Search Results - "Faakye, Janet"

Accelerated cerebromicrovascular senescence contributes to cognitive decline in a mouse model of paclitaxel (Taxol)‐induced chemobrain by Ahire, Chetan, Nyul‐Toth, Adam, DelFavero, Jordan, Gulej, Rafal, Faakye, Janet A., Tarantini, Stefano, Kiss, Tamas, Kuan‐Celarier, Anna, Balasubramanian, Priya, Ungvari, Anna, Tarantini, Amber, Nagaraja, Raghavendra, Yan, Feng, Tang, Qinggong, Mukli, Peter, Csipo, Tamas, Yabluchanskiy, Andriy, Campisi, Judith, Ungvari, Zoltan, Csiszar, Anna

“…Chemotherapy‐induced cognitive impairment (“chemobrain”) is a frequent side‐effect in cancer survivors treated with paclitaxel (PTX). The mechanisms…”
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Spatial transcriptomic analysis reveals inflammatory foci defined by senescent cells in the white matter, hippocampi and cortical grey matter in the aged mouse brain by Kiss, Tamas, Nyúl-Tóth, Ádám, DelFavero, Jordan, Balasubramanian, Priya, Tarantini, Stefano, Faakye, Janet, Gulej, Rafal, Ahire, Chetan, Ungvari, Anna, Yabluchanskiy, Andriy, Wiley, Graham, Garman, Lori, Ungvari, Zoltan, Csiszar, Anna

“…There is strong evidence that aging is associated with an increased presence of senescent cells in the brain. The finding that treatment with senolytic drugs…”
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Cerebral venous congestion exacerbates cerebral microhemorrhages in mice by Nyul-Toth, Adam, Fulop, Gabor A., Tarantini, Stefano, Kiss, Tamas, Ahire, Chetan, Faakye, Janet A., Ungvari, Anna, Toth, Peter, Toth, Attila, Csiszar, Anna, Ungvari, Zoltan

“…Cerebral microhemorrhages (CMHs; microbleeds), which are small focal intracerebral hemorrhages, importantly contribute to the pathogenesis of cognitive decline…”
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Rejuvenation of cerebromicrovascular function in aged mice through heterochronic parabiosis: insights into neurovascular coupling and the impact of young blood factors by Gulej, Rafal, Nyúl-Tóth, Ádám, Csik, Boglarka, Petersen, Benjamin, Faakye, Janet, Negri, Sharon, Chandragiri, Siva Sai, Mukli, Peter, Yabluchanskiy, Andriy, Conley, Shannon, Huffman, Derek M., Csiszar, Anna, Tarantini, Stefano, Ungvari, Zoltan

“…Age-related impairment of neurovascular coupling (NVC; “functional hyperemia”) is a critical factor in the development of vascular cognitive impairment (VCI)…”
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Preventing spontaneous cerebral microhemorrhages in aging mice: a novel approach targeting cellular senescence with ABT263/navitoclax by Faakye, Janet, Nyúl-Tóth, Ádám, Muranyi, Mihaly, Gulej, Rafal, Csik, Boglarka, Shanmugarama, Santny, Tarantini, Stefano, Negri, Sharon, Prodan, Calin, Mukli, Peter, Yabluchanskiy, Andriy, Conley, Shannon, Toth, Peter, Csiszar, Anna, Ungvari, Zoltan

“…Emerging evidence from both clinical and preclinical studies underscores the role of aging in potentiating the detrimental effects of hypertension on cerebral…”
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Imaging the time course, morphology, neuronal tissue compression, and resolution of cerebral microhemorrhages in mice using intravital two-photon microscopy: insights into arteriolar, capillary, and venular origin by Faakye, Janet, Nyúl-Tóth, Ádám, Gulej, Rafal, Csik, Boglarka, Tarantini, Stefano, Shanmugarama, Santny, Prodan, Calin, Mukli, Peter, Yabluchanskiy, Andriy, Conley, Shannon, Toth, Peter, Csiszar, Anna, Ungvari, Zoltan

“…Cerebral microhemorrhages (CMHs, microbleeds), a manifestation of age-related cerebral small vessel disease, contribute to the pathogenesis of cognitive…”
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Endothelial deficiency of insulin‐like growth factor‐1 receptor leads to blood–brain barrier disruption and accelerated endothelial senescence in mice, mimicking aspects of the brain aging phenotype by Gulej, Rafal, Csik, Boglarka, Faakye, Janet, Tarantini, Stefano, Shanmugarama, Santny, Chandragiri, Siva Sai, Mukli, Peter, Conley, Shannon, Csiszar, Anna, Ungvari, Zoltan, Yabluchanskiy, Andriy, Nyúl‐Tóth, Ádám

“…Introduction Age‐related blood–brain barrier (BBB) disruption, cerebromicrovascular senescence, and microvascular rarefaction substantially contribute to the…”
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Age-Related Cerebral Microhemorrhages: Prevention and Morphologies by Faakye, Janet Asiedua

“…Cerebral microhemorrhages (CMHs; microbleeds), which are small intracerebral hemorrhages, contribute significantly to the pathogenesis of cognitive decline and…”
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Temporary opening of the blood-brain barrier with the nitrone compound OKN-007 by Towner, Rheal A, Saunders, Debra, Lerner, Megan, Silasi Mansat, Robert, Yuan, Tian, Barber, Dylan, Faakye, Janet, Nyul-Toth, Adam, Csiszar, Anna, Greenwood-Van Meerveld, Beverley, Smith, Nataliya

“…The blood-brain barrier (BBB) is usually impermeable to several drugs, which hampers treatment of various brain-related diseases/disorders. There have been…”
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