Search Results - "Fabbri, Muller"

MicroRNAs and miRceptors: a new mechanism of action for intercellular communication by Fabbri, Muller

“…MicroRNAs (miRs) are small non-coding RNAs (ncRNAs) that control the expression of target genes by modulating (usually inhibiting) their translation into…”
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TLRs as miRNA receptors by Fabbri, Muller

“…MicroRNAs (miRNA) are small noncoding RNAs with gene regulatory functions. Their expression is frequently dysregulated in almost all human tumors and they can…”
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Noncoding RNA therapeutics — challenges and potential solutions by Winkle, Melanie, El-Daly, Sherien M., Fabbri, Muller, Calin, George A.

“…Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), represents an attractive approach for the…”
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MicroRNAs and other non-coding RNAs as targets for anticancer drug development by Ling, Hui, Fabbri, Muller, Calin, George A.

“…Key Points Mature microRNAs (miRNAs) are single-stranded RNAs that are 19–24 nucleotides in length and are produced in a multistep process involving the…”
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Mechanisms of Drug Resistance in Cancer: The Role of Extracellular Vesicles by Samuel, Priya, Fabbri, Muller, Carter, David Raul Francisco

“…Drug resistance remains a major barrier to the successful treatment of cancer. The mechanisms by which therapeutic resistance arises are multifactorial. Recent…”
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Cancer-derived exosomic microRNAs shape the immune system within the tumor microenvironment: State of the art by Fanini, Francesca, Fabbri, Muller

“…In recent years there has been an increasing interest of the scientific community on exosome research, with particular emphasis on the mechanisms by which…”
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Essential role of miRNAs in orchestrating the biology of the tumor microenvironment by Frediani, Jamie N, Fabbri, Muller

“…MicroRNAs (miRNAs) are emerging as central players in shaping the biology of the Tumor Microenvironment (TME). They do so both by modulating their expression…”
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Natural Killer-Derived Exosomal miR-186 Inhibits Neuroblastoma Growth and Immune Escape Mechanisms by Neviani, Paolo, Wise, Petra M, Murtadha, Mariam, Liu, Cathy W, Wu, Chun-Hua, Jong, Ambrose Y, Seeger, Robert C, Fabbri, Muller

“…In neuroblastoma, the interplay between immune cells of the tumor microenvironment and cancer cells contributes to immune escape mechanisms and drug…”
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Cisplatin induces the release of extracellular vesicles from ovarian cancer cells that can induce invasiveness and drug resistance in bystander cells by Samuel, Priya, Mulcahy, Laura Ann, Furlong, Fiona, McCarthy, Helen O., Brooks, Susan Ann, Fabbri, Muller, Pink, Ryan Charles, Carter, David Raul Francisco

“…Ovarian cancer has a poor overall survival that is partly caused by resistance to drugs such as cisplatin. Resistance can be acquired as a result of changes to…”
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Overexpression of ultraconserved region 83- induces lung cancer tumorigenesis by Vannini, Ivan, Ferracin, Manuela, Fabbri, Francesco, Fabbri, Muller

“…The expression of non-coding RNAs (ncRNAs) is dysregulated in human cancers. The transcribed ultraconserved regions (T-UCRs) express long ncRNAs involved in…”
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MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response by Fabbri, Muller, Paone, Alessio, Calore, Federica, Galli, Roberta, Gaudio, Eugenio, Santhanam, Ramasamy, Lovat, Francesca, Fadda, Paolo, Mao, Charlene, Nuovo, Gerard J, Zanesi, Nicola, Crawford, Melissa, Ozer, Gulcin H, Wernicke, Dorothee, Alder, Hansjuerg, Caligiuri, Michael A, Nana-Sinkam, Patrick, Perrotti, Danilo, Croce, Carlo M

“…MicroRNAs (miRNAs) are small noncoding RNAs, 19–24 nucleotides in length, that regulate gene expression and are expressed aberrantly in most types of cancer…”
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Exosome-mediated transfer of microRNAs within the tumor microenvironment and neuroblastoma resistance to chemotherapy by Challagundla, Kishore B, Wise, Petra M, Neviani, Paolo, Chava, Haritha, Murtadha, Mariam, Xu, Tong, Kennedy, Rebekah, Ivan, Cristina, Zhang, Xinna, Vannini, Ivan, Fanini, Francesca, Amadori, Dino, Calin, George A, Hadjidaniel, Michael, Shimada, Hiroyuki, Jong, Ambrose, Seeger, Robert C, Asgharzadeh, Shahab, Goldkorn, Amir, Fabbri, Muller

“…How exosomic microRNAs (miRNAs) contribute to the development of drug resistance in the context of the tumor microenvironment has not been previously described…”
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Exosomal MicroRNAs in Breast Cancer towards Diagnostic and Therapeutic Applications by Sempere, Lorenzo F, Keto, Jessica, Fabbri, Muller

“…Soon after the discovery of microRNAs over 15 years ago, a myriad of research groups around the world sought to develop clinical applications in breast cancer…”
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MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2) by Valeri, Nicola, Gasparini, Pierluigi, Braconi, Chiara, Paone, Alessio, Lovat, Francesca, Fabbri, Muller, Sumani, Khlea M., Alder, Hansjuerg, Amadori, Dino, Patel, Tushar, Nuovo, Gerard J., Fishel, Richard, Croce, Carlo M.

