Search Results - "FUSENIG, N"

Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization by Bajou, K, Noël, A, Gerard, R.D, Masson, V, Brunner, N, Holst-Hansen, C, Skobe, M, Fusenig, N.E, Carmeliet, P, Collen, D, Foidart, J.M

“…Acquisition of invasive/metastatic potential through protease expression is an essential event in tumor progression. High levels of components of the…”
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Epidermal Organization and Differentiation of HaCaT Keratinocytes in Organotypic Coculture with Human Dermal Fibroblasts by Schoop, Veronika M., Fusenig, Norbert E., Mirancea, Nicolae

“…The immortal human keratinocyte line HaCaT is frequently used as a paradigm for skin keratinocytes in vitro because of its highly preserved differentiation…”
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The Plasminogen Activator Inhibitor PAI-1 Controls in Vivo Tumor Vascularization by Interaction with Proteases, Not Vitronectin: Implications for Antiangiogenic Strategies by Bajou, Khalid, Masson, Véronique, Gerard, Robert D., Schmitt, Petra M., Albert, Valérie, Praus, Michael, Lund, Leif R., Frandsen, Thomas L., Brunner, Nils, Dano, Keld, Fusenig, Norbert E., Weidle, Ulrich, Carmeliet, Geert, Loskutoff, David, Collen, Desiré, Carmeliet, Peter, Foidart, Jean Michel, Noël, Agnès

“…The plasminogen (Plg)/plasminogen activator (PA) system plays a key role in cancer progression, presumably via mediating extracellular matrix degradation and…”
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Tumorigenic Conversion of Immortal Human Keratinocytes through Stromal Cell Activation by Skobe, Mihaela, Fusenig, Norbert E.

“…The stromal microenvironment plays a crucial role in tumor development and progression. One of the most potent activators of stromal cells is the…”
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Organotypic Keratinocyte Cocultures in Defined Medium with Regular Epidermal Morphogenesis and Differentiation by Stark, Hans-Jürgen, Baur, Markus, Breitkreutz, Dirk, Mirancea, Nicolae, Fusenig, Norbert E.

“…Skin equivalents formed by keratinocytes cocultured with fibroblasts embedded in collagen lattices represent promising tools for mechanistic studies of skin…”
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Keratinocyte Growth Regulation in Defined Organotypic Cultures Through IL-1-Induced Keratinocyte Growth Factor Expression in Resting Fibroblasts by Maas-Szabowski, Nicole, Stark, Hans-Jürgen, Fusenig, Norbert E.

“…Balanced keratinocyte proliferation and differentiation resulting in regular tissue organization strictly depend on dermal support. Organotypic cultures…”
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Mutual Induction of Growth Factor Gene Expression by Epidermal-Dermal Cell Interaction by Smola, Hans, Thiekötter, Gabi, Fusenig, Norbert E.

“…Epithelial-mesenchymal interactions control epidermal growth and differentiation, but little is known about the mechanisms of this interaction. We have…”
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Normal Keratinization in a Spontaneously Immortalized Aneuploid Human Keratinocyte Cell Line by Boukamp, Petra, Petrussevska, Rule T., Breitkreutz, Dirk, Hornung, Jürgen, Markham, Alex, Fusenig, Norbert E.

“…In contrast to mouse epidermal cells, human skin keratinocytes are rather resistant to transformation in vitro. Immortalization has been achieved by SV40 but…”
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Tumorigenic conversion of immortal human skin keratinocytes (HaCaT) by elevated temperature by BOUKAMP, P, POPP, S, BLEUEL, K, TOMAKIDI, E, BÜRKLE, A, FUSENIG, N. E

“…UV-radiation is a major risk factor for non-melanoma skin cancer causing specific mutations in the p53 tumor suppressor gene and other genetic aberrations. We…”
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c-Jun and JunB Antagonistically Control Cytokine-Regulated Mesenchymal–Epidermal Interaction in Skin by Szabowski, Axel, Maas-Szabowski, Nicole, Andrecht, Sven, Kolbus, Andrea, Schorpp-Kistner, Marina, Fusenig, Norbert E, Angel, Peter

