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The Wnt-target gene Dlk-1 is regulated by the Prmt5-associated factor Copr5 during adipogenic conversion by Paul, Conception, Sardet, Claude, Fabbrizio, Eric

“…Protein arginine methyl transferase 5 (Prmt5) regulates various differentiation processes, including adipogenesis. Here, we investigated adipogenic conversion…”
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Negative regulation of transcription by the type II arginine methyltransferase PRMT5 by Fabbrizio, Eric, Messaoudi, Selma El, Polanowska, Jolanta, Paul, Conception, Cook, Jeffry R, Lee, Jin-Hyung, Nègre, Vincent, Rousset, Mathieu, Pestka, Sidney, Le Cam, Alphonse, Sardet, Claude

“…We have identified previously a repressor element in the transcription start site region of the cyclin E1 promoter that periodically associates with an…”
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The periodic down regulation of Cyclin E gene expression from exit of mitosis to end of G1 is controlled by a deacetylase- and E2F-associated bipartite repressor element by POLANOWSKA, Jolanta, FABBRIZIO, Eric, LE CAM, Laurent, TROUCHE, Didier, EMILIANI, Stephane, HERRERA, Raphael, SARDET, Claude

“…The expression of cyclin E and that of a few other bona fide cell cycle regulatory genes periodically oscillates every cycle in proliferating cells. Although…”
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Metastatic colorectal cancer cells maintain the TGFβ program and use TGFBI to fuel angiogenesis by Chiavarina, Barbara, Costanza, Brunella, Ronca, Roberto, Blomme, Arnaud, Rezzola, Sara, Chiodelli, Paola, Giguelay, Ambre, Belthier, Guillame, Doumont, Gilles, Van Simaeys, Gaetan, Lacroix, Simon, Yokobori, Takehiko, Erkhem-Ochir, Bilguun, Balaguer, Patrick, Cavailles, Vincent, Fabbrizio, Eric, Di Valentin, Emmanuel, Gofflot, Stephanie, Detry, Olivier, Jerusalem, Guy, Goldman, Serge, Delvenne, Philippe, Bellahcène, Akeila, Pannequin, Julie, Castronovo, Vincent, Turtoi, Andrei

“…Colorectal cancer (CRC) cells are traditionally considered unresponsive to TGFβ due to mutations in the receptors and/or downstream signaling molecules. TGFβ…”
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The mouse HP1 proteins are essential for preventing liver tumorigenesis by Saksouk, Nehmé, Hajdari, Shefqet, Perez, Yannick, Pratlong, Marine, Barrachina, Célia, Graber, Céline, Grégoire, Damien, Zavoriti, Aliki, Sarrazin, Amélie, Pirot, Nelly, Noël, Jean-Yohan, Khellaf, Lakhdar, Fabbrizio, Eric, Julien, Eric, Cammas, Florence M.

“…Chromatin organization is essential for appropriate interpretation of the genetic information. Here, we demonstrated that the chromatin-associated proteins HP1…”
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PXR Modulates the Prostate Cancer Cell Response to Afatinib by Regulating the Expression of the Monocarboxylate Transporter SLC16A1 by Matheux, Alice, Gassiot, Matthieu, Fromont, Gaëlle, Leenhardt, Fanny, Boulahtouf, Abdelhay, Fabbrizio, Eric, Marchive, Candice, Garcin, Aurélie, Agherbi, Hanane, Combès, Eve, Evrard, Alexandre, Houédé, Nadine, Balaguer, Patrick, Gongora, Céline, Mbatchi, Litaty C., Pourquier, Philippe

“…Resistance to castration is a crucial issue in the treatment of metastatic prostate cancer. Kinase inhibitors (KIs) have been tested as potential alternatives,…”
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pRB Binds to and Modulates the Transrepressing Activity of the E1A-Regulated Transcription Factor p120E4F by Fajas, Lluis, Paul, Conception, Zugasti, Olivier, Le Cam, Laurent, Polanowska, Jolanta, Fabbrizio, Eric, Medema, Rene, Vignais, Marie-Luce, Sardet, Claude