“…The overexpression of microRNA-21 (miR-21) is linked to a number of human tumors including colorectal cancer, where it appears to regulate the expression of…”
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MicroRNA-135b Promotes Cancer Progression by Acting as a Downstream Effector of Oncogenic Pathways in Colon Cancer by Valeri, Nicola, Braconi, Chiara, Gasparini, Pierluigi, Murgia, Claudio, Lampis, Andrea, Paulus-Hock, Viola, Hart, Jonathan R., Ueno, Lynn, Grivennikov, Sergei I., Lovat, Francesca, Paone, Alessio, Cascione, Luciano, Sumani, Khlea M., Veronese, Angelo, Fabbri, Muller, Carasi, Stefania, Alder, Hansjuerg, Lanza, Giovanni, Gafa’, Roberta, Moyer, Mary P., Ridgway, Rachel A., Cordero, Julia, Nuovo, Gerard J., Frankel, Wendy L., Rugge, Massimo, Fassan, Matteo, Groden, Joanna, Vogt, Peter K., Karin, Michael, Sansom, Owen J., Croce, Carlo M.

“…MicroRNA deregulation is frequent in human colorectal cancers (CRCs), but little is known as to whether it represents a bystander event or actually drives…”
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Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers by Van Roosbroeck, Katrien, Fanini, Francesca, Setoyama, Tetsuro, Ivan, Cristina, Rodriguez-Aguayo, Cristian, Fuentes-Mattei, Enrique, Xiao, Lianchun, Vannini, Ivan, Redis, Roxana S, D'Abundo, Lucilla, Zhang, Xinna, Nicoloso, Milena S, Rossi, Simona, Gonzalez-Villasana, Vianey, Rupaimoole, Rajesha, Ferracin, Manuela, Morabito, Fortunato, Neri, Antonino, Ruvolo, Peter P, Ruvolo, Vivian R, Pecot, Chad V, Amadori, Dino, Abruzzo, Lynne, Calin, Steliana, Wang, Xuemei, You, M James, Ferrajoli, Alessandra, Orlowski, Robert, Plunkett, William, Lichtenberg, Tara M, Davuluri, Ramana V, Berindan-Neagoe, Ioana, Negrini, Massimo, Wistuba, Ignacio I, Kantarjian, Hagop M, Sood, Anil K, Lopez-Berestein, Gabriel, Keating, Michael J, Fabbri, Muller, Calin, George A

“…The oncogenic miR-155 is upregulated in many human cancers, and its expression is increased in more aggressive and therapy-resistant tumors, but the molecular…”
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Biological roles and potential applications of immune cell-derived extracellular vesicles by Wen, Chuan, Seeger, Robert C., Fabbri, Muller, Wang, Larry, Wayne, Alan S., Jong, Ambrose Y.

“…Extracellular vesicles (EVs) deliver bioactive macromolecules (i.e. proteins, lipids and nucleic acids) for intercellular communication in multicellular…”
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Extracellular vesicles derived from natural killer cells use multiple cytotoxic proteins and killing mechanisms to target cancer cells by Wu, Chun-Hua, Li, Jingbo, Li, Li, Sun, Jianping, Fabbri, Muller, Wayne, Alan S., Seeger, Robert C., Jong, Ambrose Y.

“…Extracellular vesicles (EVs) are secreted membrane vesicles, which play complex physiological and pathological functions in intercellular communication…”
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MicroRNA 29b functions in acute myeloid leukemia by Garzon, Ramiro, Heaphy, Catherine E.A., Havelange, Violaine, Fabbri, Muller, Volinia, Stefano, Tsao, Twee, Zanesi, Nicola, Kornblau, Steven M., Marcucci, Guido, Calin, George A., Andreeff, Michael, Croce, Carlo M.

“…MicroRNAs (miRNAs) are associated with cytogenetics and molecular subtypes of acute myelogeneous leukemia (AML), but their impact on AML pathogenesis is poorly…”
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Large-scale isolation and cytotoxicity of extracellular vesicles derived from activated human natural killer cells by Jong, Ambrose Y., Wu, Chun-Hua, Li, Jingbo, Sun, Jianping, Fabbri, Muller, Wayne, Alan S., Seeger, Robert C.

“…Extracellular vesicles (EVs) have been the focus of great interest, as they appear to be involved in numerous important cellular processes. They deliver…”
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