Search Results - "Faß, M."

Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease by Kilgore, Mark, Miller, Courtney A, Fass, Daniel M, Hennig, Krista M, Haggarty, Stephen J, Sweatt, J David, Rumbaugh, Gavin

“…Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by cognitive impairments that progress to dementia and death. The earliest…”
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Dysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder by Bavamian, S, Mellios, N, Lalonde, J, Fass, D M, Wang, J, Sheridan, S D, Madison, J M, Zhou, Fen, Rueckert, E H, Barker, D, Perlis, R H, Sur, M, Haggarty, S J

“…Bipolar disorder (BD) is a heritable neuropsychiatric disorder with largely unknown pathogenesis. Given their prominent role in brain function and disease, we…”
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Antidepressant Actions of Histone Deacetylase Inhibitors by Covington, Herbert E., III, Maze, Ian, LaPlant, Quincey C, Vialou, Vincent F, Ohnishi, Yoshinori N, Berton, Olivier, Fass, Dan M, Renthal, William, Rush, Augustus J., III, Wu, Emma Y, Ghose, Subroto, Krishnan, Vaishnav, Russo, Scott J, Tamminga, Carol, Haggarty, Stephen J, Nestler, Eric J

“…Persistent symptoms of depression suggest the involvement of stable molecular adaptations in brain, which may be reflected at the level of chromatin…”
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Laser welding of 16MnCr5 butt welds with gap: resulting weld quality and fatigue strength assessment by Hensel, J., Köhler, M., Uhlenberg, L., Castro, J. Diniz e, Dilger, K., Faß, M., Baumgartner, J.

“…For laser welding, gaps should normally be avoided to ensure stable weld processes and high weld quality. Nonetheless, sometimes, gaps are resulting from…”
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Benzoxazole-derivatives enhance progranulin expression and reverse the aberrant lysosomal proteome caused by GRN haploinsufficiency by Tesla, Rachel, Guhl, Charlotte, Werthmann, Gordon C., Dixon, Danielle, Cenik, Basar, Addepalli, Yesu, Liang, Jue, Fass, Daniel M., Rosenthal, Zachary, Haggarty, Stephen J., Williams, Noelle S., Posner, Bruce A., Ready, Joseph M., Herz, Joachim

“…Heterozygous loss-of-function mutations in the GRN gene are a major cause of hereditary frontotemporal dementia. The mechanisms linking frontotemporal dementia…”
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Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia by Rosenthal, Zachary C., Fass, Daniel M., Payne, N. Connor, She, Angela, Patnaik, Debasis, Hennig, Krista M., Tesla, Rachel, Werthmann, Gordon C., Guhl, Charlotte, Reis, Surya A., Wang, Xiaoyu, Chen, Yueting, Placzek, Michael, Williams, Noelle S., Hooker, Jacob, Herz, Joachim, Mazitschek, Ralph, Haggarty, Stephen J.

“…Frontotemporal dementia (FTD) is a debilitating neurodegenerative disorder with currently no disease-modifying treatment options available. Mutations in GRN…”
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Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1–PAK3 signaling in neuroplasticity by Kim, M J, Biag, J, Fass, D M, Lewis, M C, Zhang, Q, Fleishman, M, Gangwar, S P, Machius, M, Fromer, M, Purcell, S M, McCarroll, S A, Rudenko, G, Premont, R T, Scolnick, E M, Haggarty, S J

“…Although the pathogenesis of schizophrenia (SCZ) is proposed to involve alterations of neural circuits via synaptic dysfunction, the underlying molecular…”
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Enhancing physical characteristics and antibacterial efficacy of chitosan through investigation of microwave-assisted chemically formulated chitosan-coated ZnO and chitosan/ZnO physical composite by Ali, Sara A., Ali, E. S., Hamdy, G., Badawy, Mona Shaban E. M., Ismail, Abdallah R., El-Sabbagh, Inas. A., El-Fass, Magda M., Elsawy, Moataz A.

“…This study investigates the creation and analysis of chitosan-zinc oxide (CS-ZnO) nanocomposites, exploring their effectiveness in inhibiting bacteria. Two…”
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An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors by Marcaurelle, Lisa A, Comer, Eamon, Dandapani, Sivaraman, Duvall, Jeremy R, Gerard, Baudouin, Kesavan, Sarathy, Lee, Maurice D, Liu, Haibo, Lowe, Jason T, Marie, Jean-Charles, Mulrooney, Carol A, Pandya, Bhaumik A, Rowley, Ann, Ryba, Troy D, Suh, Byung-Chul, Wei, Jingqiang, Young, Damian W, Akella, Lakshmi B, Ross, Nathan T, Zhang, Yan-Ling, Fass, Daniel M, Reis, Surya A, Zhao, Wen-Ning, Haggarty, Stephen J, Palmer, Michelle, Foley, Michael A

“…An aldol-based build/couple/pair (B/C/P) strategy was applied to generate a collection of stereochemically and skeletally diverse small molecules. In the build…”
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High-content image-based analysis and proteomic profiling identifies Tau phosphorylation inhibitors in a human iPSC-derived glutamatergic neuronal model of tauopathy by Cheng, Chialin, Reis, Surya A., Adams, Emily T., Fass, Daniel M., Angus, Steven P., Stuhlmiller, Timothy J., Richardson, Jared, Olafson, Hailey, Wang, Eric T., Patnaik, Debasis, Beauchamp, Roberta L., Feldman, Danielle A., Silva, M. Catarina, Sur, Mriganka, Johnson, Gary L., Ramesh, Vijaya, Miller, Bruce L., Temple, Sally, Kosik, Kenneth S., Dickerson, Bradford C., Haggarty, Stephen J.

