Search Results - "FURUKAWA, Takako"

An RNA-binding protein, Qki5, regulates embryonic neural stem cells through pre-mRNA processing in cell adhesion signaling by Hayakawa-Yano, Yoshika, Suyama, Satoshi, Nogami, Masahiro, Yugami, Masato, Koya, Ikuko, Furukawa, Takako, Zhou, Li, Abe, Manabu, Sakimura, Kenji, Takebayashi, Hirohide, Nakanishi, Atsushi, Okano, Hideyuki, Yano, Masato

“…Cell type-specific transcriptomes are enabled by the action of multiple regulators, which are frequently expressed within restricted tissue regions. In the…”
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Cytosolic acetyl‐CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl‐CoA/acetate metabolism by Yoshii, Yukie, Furukawa, Takako, Yoshii, Hiroshi, Mori, Tetsuya, Kiyono, Yasushi, Waki, Atsuo, Kobayashi, Masato, Tsujikawa, Tetsuya, Kudo, Takashi, Okazawa, Hidehiko, Yonekura, Yoshiharu, Fujibayashi, Yasuhisa

“…Understanding tumor‐specific metabolism under hypoxia is important to find novel targets for antitumor drug design. Here we found that tumor cells expressed…”
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Prediction of hepatic and intestinal glucuronidation using in vitro–in vivo extrapolation by Naritomi, Yoichi, Nakamori, Fumihiro, Furukawa, Takako, Tabata, Kenji

“…The accurate prediction of hepatic (Fh) and intestinal availability (Fg) is vital for determining human pharmacokinetics. To predict these PK parameters for…”
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The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation by Yoshii, Yukie, Waki, Atsuo, Yoshida, Kaori, Kakezuka, Anna, Kobayashi, Maki, Namiki, Hideo, Kuroda, Yusei, Kiyono, Yasushi, Yoshii, Hiroshi, Furukawa, Takako, Asai, Tatsuya, Okazawa, Hidehiko, Gelovani, Juri G, Fujibayashi, Yasuhisa

“…Abstract Two-dimensional (2D) cell cultures are essential for drug development and tumor research. However, the limitations of 2D cultures are widely…”
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In-vivo imaging of a mouse by detecting bremsstrahlung X-rays from 14C using a La-GPS imaging system by Yamamoto, Seiichi, Tomita, Hideki, Terabayashi, Ryohei, Yoshida, Kenji, Nakanishi, Kouhei, Furukawa, Takako, Kamada, Kei, Yoshikawa, Akira

“…Imaging of 14 C outside of the subject is considered to be difficult because it is a radionuclide that emits only low-energy beta particles. However, we found…”
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DNA damage stress-induced translocation of mutant FUS proteins into cytosolic granules and screening for translocation inhibitors by Nogami, Masahiro, Sano, Osamu, Adachi-Tominari, Keiko, Hayakawa-Yano, Yoshika, Furukawa, Takako, Iwata, Hidehisa, Ogi, Kazuhiro, Okano, Hideyuki, Yano, Masato

“…Fused in sarcoma/translated in liposarcoma (FUS) is an RNA-binding protein, and its mutations are associated with neurodegenerative diseases, including…”
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Effect of Gold Nanoparticle Radiosensitization on Plasmid DNA Damage Induced by High-Dose-Rate Brachytherapy by Yogo, Katsunori, Misawa, Masaki, Shimizu, Morihito, Shimizu, Hidetoshi, Kitagawa, Tomoki, Hirayama, Ryoichi, Ishiyama, Hiromichi, Furukawa, Takako, Yasuda, Hiroshi

“…Gold nanoparticles (AuNPs) are candidate radiosensitizers for medium-energy photon treatment, such as γ-ray radiation in high-dose-rate (HDR) brachytherapy…”
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Fatty acid synthase is a key target in multiple essential tumor functions of prostate cancer: uptake of radiolabeled acetate as a predictor of the targeted therapy outcome by Yoshii, Yukie, Furukawa, Takako, Oyama, Nobuyuki, Hasegawa, Yoko, Kiyono, Yasushi, Nishii, Ryuichi, Waki, Atsuo, Tsuji, Atsushi B, Sogawa, Chizuru, Wakizaka, Hidekatsu, Fukumura, Toshimitsu, Yoshii, Hiroshi, Fujibayashi, Yasuhisa, Lewis, Jason S, Saga, Tsuneo

“…Fatty acid synthase (FASN) expression is elevated in several cancers, and this over-expression is associated with poor prognosis. Inhibitors of FASN, such as…”
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Copper-64-Labeled Antibody Fragments for Immuno-PET/Radioimmunotherapy with Low Renal Radioactivity Levels and Amplified Tumor-Kidney Ratios by Suzuki, Hiroyuki, Kise, Shota, Kaizuka, Yuta, Watanabe, Reo, Sugawa, Tsubasa, Furukawa, Takako, Fujii, Hirofumi, Uehara, Tomoya

“…Copper-64 (64Cu)-labeled antibody fragments such as Fab are useful for molecular imaging (immuno-PET) and radioimmunotherapy. However, these fragments cause…”
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Molecular Imaging of Aquaglycero-Aquaporins: Its Potential for Cancer Characterization by Saito, Yuriko, Furukawa, Takako, Obata, Takayuki, Saga, Tsuneo