“…Interactions between mesenchymal and epithelial cells are responsible for organogenesis and tissue homeostasis. This mutual cross-talk involves cell surface…”
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Volumetric computed tomography (VCT): a new technology for noninvasive, high-resolution monitoring of tumor angiogenesis by Kiessling, Fabian, Greschus, Susanne, Lichy, Matthias P, Bock, Michael, Fink, Christian, Vosseler, Silvia, Moll, Jens, Mueller, Margareta M, Fusenig, Norbert E, Traupe, Horst, Semmler, Wolfhard

“…Volumetric computed tomography (VCT) is a technology in which area detectors are used for imaging large volumes of a subject with isotropic imaging resolution…”
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Autocrine Growth Regulation by Granulocyte Colony-Stimulating Factor and Granulocyte Macrophage Colony-Stimulating Factor in Human Gliomas with Tumor Progression by Mueller, Margareta M., Herold-Mende, Christel C., Riede, Daniela, Lange, Manfred, Steiner, Hans-Herbert, Fusenig, Norbert E.

“…Granulocyte colony-stimulating factor (G-CSF) and granulocyte macrophage colony-stimulating factor (GM-CSF) and/or their receptors are increasingly detected in…”
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Expression and functional significance of vascular endothelial growth factor receptors in human tumor cells by Herold-Mende, C, Steiner, H H, Andl, T, Riede, D, Buttler, A, Reisser, C, Fusenig, N E, Mueller, M M

“…Vascular endothelial growth factor (VEGF) is one of the key factors in tumor neoangiogenesis, acting through its receptors KDR (VEGFR-2) and fit-1 (VEGFR-1)…”
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Keratinocyte growth regulation in fibroblast cocultures via a double paracrine mechanism by Maas-Szabowski, N, Shimotoyodome, A, Fusenig, N E

“…Epithelial-mesenchymal interactions play an important role in regulating tissue homeostasis and repair. For skin, the regulatory mechanisms of epidermal-dermal…”
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Constitutive expression of G‐CSF and GM‐CSF in human skin carcinoma cells with functional consequence for tumor progression by Mueller, Margareta M., Fusenig, Norbert E.

“…Tumor progression is characterized by an increasing escape of tumor cells from the growth control of their microenvironment, often caused by aberrant…”
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Angiogenic switch occurs late in squamous cell carcinomas of human skin by STRIETH, S, HARTSCHUH, W, PILZ, L, FUSENIG, N. E

“…Angiogenesis is a crucial event in carcinogenesis and its onset has been associated with premalignant tumour stages. In order to elucidate the significance of…”
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Halting angiogenesis suppresses carcinoma cell invasion by Skobe, Mihaela, Rockwell, Patricia, Goldstein, Neil, Vosseler, Silvia, Fusenig, Norbert E

“…The importance of angiogenesis in malignant tumor growth has been interpreted mainly in terms of oxygen and nutrient supply. Here we demonstrate its…”
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Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes by Fusenig, Norbert E., Boukamp, Petra

“…An in vitro carcinogenesis model of human skin keratinocytes has been developed based on the spontaneously immortalized keratinocyte cell line HaCaT…”
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Carcinoma-like vascular density in atypic keratoacanthoma suggests malignant progression by STRIETH, S, HARTSCHUH, W, PILZ, L, FUSENIG, N. E

“…Differential diagnosis between keratoacanthomas and well differentiated squamous cell carcinomas based on clinical and histomorphological data is problematic…”
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TGF-β isoforms are differentially expressed in increasing malignant grades of HaCaT keratinocytes, suggesting separate roles in skin carcinogenesis by Gold, Leslie I., Jussila, Tommi, Fusenig, Norbert E., Stenbäck, Frej

“…The three mammalian isoforms of transforming growth factor‐β (TGF‐β1, ‐β2, and ‐β3) are potent regulators of cell growth, differentiation, and extracellular…”
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