Search Results - "FURUMAI, Ryohei"

UBE3A regulates the transcription of IRF, an antiviral immunity by Furumai, Ryohei, Tamada, Kota, Liu, Xiaoxi, Takumi, Toru

“…UBE3A is a gene responsible for the pathogenesis of Angelman syndrome (AS), a neurodevelopmental disorder characterized by symptoms such as intellectual…”
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Perturbation of Ribosome Biogenesis Drives Cells into Senescence through 5S RNP-Mediated p53 Activation by Nishimura, Kazuho, Kumazawa, Takuya, Kuroda, Takao, Katagiri, Naohiro, Tsuchiya, Mai, Goto, Natsuka, Furumai, Ryohei, Murayama, Akiko, Yanagisawa, Junn, Kimura, Keiji

“…The 5S ribonucleoprotein particle (RNP) complex, consisting of RPL11, RPL5, and 5S rRNA, is implicated in p53 regulation under ribotoxic stress. Here, we show…”
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Spliceostatin A blocks angiogenesis by inhibiting global gene expression including VEGF by Furumai, Ryohei, Uchida, Kazuyo, Komi, Yusuke, Yoneyama, Misao, Ishigami, Ken, Watanabe, Hidenori, Kojima, Soichi, Yoshida, Minoru

“…Spliceostatin A (SSA) is a methylated derivative of an antitumor natural product FR901464, which specifically binds and inhibits the SF3b spliceosome…”
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Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin by Furumai, Ryohei, Komatsu, Yasuhiko, Nishino, Norikazu, Khochbin, Saadi, Yoshida, Minoru, Horinouchi, Sueharu

“…Trichostatin A (TSA) and trapoxin (TPX) are potent inhibitors of histone deacetylases (HDACs). TSA is proposed to block the catalytic reaction by chelating a…”
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Potent Histone Deacetylase Inhibitors Built from Trichostatin A and Cyclic Tetrapeptide Antibiotics Including Trapoxin by Furumai, Ryohei, Komatsu, Yasuhiko, Nishino, Norikazu, Khochbin, Saadi, Yoshida, Minoru, Horinouchi, Sueharu

“…Trichostatin A (TSA) and trapoxin (TPX) are potent inhibitors of histone deacetylases (HDACs). TSA is proposed to block the catalytic reaction by chelating a…”
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Histone deacetylase inhibitors block nuclear factor‐κB‐dependent transcription by interfering with RNA polymerase II recruitment by Furumai, Ryohei, Ito, Akihiro, Ogawa, Kenji, Maeda, Satoko, Saito, Akiko, Nishino, Norikazu, Horinouchi, Sueharu, Yoshida, Minoru

“…Histone deacetylase inhibitors (HDACi) have been shown to exhibit anti‐inflammatory activity, but their mechanism of action is poorly understood. Trichostatin…”
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The role of class I histone deacetylase (HDAC) on gluconeogenesis in liver by Oiso, Hiroshi, Furukawa, Noboru, Suefuji, Mihoshi, Shimoda, Seiya, Ito, Akihiro, Furumai, Ryohei, Nakagawa, Junichi, Yoshida, Minoru, Nishino, Norikazu, Araki, Eiichi

“…► A novel class I HDAC inhibitor decreased hepatic PEPCK mRNA and gluconeogenesis. ► Inhibition of HDAC decreased PEPCK by reducing HNF4α expression and FoxO1…”
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Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells by Jardim, Melanie J, Wang, Qinhong, Furumai, Ryohei, Wakeman, Timothy, Goodman, Barbara K, Wang, Xiao-Fan

“…Genomic instability in colorectal cancer is categorized into two distinct classes: chromosome instability (CIN) and microsatellite instability (MSI). MSI is…”
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The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis by Kajiro, Masashi, Tsuchiya, Mai, Kawabe, Yoh-Ichi, Furumai, Ryohei, Iwasaki, Naoya, Hayashi, Yuki, Katano, Miyuki, Nakajima, Yuka, Goto, Natsuka, Watanabe, Tatsuya, Murayama, Akiko, Oishi, Hisashi, Ema, Masatsugu, Takahashi, Satoru, Kishimoto, Hiroyuki, Yanagisawa, Junn

