Search Results - "Fabíola M. Ribeiro"
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Synaptic Elimination in Neurological Disorders
Published in Current neuropharmacology (01-01-2019)“…Synapses are well known as the main structures responsible for transmitting information through the release and recognition of neurotransmitters by pre- and…”
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The Implication of Glial Metabotropic Glutamate Receptors in Alzheimer's Disease
Published in Current neuropharmacology (01-02-2023)“…Alzheimer's disease (AD) was first identified more than 100 years ago, yet aspects pertaining to its origin and the mechanisms underlying disease progression…”
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Protective role of endocannabinoid signaling in an animal model of haloperidol-induced tardive dyskinesia
Published in Pharmacology, biochemistry and behavior (01-07-2021)“…Tardive dyskinesia (TD) is a side effect associated with the long-term use of certain antipsychotics. Considering the modulatory role of the endocannabinoid…”
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Estradiol enhances object recognition memory in Swiss female mice by activating hippocampal estrogen receptor α
Published in Neurobiology of learning and memory (01-10-2014)“…•Estradiol acts as a cognitive enhancer in Swiss female mice.•ERα is the receptor activated by E2 into the hippocampus of Swiss female mice to improve object…”
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Estradiol effect on short-term object memory under hypocholinergic condition
Published in Brain research bulletin (01-06-2018)“…•Estradiol recovers short-term object recognition memory deficit of VAChT KD male mice and OVX VAChT KD female mice.•Hippocampal ERα activation recovers memory…”
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Thiamine Deficiency Increases Ca2+ Current and CaV1.2 L-type Ca2+ Channel Levels in Cerebellum Granular Neurons
Published in Cellular and molecular neurobiology (01-04-2017)“…Thiamine (vitamin B1) is co-factor for three pivotal enzymes for glycolytic metabolism: pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, and…”
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Alzheimer's disease: Targeting the Cholinergic System
Published in Current neuropharmacology (01-01-2016)“…Acetylcholine (ACh) has a crucial role in the peripheral and central nervous systems. The enzyme choline acetyltransferase (ChAT) is responsible for…”
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Metabotropic glutamate receptors and neurodegenerative diseases
Published in Pharmacological research (01-01-2017)“…[Display omitted] Glutamate is the most important excitatory neurotransmitter of the mammalian central nervous system (CNS), playing an important role in…”
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SEC14-like protein 1 interacts with cholinergic transporters
Published in Neurochemistry international (2007)“…Trafficking of the vesicular acetylcholine transporter (VAChT) to synaptic vesicles has the potential to regulate storage and release of acetylcholine. We used…”
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Group I metabotropic glutamate receptor signalling and its implication in neurological disease
Published in CNS & neurological disorders drug targets (01-11-2010)“…Stimulation of Group I metabotropic glutamate receptors (mGluR1 and mGluR5) leads to activation of a wide variety of signalling pathways. mGluRs couple to…”
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Neuroimmunology of Huntington’s Disease: Revisiting Evidence from Human Studies
Published in Mediators of inflammation (01-01-2016)“…Huntington’s disease (HD) is a neurodegenerative disorder characterized by selective loss of neurons in the striatum and cortex, which leads to progressive…”
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Animal Toxins as Therapeutic Tools to Treat Neurodegenerative Diseases
Published in Frontiers in pharmacology (23-02-2018)“…Neurodegenerative diseases affect millions of individuals worldwide. So far, no disease-modifying drug is available to treat patients, making the search for…”
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Zika Virus Transmission Through Blood Tissue Barriers
Published in Frontiers in microbiology (04-07-2019)“…The recent Zika virus (ZIKV) epidemic in the Americas and the Caribbean revealed a new deadly strain of the mosquito-borne virus, which has never been…”
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mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington’s disease
Published in Molecular brain (28-08-2020)“…Repressor element 1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) is a transcription repressor and its expression is regulated…”
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Blockade of mGluR5 in astrocytes derived from human iPSCs modulates astrocytic function and increases phagocytosis
Published in Frontiers in immunology (11-12-2023)“…TNF-α is essential for induction and maintenance of inflammatory responses and its dysregulation is associated with susceptibility to various pathogens that…”
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Zika Virus Promotes Neuronal Cell Death in a Non-Cell Autonomous Manner by Triggering the Release of Neurotoxic Factors
Published in Frontiers in immunology (23-08-2017)“…Zika virus (ZIKV) has recently caused a worldwide outbreak of infections associated with severe neurological complications, including microcephaly in infants…”
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mGluR5 ablation leads to age-related synaptic plasticity impairments and does not improve Huntington’s disease phenotype
Published in Scientific reports (28-05-2022)“…Glutamate receptors, including mGluR5, are involved in learning and memory impairments triggered by aging and neurological diseases. However, each condition…”
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Rab8 modulates metabotropic glutamate receptor subtype 1 intracellular trafficking and signaling in a protein kinase C-dependent manner
Published in The Journal of neuroscience (21-11-2012)“…Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors (GPCRs) that are activated by glutamate, the primary excitatory neurotransmitter in…”
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Enhancement of endocannabinoid signaling protects against cocaine-induced neurotoxicity
Published in Toxicology and applied pharmacology (01-08-2015)“…Cocaine is an addictive substance with a potential to cause deleterious effects in the brain. The strategies for treating its neurotoxicity, however, are…”
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Metabotropic Glutamate Receptor-Mediated Cell Signaling Pathways Are Altered in a Mouse Model of Huntington's Disease
Published in The Journal of neuroscience (06-01-2010)“…Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by a polyglutamine expansion in the huntingtin protein (Htt). Group I…”
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