Search Results - "FUSTER, MARK"

Integrating electromagnetic cancer stress with immunotherapy: a therapeutic paradigm by Fuster, Mark M

“…An array of published cell-based and small animal studies have demonstrated a variety of exposures of cancer cells or experimental carcinomas to…”
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Characterization of heparin and severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) spike glycoprotein binding interactions by Kim, So Young, Jin, Weihua, Sood, Amika, Montgomery, David W., Grant, Oliver C., Fuster, Mark M., Fu, Li, Dordick, Jonathan S., Woods, Robert J., Zhang, Fuming, Linhardt, Robert J.

“…Severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) has resulted in a pandemic and continues to spread around the globe at an unprecedented…”
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The sweet and sour of cancer: glycans as novel therapeutic targets by Esko, Jeffrey D, Fuster, Mark M

“…A growing body of evidence supports crucial roles for glycans at various pathophysiological steps of tumour progression. Glycans regulate tumour proliferation,…”
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The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions by Dyer, Douglas P., Salanga, Catherina L., Johns, Scott C., Valdambrini, Elena, Fuster, Mark M., Milner, Caroline M., Day, Anthony J., Handel, Tracy M.

“…TNF-stimulated gene-6 (TSG-6) is a multifunctional protein secreted in response to pro-inflammatory stimuli by a wide range of cells, including neutrophils,…”
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Glycocalyx transduces membrane leak in brain tumor cells exposed to sharp magnetic pulsing by Johns, Scott C, Gupta, Purva, Lee, Yi-Hung, Friend, James, Fuster, Mark M

“…Mechanisms by which electric (E) or magnetic (B) fields might be harnessed to affect tumor cell behavior remain poorly defined, presenting a barrier to…”
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Pulsed Low-Frequency Magnetic Fields Induce Tumor Membrane Disruption and Altered Cell Viability by Ashdown, Christopher P., Johns, Scott C., Aminov, Edward, Unanian, Michael, Connacher, William, Friend, James, Fuster, Mark M.

“…Tumor cells express a unique cell surface glycocalyx with upregulation of sulfated glycosaminoglycans and charged glycoproteins. Little is known about how…”
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Heparan Sulfate Regulates VEGF165- and VEGF121-mediated Vascular Hyperpermeability by Xu, Ding, Fuster, Mark M., Lawrence, Roger, Esko, Jeffrey D.

“…VEGF was first described as vascular permeability factor, a potent inducer of vascular leakage. Genetic evidence indicates that VEGF-stimulated endothelial…”
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Targeting glycan sulfation in a CD11c+ myeloid population inhibits early KRAS-mutant lung neoplasia by Kim, So Young, Johns, Scott C., Gupta, Purva, Varki, Nissi, Fuster, Mark M

“…Early lung carcinoma development may be modulated by innate host cellular mechanisms that promote tumor growth and invasion. We recently identified how a…”
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Ventilator-induced lung injury increases expression of endothelial inflammatory mediators in the kidney by Hepokoski, Mark, Englert, Joshua A, Baron, Rebecca M, Crotty-Alexander, Laura E, Fuster, Mark M, Beitler, Jeremy R, Malhotra, Atul, Singh, Prabhleen

“…In critical illness, such as sepsis or the acute respiratory distress syndrome, acute kidney injury (AKI) is common and associated with increased morbidity and…”
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Effects of curative-intent lung cancer therapy on functional exercise capacity and patient-reported outcomes by Ha, Duc, Ries, Andrew L., Lippman, Scott M., Fuster, Mark M.

“…Purpose Lung cancer treatment can lead to negative health consequences. We analyzed the effects of curative-intent lung cancer treatment on functional exercise…”
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Genetic alteration of heparan sulfate in CD11c + immune cells inhibits inflammation and facilitates pathogen clearance during influenza A virus infection by Kim, So Young, Gupta, Purva, Johns, Scott C., Zuniga, Elina I., Teijaro, John R., Fuster, Mark M.