“…Protein ubiquitination is a post-translational protein modification that regulates many biological conditions. Trip12 is a HECT-type E3 ubiquitin ligase that…”
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Stable RNA interference-mediated suppression of cyclophilin A diminishes non-small-cell lung tumor growth In vivo by HOWARD, Brandon A, FURUMAI, Ryohei, CAMPA, Michael J, RABBANI, Zahid N, VUJASKOVIC, Zeljko, WANG, Xiao-Fan, PATZ, Edward F

“…Cyclophilin A (CypA) was recently reported to be overexpressed in non-small-cell lung cancer, and represents a potentially novel therapeutic target. To…”
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Protein Phosphatase 5 Is Required for ATR-Mediated Checkpoint Activation by Zhang, Ji, Bao, Shideng, Furumai, Ryohei, Kucera, Katerina S., Ali, Ambereen, Dean, Nicolas M., Wang, Xiao-Fan

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Histone deacetylase as a new target for cancer chemotherapy by YOSHIDA, Minoru, FURUMAI, Ryohei, NISHIYAMA, Akoto, KOMATSU, Yasuhiko, NISHINO, Norikazu, HORINOUCHI, Sueharu

“…Trichostatin A (TSA) and trapoxin (TPX), inhibitors of the eukaryotic cell cycle and inducers of morphological reversion of transformed cells, inhibit histone…”
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Neuronal Differentiation of Neuro 2a Cells by Inhibitors of Cell Cycle Progression, Trichostatin A and Butyrolactone I by Inokoshi, Junji, Katagiri, Masako, Arima, Shiho, Tanaka, Haruo, Hayashi, Masahiko, Bae Kim, Young, Furumai, Ryohei, Yoshida, Minoru, Horinouchi, Sueharu, Ōmura, Satoshi

“…Trichostatin A (TSA, 17 nM), a specific and reversible inhibitor of histone deacetylase induced neurite network formation at and after 4 days. The networks…”
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FK228 (depsipeptide) as a natural prodrug that inhibits class I histone deacetylases by FURUMAI, Ryohei, MATSUYAMA, Akihisa, HORINOUCHI, Sueharu, KOBASHI, Nobuyuki, LEE, Kun-Hyung, NISHIYAMA, Makoto, NAKAJIMA, Hidenori, TANAKA, Akito, KOMATSU, Yasuhiko, NISHINO, Norikazu, YOSHIDA, Minoru

“…FK228 is a histone deacetylase (HDAC) inhibitor, the molecular mechanism of inhibition of which has been unknown. Here we show that reduction of an…”
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Histone deacetylase inhibitors block nuclear factoraIoBadependent transcription by interfering with RNA polymerase II recruitment by Furumai, Ryohei, Ito, Akihiro, Ogawa, Kenji, Maeda, Satoko, Saito, Akiko, Nishino, Norikazu, Horinouchi, Sueharu, Yoshida, Minoru

“…Histone deacetylase inhibitors (HDACi) have been shown to exhibit anti-inflammatory activity, but their mechanism of action is poorly understood. Trichostatin…”
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Cyclic hydroxamic-acid-containing peptide 31, a potent synthetic histone deacetylase inhibitor with antitumor activity by KOMATSU, Yasuhiko, TOMIZAKI, Kin-Ya, HORINOUCHI, Sueharu, HAYASHI, Hideya, TSUKAMOTO, Makiko, KATO, Tamaki, NISHINO, Norikazu, SATO, Shigeo, YAMORI, Takao, TSURUO, Takashi, FURUMAI, Ryohei, YOSHIDA, Minoru

“…Cyclic hydroxamic-acid-containing peptide 1 (CHAP1), designed as a hybrid of trichostatin A and trapoxin, is a lead compound for the development of potent…”
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ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background by Fang, Yanan, Tsao, Cheng-Chung, Goodman, Barbara K, Furumai, Ryohei, Tirado, Carlos A, Abraham, Robert T, Wang, Xiao-Fan

“…The ataxia‐telangiectasia mutated and rad3‐related (ATR) kinase orchestrates cellular responses to DNA damage and replication stress. Complete loss of ATR…”
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