“…Aquaglycero-aquaporins (agAQPs) are one of the water channel proteins located in the cell membrane that transport not only water but also some small solutes…”
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Antiemetic Effect of a Potent and Selective Neurokinin-1 Receptor Antagonist, FK886, on Cisplatin-Induced Acute and Delayed Emesis in Ferrets by Furukawa, Takako Yoshino, Nakayama, Hiroe, Imazumi, Katsunori, Yamakuni, Hisashi, Takeshita, Koji, Matsuo, Masahiko, Manda, Toshitaka, Uchida, Wataru

“…The antiemetic effect of a potent and selective neurokinin-1 (NK1) receptor antagonist, FK886…”
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Sbp2l contributes to oligodendrocyte maturation through translational control in Tcf7l2 signaling by Yugami, Masato, Hayakawa-Yano, Yoshika, Ogasawara, Takahisa, Yokoyama, Kazumasa, Furukawa, Takako, Hara, Hiroe, Hashikami, Kentaro, Tsuji, Isamu, Takebayashi, Hirohide, Araki, Shinsuke, Okano, Hideyuki, Yano, Masato

“…Oligodendrocytes (OLs) are the myelin-forming cells in the CNS that support neurons through the insulating sheath of axons. This unique feature and…”
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Efficient construction of homozygous diploid strains identifies genes required for the hyper-filamentous phenotype in Saccharomyces cerevisiae by Furukawa, Kentaro, Furukawa, Takako, Hohmann, Stefan

“…Yeast cells undergo diploid-specific developments such as spore formation via meiosis and pseudohyphal development under certain nutrient-limited conditions…”
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Positron emission tomography of cerebral angiogenesis and TSPO expression in a mouse model of chronic hypoxia by Kanno, Iwao, Seki, Chie, Takuwa, Hiroyuki, Jin, Zhao-Hui, Boturyn, Didier, Dumy, Pascal, Furukawa, Takako, Saga, Tsuneo, Ito, Hiroshi, Masamoto, Kazuto

“…The present study aimed to examine whether positron emission tomography (PET) could evaluate cerebral angiogenesis. Mice were housed in a hypoxic chamber with…”
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Antiemetic Effects of a Potent and Selective Neurokinin-1 Receptor Antagonist, FK886, on Cisplatin- and Apomorphine-Induced Emesis in Dogs by Furukawa, Takako Yoshino, Nakayama, Hiroe, Kikuchi, Aya, Imazumi, Katsunori, Yamakuni, Hisashi, Sogabe, Hajime, Yamasaki, Sachiko, Takeshita, Koji, Matsuo, Masahiko, Manda, Toshitaka, Uchida, Wataru

“…The antiemetic properties of a novel neurokinin-1 (NK1) receptor antagonist, FK886…”
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Immunotargeting of Integrin α6β4 for Single-Photon Emission Computed Tomography and Near-Infrared Fluorescence Imaging in a Pancreatic Cancer Model by Aung, Winn, Tsuji, Atsushi B., Sudo, Hitomi, Sugyo, Aya, Furukawa, Takako, Ukai, Yoshinori, Kurosawa, Yoshikazu, Saga, Tsuneo

“…To explore suitable imaging probes for early and specific detection of pancreatic cancer, we demonstrated that α6β4 integrin is a good target and employed…”
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Development of the Fibronectin–Mimetic Peptide KSSPHSRN(SG)5RGDSP as a Novel Radioprobe for Molecular Imaging of the Cancer Biomarker α5β1 Integrin by Jin, Zhao-Hui, Furukawa, Takako, Kumata, Katsushi, Xie, Lin, Yui, Joji, Wakizaka, Hidekatsu, Fujibayashi, Yasuhisa, Zhang, Ming-Rong, Saga, Tsuneo

“…α5β1 Integrin, a fibronectin receptor, is becoming a pertinent therapeutic target and a promising prognostic biomarker for cancer patients. The aim of this…”
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Effect of Multimerization of a Linear Arg-Gly-Asp Peptide on Integrin Binding Affinity and Specificity by Jin, Zhao-Hui, Furukawa, Takako, Waki, Atsuo, Akaji, Kenichi, Coll, Jean-Luc, Saga, Tsuneo, Fujibayashi, Yasuhisa

“…Multivalent interactions are frequently used to enhance ligand-receptor binding affinity. In this study, mono-, di- and trimeric…”
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Molecular imaging of cancer—evaluating characters of individual cancer by PET/SPECT imaging by Saga, Tsuneo, Koizumi, Mitsuru, Furukawa, Takako, Yoshikawa, Kyosan, Fujibayashi, Yasuhisa

“…The present status of cancer molecular imaging (MI) with nuclear medicine techniques is reviewed, highlighting the Japanese activities in this field. With the…”
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Quantitative Prediction of Intestinal Glucuronidation of Drugs in Rats Using In Vitro Metabolic Clearance Data by Furukawa, Takako, Nakamori, Fumihiro, Tetsuka, Kazuhiro, Naritomi, Yoichi, Moriguchi, Hiroyuki, Yamano, Katsuhiro, Terashita, Shigeyuki, Teramura, Toshio

“…UDP-glucuronosyltransferase (UGT) is highly expressed in the small intestine and catalyzes the glucuronidation of small molecules, which may affect the oral…”
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