“…Mutations in MAPT (microtubule-associated protein tau) cause frontotemporal dementia (FTD). MAPT mutations are associated with abnormal tau phosphorylation…”
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Kinetically Selective Inhibitors of Histone Deacetylase 2 (HDAC2) as Cognition Enhancers by Wagner, F F, Zhang, Y-L, Fass, D M, Joseph, N, Gale, J P, Weïwer, M, McCarren, P, Fisher, S L, Kaya, T, Zhao, W-N, Reis, S A, Hennig, K M, Thomas, M, Lemercier, B C, Lewis, M C, Guan, J S, Moyer, M P, Scolnick, E, Haggarty, S J, Tsai, L-H, Holson, E B

“…Aiming towards the development of novel nootropic therapeutics to address the cognitive impairment common to a range of brain disorders, we set out to develop…”
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Class I Histone Deacetylase Inhibition by Tianeptinaline Modulates Neuroplasticity and Enhances Memory by Zhao, Wen-Ning, Ghosh, Balaram, Tyler, Marshall, Lalonde, Jasmin, Joseph, Nadine F, Kosaric, Nina, Fass, Daniel M, Tsai, Li-Huei, Mazitschek, Ralph, Haggarty, Stephen J

“…Through epigenetic and other regulatory functions, the histone deacetylase (HDAC) family of enzymes has emerged as a promising therapeutic target for central…”
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Epigenetic mechanisms in mood disorders: Targeting neuroplasticity by Fass, D.M, Schroeder, F.A, Perlis, R.H, Haggarty, S.J

“…Graphical abstract Highlights ► Molecular mechanisms of mood disorders involving altered neuroplasticity. ► Epigenetic mechanisms play a critical role in the…”
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Phosphorylation of CBP Mediates Transcriptional Activation by Neural Activity and CaM Kinase IV by Impey, Soren, Fong, Amy L., Wang, Yanhong, Cardinaux, Jean-Rene, Fass, Daniel M., Obrietan, Karl, Wayman, Gary A., Storm, Daniel R., Soderling, Thomas R., Goodman, Richard H.

“…Activity-regulated transcription has been implicated in adaptive plasticity in the CNS. In many instances, this plasticity depends upon the transcription…”
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Deacetylase Activity Is Required for cAMP Activation of a Subset of CREB Target Genes by Fass, Daniel M., Butler, Jennifer E.F., Goodman, Richard H.

“…Many hormones activate transcription by raising the level of cAMP within cells. In one well studied pathway, cAMP induces protein kinase A to phosphorylate the…”
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Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice by Kovalenko, Marina, Erdin, Serkan, Andrew, Marissa A, St Claire, Jason, Shaughnessey, Melissa, Hubert, Leroy, Neto, João Luís, Stortchevoi, Alexei, Fass, Daniel M, Mouro Pinto, Ricardo, Haggarty, Stephen J, Wilson, John H, Talkowski, Michael E, Wheeler, Vanessa C

“…Somatic expansion of the Huntington's disease (HD) CAG repeat drives the rate of a pathogenic process ultimately resulting in neuronal cell death. Although…”
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Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities by Madison, J M, Zhou, F, Nigam, A, Hussain, A, Barker, D D, Nehme, R, van der Ven, K, Hsu, J, Wolf, P, Fleishman, M, O'Dushlaine, C, Rose, S, Chambert, K, Lau, F H, Ahfeldt, T, Rueckert, E H, Sheridan, S D, Fass, D M, Nemesh, J, Mullen, T E, Daheron, L, McCarroll, S, Sklar, P, Perlis, R H, Haggarty, S J

“…Bipolar disorder (BD) is a common neuropsychiatric disorder characterized by chronic recurrent episodes of depression and mania. Despite evidence for high…”
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Short-Chain HDAC Inhibitors Differentially Affect Vertebrate Development and Neuronal Chromatin by Fass, Daniel M, Shah, Rishita, Ghosh, Balaram, Hennig, Krista, Norton, Stephanie, Zhao, Wen-Ning, Reis, Surya A, Klein, Peter S, Mazitschek, Ralph, Maglathlin, Rebecca L, Lewis, Timothy A, Haggarty, Stephen J

“…Carboxylic acids with known central nervous system and histone deacetylase (HDAC) inhibitory activities were converted to hydroxamic acids and tested using a…”
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The DNA damage mark pH2AX differentiates the cytotoxic effects of small molecule HDAC inhibitors in ovarian cancer cells by Wilson, Andrew J., Holson, Edward, Wagner, Florence, Zhang, Yan-Ling, Fass, Daniel M., Haggarty, Stephen J., Bhaskara, Srividya, Hiebert, Scott W., Schreiber, Stuart L., Khabele, Dineo

“…High grade epithelial ovarian cancers are relatively sensitive to DNA damaging platinum-based chemotherapy, suggesting that the dependencies of ovarian tumors…”
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A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests by Schroeder, Frederick A, Lewis, Michael C, Fass, Daniel M, Wagner, Florence F, Zhang, Yan-Ling, Hennig, Krista M, Gale, Jennifer, Zhao, Wen-Ning, Reis, Surya, Barker, Douglas D, Berry-Scott, Erin, Kim, Sung Won, Clore, Elizabeth L, Hooker, Jacob M, Holson, Edward B, Haggarty, Stephen J, Petryshen, Tracey L

“…Psychiatric diseases, including schizophrenia, bipolar disorder and major depression, are projected to lead global disease burden within the next decade…”
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