“…Survival from influenza A virus (IAV) infection largely depends on an intricate balance between pathogen clearance and immunomodulation in the lung. We…”
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Exercise capacity and cancer-specific quality of life following curative intent treatment of stage I–IIIA lung cancer by Ha, Duc, Ries, Andrew L., Mazzone, Peter J., Lippman, Scott M., Fuster, Mark M.

“…Purpose Lung cancer survivors are at risk for health impairments resulting from the effects and/or treatment of lung cancer and comorbidities. Practical…”
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Time to treatment and survival in veterans with lung cancer eligible for curative intent therapy by Ha, Duc, Ries, Andrew L., Montgrain, Philippe, Vaida, Florin, Sheinkman, Svetlana, Fuster, Mark M.

“…The Institute of Medicine emphasizes care timeliness as an important quality metric. We assessed treatment timeliness in stage I-IIIA lung cancer patients…”
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A Model-Based Cost-Effectiveness Analysis of an Exercise Program for Lung Cancer Survivors After Curative-Intent Treatment by Ha, Duc, Kerr, Jacqueline, Ries, Andrew L., Fuster, Mark M., Lippman, Scott M., Murphy, James D.

“…OBJECTIVEThe cost-effectiveness of exercise interventions in lung cancer survivors is unknown. We performed a model-based cost-effectiveness analysis of an…”
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Functional Cellular Anti-Tumor Mechanisms are Augmented by Genetic Proteoglycan Targeting by Gupta, Purva, Johns, Scott C., Kim, So Young, El Ghazal, Roland, Zuniga, Elina I., Fuster, Mark M.

“…While recent research points to the importance of glycans in cancer immunity, knowledge on functional mechanisms is lacking. In lung carcinoma among other…”
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Functional Importance of a Proteoglycan Coreceptor in Pathologic Lymphangiogenesis by Johns, Scott C, Yin, Xin, Jeltsch, Michael, Bishop, Joseph R, Schuksz, Manuela, El Ghazal, Roland, Wilcox-Adelman, Sarah A, Alitalo, Kari, Fuster, Mark M

“…RATIONALE:Lymphatic vessel growth is mediated by major prolymphangiogenic factors, such as vascular endothelial growth factor (VEGF-C) and VEGF-D, among other…”
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Heart rate variability and heart rate recovery in lung cancer survivors eligible for long-term cure by Ha, Duc, Malhotra, Atul, Ries, Andrew L., O’Neal, Wesley T., Fuster, Mark M.

“…•HRV and HRR were impaired in 59% and 65% of lung cancer survivors, respectively.•Predictors of HRR were age and change in HR associated with exercise…”
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Surfen, a small molecule antagonist of heparan sulfate by Schuksz, Manuela, Fuster, Mark M, Brown, Jillian R, Crawford, Brett E, Ditto, David P, Lawrence, Roger, Glass, Charles A, Wang, Lianchun, Tor, Yitzhak, Esko, Jeffrey D

“…In a search for small molecule antagonists of heparan sulfate, we examined the activity of bis-2-methyl-4-amino-quinolyl-6-carbamide, also known as surfen…”
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Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth by El Ghazal, Roland, Yin, Xin, Johns, Scott C, Swanson, Lee, Macal, Monica, Ghosh, Pradipta, Zuniga, Elina I, Fuster, Mark M

“…Abstract In cancer, proteoglycans have been found to play roles in facilitating the actions of growth factors, and effecting matrix invasion and remodeling…”
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A general method for site specific fluorescent labeling of recombinant chemokines by Kawamura, Tetsuya, Stephens, Bryan, Qin, Ling, Yin, Xin, Dores, Michael R, Smith, Thomas H, Grimsey, Neil, Abagyan, Ruben, Trejo, Joann, Kufareva, Irina, Fuster, Mark M, Salanga, Catherina L, Handel, Tracy M

“…Chemokines control cell migration in many contexts including development, homeostasis, immune surveillance and inflammation. They are also involved in a wide…”
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