“…The retinoblastoma protein pRB is involved in the transcriptional control of genes essential for cell cycle progression and differentiation. pRB interacts with…”
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Coprs inactivation leads to a derepression of LINE1 transposons in spermatocytes by Paul, Conception, Delpech, Hélène, Haouzi, Delphine, Hamamah, Samir, Sardet, Claude, Fabbrizio, Eric

“…Repression of retrotransposons is essential for genome integrity during germ cell development and is tightly controlled through epigenetic mechanisms. In…”
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PRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G + C-rich regions of the mouse genome by Girardot, Michael, Hirasawa, Ryutaro, Kacem, Salim, Fritsch, Lauriane, Pontis, Julien, Kota, Satya, Filipponi, Doria, Fabbrizio, Eric, Sardet, Claude, Lohmann, Felix, Kadam, Shilpa, Ait-Si-Ali, Slimane, Feil, Robert

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Identification of the first Rho–GEF inhibitor, TRIPα, which targets the RhoA-specific GEF domain of Trio by Schmidt, Susanne, Diriong, Sylvie, Méry, Jean, Fabbrizio, Eric, Debant, Anne

“…The Rho–guanine nucleotide exchange factors (Rho–GEFs) remodel the actin cytoskeleton via their Rho–GTPase targets and affect numerous physiological processes…”
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Inhibition of mammalian cell proliferation by genetically selected peptide aptamers that functionally antagonize E2F activity by FABBRIZIO, E, LE CAM, L, POLANOWSKA, J, KACZOREK, M, LAMB, N, BRENT, R, SARDET, C

“…The p16-cyclin D-pRB-E2F pathway is frequently deregulated in human tumors. This critical regulatory pathway controls the G1/S transition of the mammalian cell…”
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Timing of cyclin E gene expression depends on the regulated association of a bipartite repressor element with a novel E2F complex by Le Cam, Laurent, Polanowska, Jolanta, Fabbrizio, Eric, Olivier, Magali, Philips, Alexandre, Ng Eaton, Eleonor, Classon, Marie, Geng, Yan, Sardet, Claude

“…Transient induction of the cyclin E gene in late G1 gates progression into S. We show that this event is controlled via a cyclin E repressor module (CERM), a…”
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Identification of the first Rho-GEF inhibitor, TRIPalpha, which targets the RhoA-specific GEF domain of Trio by Schmidt, Susanne, Diriong, Sylvie, Méry, Jean, Fabbrizio, Eric, Debant, Anne

“…The Rho-guanine nucleotide exchange factors (Rho-GEFs) remodel the actin cytoskeleton via their Rho-GTPase targets and affect numerous physiological processes…”
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Novel retinoid-related molecules as apoptosis inducers and effective inhibitors of human lung cancer cells in vivo by Lu, X P, Fanjul, A, Picard, N, Pfahl, M, Rungta, D, Nared-Hood, K, Carter, B, Piedrafita, J, Tang, S, Fabbrizio, E

“…Lung cancer causes more than 140,000 deaths annually in the United States alone, and the prognosis for non-small cell lung cancer (NSCLC) is particularly poor…”
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pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120(E4F) by Fajas, Lluis, Conception, Paul, Zugasti, Olivier, Laurent Le Cam

“…The retinoblastoma protein pRB is involved in the transcriptional control of genes essential for cell cycle progression and differentiation. pRB interacts with…”
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Human E2F5 gene is oncogenic in primary rodent cells and is amplified in human breast tumors by Polanowska, Jolanta, Le Cam, Laurent, Orsetti, Béatrice, Vallés, Heléne, Fabbrizio, Eric, Fajas, Lluis, Taviaux, Sylvie, Theillet, Charles, Sardet, Claude

“…E2F transcription factors (E2F1 to 6) are central players in the control of animal cell proliferation as regulators of genes involved in cell cycle progression…”
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